|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US6534055B1
(en)
|
1988-11-23 |
2003-03-18 |
Genetics Institute, Inc. |
Methods for selectively stimulating proliferation of T cells
|
|
US6905680B2
(en)
|
1988-11-23 |
2005-06-14 |
Genetics Institute, Inc. |
Methods of treating HIV infected subjects
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5582996A
(en)
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
DE69309472T2
(de)
|
1992-01-23 |
1997-10-23 |
Merck Patent Gmbh, 64293 Darmstadt |
Fusionsproteine von monomeren und dimeren von antikörperfragmenten
|
|
US7175843B2
(en)
|
1994-06-03 |
2007-02-13 |
Genetics Institute, Llc |
Methods for selectively stimulating proliferation of T cells
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US7067318B2
(en)
|
1995-06-07 |
2006-06-27 |
The Regents Of The University Of Michigan |
Methods for transfecting T cells
|
|
GB9625640D0
(en)
|
1996-12-10 |
1997-01-29 |
Celltech Therapeutics Ltd |
Biological products
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
GB9720054D0
(en)
|
1997-09-19 |
1997-11-19 |
Celltech Therapeutics Ltd |
Biological products
|
|
GB9824437D0
(en)
|
1998-11-06 |
1999-01-06 |
Ylo Herttuala Seppo |
Gene therapy
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
EP1900753B1
(en)
|
2002-11-08 |
2017-08-09 |
Ablynx N.V. |
Method of administering therapeutic polypeptides, and polypeptides therefor
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
GB0315450D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
GB0315457D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
ES2551439T5
(es)
|
2003-07-01 |
2018-11-08 |
Ucb Biopharma Sprl |
Fragmentos Fab de anticuerpos modificados
|
|
WO2005049094A1
(en)
|
2003-11-13 |
2005-06-02 |
Advantagene, Inc. |
A mixed complementary viral vector for gene therapy
|
|
WO2006028936A2
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
AU2006232287B2
(en)
|
2005-03-31 |
2011-10-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing polypeptides by regulating polypeptide association
|
|
WO2007061657A2
(en)
|
2005-11-14 |
2007-05-31 |
The Brigham & Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
EP1991577A2
(en)
*
|
2006-01-31 |
2008-11-19 |
Parkinson, John F. |
Modulation of mdl-1 activity for treatment of inflammatory disease
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
WO2008025032A1
(en)
*
|
2006-08-25 |
2008-02-28 |
Zymogenetics, Inc. |
Soluble il-27 receptor
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法
|
|
MY192182A
(en)
|
2009-06-26 |
2022-08-04 |
Regeneron Pharma |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
WO2012045334A1
(en)
*
|
2010-10-05 |
2012-04-12 |
Synthon Bv |
Biologically active il-10 fusion proteins
|
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
|
PE20150645A1
(es)
*
|
2012-08-08 |
2015-05-11 |
Roche Glycart Ag |
Proteinas de fusion de interleuquina 10 y usos de las mismas
|
|
CN105026430B
(zh)
|
2012-11-28 |
2025-03-25 |
酵活英属哥伦比亚有限公司 |
工程化免疫球蛋白重链-轻链对及其用途
|
|
TWI635098B
(zh)
|
2013-02-01 |
2018-09-11 |
再生元醫藥公司 |
含嵌合恆定區之抗體
|
|
ES2821753T3
(es)
|
2013-03-15 |
2021-04-27 |
Lilly Co Eli |
Procedimientos de producción de Fab y de anticuerpos biespecíficos
|
|
MX2015014438A
(es)
|
2013-04-18 |
2016-05-18 |
Armo Biosciences Inc |
Metodos de uso de interleucina-10 para tratar enfermedades y trastornos.
