TWI908811B - Nek7激酶抑制劑 - Google Patents

Nek7激酶抑制劑

Info

Publication number
TWI908811B
TWI908811B TW110120796A TW110120796A TWI908811B TW I908811 B TWI908811 B TW I908811B TW 110120796 A TW110120796 A TW 110120796A TW 110120796 A TW110120796 A TW 110120796A TW I908811 B TWI908811 B TW I908811B
Authority
TW
Taiwan
Prior art keywords
amino
pyrazolo
halogen
mmol
compound
Prior art date
Application number
TW110120796A
Other languages
English (en)
Chinese (zh)
Other versions
TW202208368A (zh
Inventor
大衛 詹姆士 比爾斯
約翰 賽 姜 三世 考維
亞歷克西斯 亨利 亞貝 莫拉德
Original Assignee
美商哈利亞製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商哈利亞製藥公司 filed Critical 美商哈利亞製藥公司
Publication of TW202208368A publication Critical patent/TW202208368A/zh
Application granted granted Critical
Publication of TWI908811B publication Critical patent/TWI908811B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
TW110120796A 2020-06-08 2021-06-08 Nek7激酶抑制劑 TWI908811B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063036244P 2020-06-08 2020-06-08
US63/036,244 2020-06-08
US202163170776P 2021-04-05 2021-04-05
US63/170,776 2021-04-05
US202163185257P 2021-05-06 2021-05-06
US63/185,257 2021-05-06

Publications (2)

Publication Number Publication Date
TW202208368A TW202208368A (zh) 2022-03-01
TWI908811B true TWI908811B (zh) 2025-12-21

Family

ID=76731040

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110120796A TWI908811B (zh) 2020-06-08 2021-06-08 Nek7激酶抑制劑

Country Status (13)

Country Link
US (1) US20230203045A1 (https=)
EP (1) EP4161933A1 (https=)
JP (1) JP2023528659A (https=)
KR (1) KR20230035311A (https=)
CN (1) CN116075513A (https=)
AU (1) AU2021289345A1 (https=)
BR (1) BR112022025012A2 (https=)
CA (1) CA3186041A1 (https=)
CO (1) CO2022019131A2 (https=)
IL (1) IL298849A (https=)
MX (1) MX2022015495A (https=)
TW (1) TWI908811B (https=)
WO (1) WO2021252488A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65962B1 (sr) 2020-05-08 2024-10-31 Halia Therapeutics Inc Inhibitori nek7 kinaze
US20240400551A1 (en) * 2021-01-25 2024-12-05 Halia Therapeutics, Inc. Nek7 inhibitors
US20240158394A1 (en) * 2022-09-14 2024-05-16 Halia Therapeutics, Inc. Nek7 inhibitors
WO2025140570A1 (zh) * 2023-12-29 2025-07-03 北京普祺医药科技股份有限公司 一种nek7抑制剂、药物组合物及其用途

Citations (1)

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WO2019192962A1 (en) * 2018-04-05 2019-10-10 Merck Patent Gmbh Heteroaryl compounds as type ii irak inhibitors and uses hereof

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US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
US20110189167A1 (en) 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
EP2802212B1 (en) 2012-01-12 2015-12-30 Basf Se Herbicidal isoxazolo[5,4-b]pyridines
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
RU2724345C2 (ru) 2015-10-09 2020-06-23 Галапагос Нв N-СУЛЬФОНИЛИРОВАННЫЕ ПИРАЗОЛО[3,4-b]ПИРИДИН-6-КАРБОКСАМИДЫ И СПОСОБ ИХ ПРИМЕНЕНИЯ
CN108250200A (zh) 2016-12-28 2018-07-06 中国科学院上海药物研究所 一种具有Axl抑制活性的化合物及其制备和应用
DE102017200543A1 (de) 2017-01-13 2018-07-19 Baden-Württemberg Stiftung Ggmbh Verfahren zur Behandlung einer Oberfläche eines Hartmetallkörpers und zur Beschichtung des behandelten Hartmetallkörpers mit einer Diamantschicht
DE102017118230B4 (de) * 2017-08-10 2021-04-22 Christoph Lucks Verfahren zur Analyse und/oder Überwachung von Brücken sowie entsprechendes System und entsprechende Verwendung
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AR118119A1 (es) 2019-02-18 2021-09-22 Genentech Inc Compuestos de pirido-pirimidinilo y métodos de uso
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WO2021057877A1 (zh) * 2019-09-26 2021-04-01 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途
AU2020436612A1 (en) * 2020-03-16 2022-09-01 Flash Therapeutics, Llc Compounds for treating or inhibiting recurrence of acute myeloid leukemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019192962A1 (en) * 2018-04-05 2019-10-10 Merck Patent Gmbh Heteroaryl compounds as type ii irak inhibitors and uses hereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
期刊 XUE YUAN ET AL. "Identification of Pyrrolo[2,3-d] pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia" , JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. *
期刊 XUE YUAN ET AL. "Identification of Pyrrolo[2,3-d] pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia" , JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. 8, April 2, 2019, pages 4158-4173.

Also Published As

Publication number Publication date
BR112022025012A2 (pt) 2023-02-14
CN116075513A (zh) 2023-05-05
US20230203045A1 (en) 2023-06-29
IL298849A (en) 2023-02-01
CO2022019131A2 (es) 2023-03-07
KR20230035311A (ko) 2023-03-13
WO2021252488A1 (en) 2021-12-16
CA3186041A1 (en) 2021-12-16
JP2023528659A (ja) 2023-07-05
TW202208368A (zh) 2022-03-01
EP4161933A1 (en) 2023-04-12
AU2021289345A1 (en) 2023-01-19
MX2022015495A (es) 2023-03-14

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