JP2023523174A5 - - Google Patents
Info
- Publication number
- JP2023523174A5 JP2023523174A5 JP2022562072A JP2022562072A JP2023523174A5 JP 2023523174 A5 JP2023523174 A5 JP 2023523174A5 JP 2022562072 A JP2022562072 A JP 2022562072A JP 2022562072 A JP2022562072 A JP 2022562072A JP 2023523174 A5 JP2023523174 A5 JP 2023523174A5
- Authority
- JP
- Japan
- Prior art keywords
- cxcl13
- rodent
- gene
- humanized
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063013148P | 2020-04-21 | 2020-04-21 | |
| US63/013,148 | 2020-04-21 | ||
| PCT/US2021/028087 WO2021216505A1 (en) | 2020-04-21 | 2021-04-20 | Non-human animals having a humanized cxcl13 gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023523174A JP2023523174A (ja) | 2023-06-02 |
| JP2023523174A5 true JP2023523174A5 (https=) | 2024-05-01 |
| JP7765403B2 JP7765403B2 (ja) | 2025-11-06 |
Family
ID=75850690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562072A Active JP7765403B2 (ja) | 2020-04-21 | 2021-04-20 | ヒト化ｃｘｃｌ１３遺伝子を有する非ヒト動物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230172170A1 (https=) |
| EP (1) | EP4138550A1 (https=) |
| JP (1) | JP7765403B2 (https=) |
| KR (1) | KR20230004472A (https=) |
| CN (1) | CN116075221A (https=) |
| AU (1) | AU2021261267A1 (https=) |
| CA (1) | CA3167557A1 (https=) |
| IL (1) | IL297315A (https=) |
| WO (1) | WO2021216505A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230417899A1 (en) * | 2022-06-27 | 2023-12-28 | Oshkosh Corporation | Position tracking for a lift device |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN100359004C (zh) * | 2003-12-19 | 2008-01-02 | 龚小迪 | 转基因表达细胞趋化因子的自然杀伤细胞 |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| EP4502152A3 (en) * | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| EP2899545B1 (en) * | 2010-06-23 | 2018-08-22 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| MX384291B (es) | 2013-02-20 | 2025-03-14 | Regeneron Pharma | Modificación genética de ratas. |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| RU2671101C1 (ru) | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| ES2950399T3 (es) * | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| WO2017087780A1 (en) * | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| KR102483193B1 (ko) * | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| JP2020514386A (ja) * | 2017-03-22 | 2020-05-21 | サノフイＳａｎｏｆｉ | ヒト化抗ｃｘｃｒ５抗体を使用するループスの処置 |
| WO2018234577A1 (en) * | 2017-06-23 | 2018-12-27 | Protagen Ag | IMMUNO-ONCOLOGY FOR THE TREATMENT OF CANCER |
-
2021
- 2021-04-20 JP JP2022562072A patent/JP7765403B2/ja active Active
- 2021-04-20 IL IL297315A patent/IL297315A/en unknown
- 2021-04-20 EP EP21724123.1A patent/EP4138550A1/en active Pending
- 2021-04-20 WO PCT/US2021/028087 patent/WO2021216505A1/en not_active Ceased
- 2021-04-20 KR KR1020227035003A patent/KR20230004472A/ko active Pending
- 2021-04-20 AU AU2021261267A patent/AU2021261267A1/en active Pending
- 2021-04-20 CA CA3167557A patent/CA3167557A1/en active Pending
- 2021-04-20 CN CN202180028293.2A patent/CN116075221A/zh active Pending
- 2021-04-20 US US17/920,069 patent/US20230172170A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7833059B2 (ja) | ヒトｅｐｏを発現する遺伝子改変された非ヒト動物 | |
| US11234420B2 (en) | Method for constructing PD-1 gene modified humanized animal model and use thereof | |
| KR102617691B1 (ko) | 인간화 분화 클러스터 47 유전자를 가진 비인간 동물 | |
| CN107529739B (zh) | 表达人特定分子和人Fcγ受体家族的转基因非人动物 | |
| US20200359610A1 (en) | Humanized transgenic animal | |
| CN106282122A (zh) | 一种非人哺乳动物恐惧症或其相关疾病动物模型的建立方法及其用途 | |
| JP2007536931A (ja) | 新規の遺伝子破壊、組成物およびそれらに関連する方法 | |
| CN113122574A (zh) | 一种免疫缺陷型人源化非人动物的构建方法 | |
| JP3562528B2 (ja) | Ｉｋａｒｏｓ：ｔ細胞経路調節遺伝子 | |
| JP2023523174A5 (https=) | ||
| JP2006516388A (ja) | ループス腎炎の治療用組成物および方法 | |
| JPWO2003042387A1 (ja) | 新規毛髪ケラチン付随タンパク質 | |
| ZA200606461B (en) | Gene disruptions, compositions and methods relating thereto | |
| JP2025521580A (ja) | ヒト化ｃｌｅｃ９ａ遺伝子を有する非ヒト動物 | |
| JP7765403B2 (ja) | ヒト化ｃｘｃｌ１３遺伝子を有する非ヒト動物 | |
| JP2024500153A5 (https=) | ||
| JP2005500835A (ja) | Ｐｅｒｖスクリーニング法およびその使用 | |
| CN107753957A (zh) | 一种非人哺乳动物中风或其相关疾病动物模型的建立方法及其用途 | |
| JP5240756B2 (ja) | 軟骨疾患のモデル非ヒト動物 | |
| KR101917346B1 (ko) | Thrsp 과발현 형질전환 동물모델 및 이의 용도 | |
| WO2006016692A1 (ja) | ノックアウト非ヒト動物 | |
| WO2019161805A1 (en) | Hr knockout non-human animal | |
| CN114990128A (zh) | Cd20基因人源化非人动物的构建方法及应用 | |
| JP6323876B2 (ja) | ノックインマウス | |
| JP4217782B2 (ja) | ロスモンド・トムソン症候群の特徴を示すマウス及びその作製方法 |