|
|
CN120242030A
(zh)
|
2013-11-11 |
2025-07-04 |
阿尔莫生物科技股份有限公司 |
将白细胞介素-10用于治疗疾病和病症的方法
|
|
WO2015117930A1
(en)
|
2014-02-06 |
2015-08-13 |
F. Hoffmann-La Roche Ag |
Interleukine 10 immunoconjugates
|
|
AU2015336101A1
(en)
|
2014-10-22 |
2017-04-20 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
CN104403004B
(zh)
|
2014-11-24 |
2017-10-13 |
苏州丁孚靶点生物技术有限公司 |
抗体‑干扰素异二聚体的制备和用途
|
|
AU2015364396B2
(en)
|
2014-12-19 |
2018-08-09 |
Alkermes, Inc. |
Single chain Fc fusion proteins
|
|
WO2016161010A2
(en)
|
2015-03-30 |
2016-10-06 |
Regeneron Pharmaceuticals, Inc. |
Heavy chain constant regions with reduced binding to fc gamma receptors
|
|
US20160361415A1
(en)
|
2015-05-28 |
2016-12-15 |
Armo Biosciences, Inc. |
Methods of Using Interleukin-10 for Treating Diseases and Disorders
|
|
WO2017087784A1
(en)
|
2015-11-18 |
2017-05-26 |
Duke University |
Tumor infiltrating lymphocytes for treatment of cancer
|
|
AU2017257254B2
(en)
*
|
2016-04-27 |
2022-02-24 |
Immunomedics, Inc. |
Efficacy of anti-Trop-2-SN-38 antibody drug conjugates for therapy of tumors relapsed/refractory to checkpoint inhibitors
|
|
WO2017210684A1
(en)
|
2016-06-03 |
2017-12-07 |
New York University |
Methods and reagents for modulating macrophage phenotype
|
|
WO2018005226A2
(en)
|
2016-06-22 |
2018-01-04 |
Alkermes, Inc. |
Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
|
|
WO2018144784A1
(en)
|
2017-02-01 |
2018-08-09 |
Smet Pharmaceutical Inc. |
MONOMERIC HUMAN IgG1 Fc AND BISPECIFIC ANTIBODIES
|
|
IL272635B2
(en)
*
|
2017-09-06 |
2024-02-01 |
Univ Yale |
Variants of interleukin-18 and methods of use
|
|
US20200353050A1
(en)
*
|
2017-11-10 |
2020-11-12 |
Armo Biosciences, Inc. |
Compositions and methods of use of interleukin-10 in combination with immune check-point pathway inhibitors
|
|
US12109249B2
(en)
*
|
2018-01-30 |
2024-10-08 |
University Of Louisville Research Foundation |
Compositions and methods for treating inflammation and cancer
|
|
WO2019242505A1
(zh)
*
|
2018-06-17 |
2019-12-26 |
上海健信生物医药科技有限公司 |
靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用
|
|
WO2020097946A1
(zh)
|
2018-11-18 |
2020-05-22 |
杭州博虎生物科技有限公司 |
一种重组人白细胞介素10融合蛋白及其应用
|
|
EP3927728A2
(en)
*
|
2019-02-21 |
2021-12-29 |
Xencor, Inc. |
Untargeted and targeted il-10 fc-fusion proteins
|
|
US20220227827A1
(en)
*
|
2019-03-25 |
2022-07-21 |
Dingfu Biotarget Co., Ltd. |
Proteinaceous heterodimer and use thereof
|
|
WO2020212598A1
(en)
*
|
2019-04-19 |
2020-10-22 |
Synerkine Pharma B.V. |
A fusion protein comprising il13
|
|
EP3795583A1
(en)
*
|
2019-09-19 |
2021-03-24 |
Ecole Polytechnique Federale de Lausanne (EPFL) |
Il10/fc fusion proteins useful as enhancers of immunotherapies
|
|
JP2023514152A
(ja)
*
|
2020-02-06 |
2023-04-05 |
ブリストル－マイヤーズ スクイブ カンパニー |
Ｉｌ－１０およびその使用
|