CN116075513A - Nek7激酶的抑制剂 - Google Patents

Nek7激酶的抑制剂 Download PDF

Info

Publication number
CN116075513A
CN116075513A CN202180057370.7A CN202180057370A CN116075513A CN 116075513 A CN116075513 A CN 116075513A CN 202180057370 A CN202180057370 A CN 202180057370A CN 116075513 A CN116075513 A CN 116075513A
Authority
CN
China
Prior art keywords
compound
amine
pyrazolo
mmol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180057370.7A
Other languages
English (en)
Chinese (zh)
Inventor
大卫·詹姆斯·比尔斯
约翰·世强·考韦三世
亚历克西斯·亨利·阿贝尔·莫拉德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Halia Therapeutics Inc
Original Assignee
Halia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Halia Therapeutics Inc filed Critical Halia Therapeutics Inc
Publication of CN116075513A publication Critical patent/CN116075513A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
CN202180057370.7A 2020-06-08 2021-06-08 Nek7激酶的抑制剂 Pending CN116075513A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063036244P 2020-06-08 2020-06-08
US63/036,244 2020-06-08
US202163170776P 2021-04-05 2021-04-05
US63/170,776 2021-04-05
US202163185257P 2021-05-06 2021-05-06
US63/185,257 2021-05-06
PCT/US2021/036398 WO2021252488A1 (en) 2020-06-08 2021-06-08 Inhibitors of nek7 kinase

Publications (1)

Publication Number Publication Date
CN116075513A true CN116075513A (zh) 2023-05-05

Family

ID=76731040

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180057370.7A Pending CN116075513A (zh) 2020-06-08 2021-06-08 Nek7激酶的抑制剂

Country Status (13)

Country Link
US (1) US20230203045A1 (https=)
EP (1) EP4161933A1 (https=)
JP (1) JP2023528659A (https=)
KR (1) KR20230035311A (https=)
CN (1) CN116075513A (https=)
AU (1) AU2021289345A1 (https=)
BR (1) BR112022025012A2 (https=)
CA (1) CA3186041A1 (https=)
CO (1) CO2022019131A2 (https=)
IL (1) IL298849A (https=)
MX (1) MX2022015495A (https=)
TW (1) TWI908811B (https=)
WO (1) WO2021252488A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025140570A1 (zh) * 2023-12-29 2025-07-03 北京普祺医药科技股份有限公司 一种nek7抑制剂、药物组合物及其用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65962B1 (sr) 2020-05-08 2024-10-31 Halia Therapeutics Inc Inhibitori nek7 kinaze
US20240400551A1 (en) * 2021-01-25 2024-12-05 Halia Therapeutics, Inc. Nek7 inhibitors
US20240158394A1 (en) * 2022-09-14 2024-05-16 Halia Therapeutics, Inc. Nek7 inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019192962A1 (en) * 2018-04-05 2019-10-10 Merck Patent Gmbh Heteroaryl compounds as type ii irak inhibitors and uses hereof
WO2020035465A1 (en) * 2017-08-15 2020-02-20 Inflazome Limited Novel sulfoneurea compounds
CN111646995A (zh) * 2019-03-04 2020-09-11 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
CN112552302A (zh) * 2019-09-26 2021-03-26 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
US20110189167A1 (en) 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
EP2802212B1 (en) 2012-01-12 2015-12-30 Basf Se Herbicidal isoxazolo[5,4-b]pyridines
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
RU2724345C2 (ru) 2015-10-09 2020-06-23 Галапагос Нв N-СУЛЬФОНИЛИРОВАННЫЕ ПИРАЗОЛО[3,4-b]ПИРИДИН-6-КАРБОКСАМИДЫ И СПОСОБ ИХ ПРИМЕНЕНИЯ
CN108250200A (zh) 2016-12-28 2018-07-06 中国科学院上海药物研究所 一种具有Axl抑制活性的化合物及其制备和应用
DE102017200543A1 (de) 2017-01-13 2018-07-19 Baden-Württemberg Stiftung Ggmbh Verfahren zur Behandlung einer Oberfläche eines Hartmetallkörpers und zur Beschichtung des behandelten Hartmetallkörpers mit einer Diamantschicht
DE102017118230B4 (de) * 2017-08-10 2021-04-22 Christoph Lucks Verfahren zur Analyse und/oder Überwachung von Brücken sowie entsprechendes System und entsprechende Verwendung
KR20200087759A (ko) 2017-11-09 2020-07-21 인플라좀 리미티드 신규한 설폰아마이드 카복스아마이드 화합물
AR118119A1 (es) 2019-02-18 2021-09-22 Genentech Inc Compuestos de pirido-pirimidinilo y métodos de uso
AU2020436612A1 (en) * 2020-03-16 2022-09-01 Flash Therapeutics, Llc Compounds for treating or inhibiting recurrence of acute myeloid leukemia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020035465A1 (en) * 2017-08-15 2020-02-20 Inflazome Limited Novel sulfoneurea compounds
WO2019192962A1 (en) * 2018-04-05 2019-10-10 Merck Patent Gmbh Heteroaryl compounds as type ii irak inhibitors and uses hereof
CN111646995A (zh) * 2019-03-04 2020-09-11 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
CN112552302A (zh) * 2019-09-26 2021-03-26 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025140570A1 (zh) * 2023-12-29 2025-07-03 北京普祺医药科技股份有限公司 一种nek7抑制剂、药物组合物及其用途

Also Published As

Publication number Publication date
BR112022025012A2 (pt) 2023-02-14
US20230203045A1 (en) 2023-06-29
IL298849A (en) 2023-02-01
CO2022019131A2 (es) 2023-03-07
KR20230035311A (ko) 2023-03-13
WO2021252488A1 (en) 2021-12-16
CA3186041A1 (en) 2021-12-16
JP2023528659A (ja) 2023-07-05
TW202208368A (zh) 2022-03-01
EP4161933A1 (en) 2023-04-12
AU2021289345A1 (en) 2023-01-19
MX2022015495A (es) 2023-03-14
TWI908811B (zh) 2025-12-21

Similar Documents

Publication Publication Date Title
CN115843272B (zh) Nek7激酶的抑制剂
CN116075513A (zh) Nek7激酶的抑制剂
WO2022216680A1 (en) Nek7 inhibitors
CN119585256A (zh) 趋化因子受体调节剂及其用途
WO2022159835A1 (en) Nek7 inhibitors
WO2024059200A1 (en) Nek7 inhibitors
CN117597346A (zh) Nek7抑制剂
RU2848120C1 (ru) Ингибиторы киназы nek7
US20250177382A1 (en) Nek7 inhibitors
RU2848134C1 (ru) Ингибиторы киназы nek7
RU2860767C2 (ru) Ингибиторы nek7
HK40088615B (en) Inhibitors of nek7 kinase
HK40088615A (en) Inhibitors of nek7 kinase

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination