JP2023521147A5 - - Google Patents

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Publication number
JP2023521147A5
JP2023521147A5 JP2022561637A JP2022561637A JP2023521147A5 JP 2023521147 A5 JP2023521147 A5 JP 2023521147A5 JP 2022561637 A JP2022561637 A JP 2022561637A JP 2022561637 A JP2022561637 A JP 2022561637A JP 2023521147 A5 JP2023521147 A5 JP 2023521147A5
Authority
JP
Japan
Prior art keywords
chimeric polypeptide
domain
polypeptide according
cell
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022561637A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023521147A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/026430 external-priority patent/WO2021207526A1/en
Publication of JP2023521147A publication Critical patent/JP2023521147A/ja
Publication of JP2023521147A5 publication Critical patent/JP2023521147A5/ja
Pending legal-status Critical Current

Links

JP2022561637A 2020-04-09 2021-04-08 ヒンジドメインを有するヒト化notch受容体 Pending JP2023521147A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007807P 2020-04-09 2020-04-09
US63/007,807 2020-04-09
US202163165588P 2021-03-24 2021-03-24
US63/165,588 2021-03-24
PCT/US2021/026430 WO2021207526A1 (en) 2020-04-09 2021-04-08 Humanized notch receptors with hinge domain

Publications (2)

Publication Number Publication Date
JP2023521147A JP2023521147A (ja) 2023-05-23
JP2023521147A5 true JP2023521147A5 (https=) 2024-04-17

Family

ID=78023652

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022561637A Pending JP2023521147A (ja) 2020-04-09 2021-04-08 ヒンジドメインを有するヒト化notch受容体

Country Status (10)

Country Link
US (1) US20230183709A1 (https=)
EP (1) EP4132659A4 (https=)
JP (1) JP2023521147A (https=)
KR (1) KR20220166833A (https=)
CN (1) CN115666726A (https=)
AU (1) AU2021251212A1 (https=)
BR (1) BR112022020415A2 (https=)
CA (1) CA3179954A1 (https=)
IL (1) IL297092A (https=)
WO (1) WO2021207526A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024537991A (ja) 2021-10-14 2024-10-18 アーセナル バイオサイエンシズ インコーポレイテッド 共発現されるshRNAと論理ゲートシステムとを有する免疫細胞
IL322949A (en) 2023-03-03 2025-10-01 Arsenal Biosciences Inc Systems targeting PSMA and CA9
AU2024260837A1 (en) * 2023-04-25 2025-10-16 Arsenal Biosciences, Inc. Novel receptors for transcription regulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333167B1 (en) * 2000-03-10 2001-12-25 American Home Products Corp. Methods and reagents for identifying inhibitors of proteolysis of membrane-associated proteins
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆-凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
WO2014145252A2 (en) * 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
KR102624023B1 (ko) * 2015-02-24 2024-01-11 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 결합-촉발된 전사 스위치 및 이들의 이용 방법
CN109843929B (zh) * 2016-08-23 2024-07-05 加利福尼亚大学董事会 蛋白水解可切割的嵌合多肽及其使用方法
US11325957B2 (en) * 2017-06-19 2022-05-10 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
WO2019217913A1 (en) * 2018-05-10 2019-11-14 Sensei Biotherapeutics, Inc. Aspartate beta-hydroxylase chimeric antigen receptors and uses thereof
CN114728172A (zh) * 2019-09-24 2022-07-08 加利福尼亚大学董事会 具有最小接头的Notch受体
EP4034251A4 (en) * 2019-09-24 2023-11-08 The Regents of the University of California Novel receptors having a heterologous stop transfer sequence for ligand-dependent transcriptional regulation
CN114728174A (zh) * 2019-09-24 2022-07-08 加利福尼亚大学董事会 具有异源跨膜结构域的受体
AU2020355031A1 (en) * 2019-09-24 2022-05-19 The Regents Of The University Of California Notch receptors with hinge domain
WO2021061791A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Notch receptors with zinc finger-containing transcriptional effector

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