JP2022516964A5 - - Google Patents

Info

Publication number
JP2022516964A5
JP2022516964A5 JP2021539876A JP2021539876A JP2022516964A5 JP 2022516964 A5 JP2022516964 A5 JP 2022516964A5 JP 2021539876 A JP2021539876 A JP 2021539876A JP 2021539876 A JP2021539876 A JP 2021539876A JP 2022516964 A5 JP2022516964 A5 JP 2022516964A5
Authority
JP
Japan
Prior art keywords
cancer
domain
human
cells
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021539876A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022516964A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/012589 external-priority patent/WO2020146393A1/en
Publication of JP2022516964A publication Critical patent/JP2022516964A/ja
Publication of JP2022516964A5 publication Critical patent/JP2022516964A5/ja
Pending legal-status Critical Current

Links

JP2021539876A 2019-01-07 2020-01-07 ガンマデルタt細胞を調節するためのヘテロ二量体タンパク質 Pending JP2022516964A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962789344P 2019-01-07 2019-01-07
US62/789,344 2019-01-07
US201962876346P 2019-07-19 2019-07-19
US62/876,346 2019-07-19
US201962941176P 2019-11-27 2019-11-27
US62/941,176 2019-11-27
PCT/US2020/012589 WO2020146393A1 (en) 2019-01-07 2020-01-07 Heterodimeric proteins for modulating gamma delta t cells

Publications (2)

Publication Number Publication Date
JP2022516964A JP2022516964A (ja) 2022-03-03
JP2022516964A5 true JP2022516964A5 (https=) 2023-01-20

Family

ID=71521410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021539876A Pending JP2022516964A (ja) 2019-01-07 2020-01-07 ガンマデルタt細胞を調節するためのヘテロ二量体タンパク質

Country Status (13)

Country Link
US (2) US20220025000A1 (https=)
EP (1) EP3902557A4 (https=)
JP (1) JP2022516964A (https=)
KR (1) KR20210113244A (https=)
CN (1) CN113329759A (https=)
AU (1) AU2020205965A1 (https=)
BR (1) BR112021013193A2 (https=)
CA (1) CA3125474A1 (https=)
IL (1) IL284658A (https=)
MX (1) MX2021008022A (https=)
PH (1) PH12021551475A1 (https=)
SG (1) SG11202106895UA (https=)
WO (1) WO2020146393A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023546725A (ja) * 2020-10-26 2023-11-07 シャタック ラボ,インコーポレイテッド ブチロフィリンを含むホモ二量体及びヘテロ二量体タンパク質
WO2022109110A1 (en) * 2020-11-19 2022-05-27 Shattuck Labs, Inc. Methods of identifying gamma delta t cell-modulating agents
AU2022238339A1 (en) * 2021-03-16 2023-10-26 Shattuck Labs, Inc. Gamma delta t-cell costimulation
WO2023154812A1 (en) * 2022-02-09 2023-08-17 Shattuck Labs, Inc. Multispecific heterodimeric proteins
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
WO2024191989A1 (en) * 2023-03-14 2024-09-19 Shattuck Labs, Inc. Treatment of b cell-mediated diseases by activating cd20-targeted gamma delta t cells

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003223601A1 (en) 2002-04-12 2003-10-27 King's College London ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN Beta 4
EP1536821A4 (en) 2002-06-17 2009-09-09 Wyeth Corp INHIBITION OF T CELL ACTIVATION BY BUTYROPHILIN A AND B7-L1
EP1702622A1 (en) 2005-03-18 2006-09-20 CONARIS research institute AG Soluble BTNL2 protein useful to inhibit inflammatory disorders
PT1999154E (pt) * 2006-03-24 2013-01-24 Merck Patent Gmbh Domínios proteicos heterodiméricos modificados
WO2008154516A2 (en) 2007-06-11 2008-12-18 The Board Of Regents, The Universtity Ot Texas System Btnl2 fusion protein for t-cell activity modulation
GB0717101D0 (en) 2007-09-03 2007-10-10 Cambridge Entpr Ltd Tumour marker
JP6157046B2 (ja) * 2008-01-07 2017-07-05 アムジェン インコーポレイテッド 静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法
US20130101590A1 (en) 2010-04-09 2013-04-25 Heather A. Arnett Btnl9 proteins, nucleic acids, and antibodies and uses thereof
KR101860963B1 (ko) * 2010-04-23 2018-05-24 제넨테크, 인크. 이종다량체 단백질의 생산
SG11201401422VA (en) * 2011-10-27 2014-09-26 Genmab As Production of heterodimeric proteins
WO2013098420A1 (en) 2011-12-28 2013-07-04 Immunoqure Ag Method of isolating human antibodies
US10131709B2 (en) 2011-12-28 2018-11-20 Immunoqure Ag Nucleic acid molecules encoding monoclonal antibodies specific for IL-22
EP2875046B2 (en) 2012-07-19 2025-04-30 Amgen Inc. Human btnl3 proteins, nucleic acids, and antibodies and uses thereof
WO2014106839A1 (en) 2013-01-01 2014-07-10 Kahr Medical Ltd. Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof
GB201300049D0 (en) 2013-01-03 2013-02-20 Transimmune Ag Method for obtaining immuno-stimulatory dendritic cells
GB201300052D0 (en) 2013-01-03 2013-02-20 Transimmune Ag Method for obtaining immuno-suppressive dendritic cells
JP6742237B2 (ja) 2013-07-03 2020-08-19 イムノキュア アーゲーImmunoqure Ag ヒト抗ifn−アルファ抗体
WO2015001047A1 (en) 2013-07-03 2015-01-08 Immunoqure Ag Method of providing anti-human cytokine antibodies for pharmaceutical use
AU2014286128B2 (en) 2013-07-03 2019-10-10 Immunoqure Ag Human anti-IL-32 antibodies
JP2016540046A (ja) 2013-11-29 2016-12-22 シーエスエル、リミテッド ガンの治療方法
DK3129404T3 (da) 2014-04-10 2026-04-20 Lava Therapeutics N V Immunglobuliner, der binder humane vgamma9vdelta2-t-cellereceptorer
GB201413665D0 (en) 2014-07-03 2014-09-17 Transimmune Ag And Yale University Method for obtaining globally activated monocytes
WO2016085662A1 (en) * 2014-11-25 2016-06-02 Albert Einstein College Of Medicine, Inc. Btnl9 and ermap as novel inhibitors of the immune system for immunotherapies
CN108064176A (zh) 2015-04-22 2018-05-22 库瑞瓦格股份公司 用于治疗肿瘤疾病的含有rna的组合物
US20180147257A1 (en) 2015-05-22 2018-05-31 The Board Of Trustees Of The Leland Stanford Junior University Btn3a ectodomain proteins and methods of use
JP6981973B2 (ja) * 2015-10-01 2021-12-17 ヒート バイオロジクス,インコーポレイテッド I型及びii型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法
WO2017072367A1 (en) 2015-10-30 2017-05-04 Cancer Research Technology Limited EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS
EP3383911B1 (en) 2015-12-02 2021-01-20 STCube & Co. Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
GB201521389D0 (en) * 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
CN116769054A (zh) * 2016-02-05 2023-09-19 奥里尼斯生物科学私人有限公司 双特异性信号传导剂及其用途
CN109071636A (zh) 2016-03-29 2018-12-21 斯特库比股份有限公司 用于选择特异性结合糖基化免疫检查点蛋白的抗体的方法
WO2018082590A1 (zh) * 2016-11-02 2018-05-11 北京蛋白质组研究中心 肿瘤免疫治疗靶标及其应用
WO2018201130A1 (en) 2017-04-28 2018-11-01 The Brigham And Women's Hospital, Inc. Targeting gamma-delta t cells in obesity and cachexia
CN111051346A (zh) 2017-05-31 2020-04-21 斯特库伯株式会社 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
KR20200015602A (ko) 2017-05-31 2020-02-12 주식회사 에스티큐브앤컴퍼니 Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도
KR20200026209A (ko) 2017-06-06 2020-03-10 주식회사 에스티큐브앤컴퍼니 Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
WO2018229163A1 (en) 2017-06-14 2018-12-20 King's College London Methods of activating v delta 2 negative gamma delta t cells
EP3681996B1 (en) 2017-09-15 2024-08-07 King's College London Compositions and methods for enhancing gamma delta t cells in the gut
KR102764182B1 (ko) 2017-09-21 2025-02-07 임체크 테라퓨틱스 Btn2에 대해 특이성을 갖는 항체 및 이의 용도
US11098093B2 (en) * 2019-01-07 2021-08-24 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta T cells

Similar Documents

Publication Publication Date Title
JP2022516964A5 (https=)
JP2023546725A5 (https=)
JP7438958B2 (ja) 新規な抗体分子、その調製方法及びその使用
JP2020530299A5 (https=)
CN111699197B (zh) 结合cd137的单结构域抗体
CN110121510B (zh) 程序性细胞死亡(pd-1)的单结构域抗体
JP7748933B2 (ja) 抗dll3キメラ抗原受容体及びその使用
JP2021502104A5 (https=)
JP2021503892A5 (https=)
JP2019523630A5 (https=)
RU2020120411A (ru) Триспецифические связывающие молекулы, направленные против опухолеассоциированных антигенов, и пути их применения
JP2012515556A5 (https=)
JP2020506727A5 (https=)
WO2018177371A1 (en) Antigen-specific t cells and uses thereof
WO2019114235A1 (zh) Pdl1单克隆抗体及其应用
WO2016115953A1 (zh) 一种靶向vegfr2的抗体融合蛋白的制备及其用途
JP2024543043A5 (https=)
WO2023115718A1 (zh) 抗pd-l1与ox40双特异性抗体及其用途
JP2023552093A (ja) ガンマデルタt細胞調節剤を同定する方法
JP2012518399A5 (https=)
CN114853897B (zh) 抗cd19/cd22/cd3三特异性抗体及用途
JP2022512539A5 (https=)
CN117247456A (zh) 靶向her2,pd-l1和vegf的三特异性抗体
WO2025081589A1 (zh) Cd4纳米抗体的制备及其应用
CN119894930A (zh) 一种双特异性抗体及其应用