KR20220166833A - 힌지 도메인을 갖는 인간화 노치 수용체 - Google Patents

힌지 도메인을 갖는 인간화 노치 수용체 Download PDF

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KR20220166833A
KR20220166833A KR1020227038985A KR20227038985A KR20220166833A KR 20220166833 A KR20220166833 A KR 20220166833A KR 1020227038985 A KR1020227038985 A KR 1020227038985A KR 20227038985 A KR20227038985 A KR 20227038985A KR 20220166833 A KR20220166833 A KR 20220166833A
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cell
gly
ser
ala
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콜 티. 로이발
레이몬드 리우
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더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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KR1020227038985A 2020-04-09 2021-04-08 힌지 도메인을 갖는 인간화 노치 수용체 Pending KR20220166833A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063007807P 2020-04-09 2020-04-09
US63/007,807 2020-04-09
US202163165588P 2021-03-24 2021-03-24
US63/165,588 2021-03-24
PCT/US2021/026430 WO2021207526A1 (en) 2020-04-09 2021-04-08 Humanized notch receptors with hinge domain

Publications (1)

Publication Number Publication Date
KR20220166833A true KR20220166833A (ko) 2022-12-19

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KR1020227038985A Pending KR20220166833A (ko) 2020-04-09 2021-04-08 힌지 도메인을 갖는 인간화 노치 수용체

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US (1) US20230183709A1 (https=)
EP (1) EP4132659A4 (https=)
JP (1) JP2023521147A (https=)
KR (1) KR20220166833A (https=)
CN (1) CN115666726A (https=)
AU (1) AU2021251212A1 (https=)
BR (1) BR112022020415A2 (https=)
CA (1) CA3179954A1 (https=)
IL (1) IL297092A (https=)
WO (1) WO2021207526A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022366987A1 (en) 2021-10-14 2024-05-16 Arsenal Biosciences, Inc. Immune cells having co-expressed shrnas and logic gate systems
KR20250158048A (ko) 2023-03-03 2025-11-05 아스널 바이오사이언시스, 인크. Psma 및 ca9을 표적으로 하는 시스템
CN121038806A (zh) * 2023-04-25 2025-11-28 阿森纳生物科学公司 用于转录调控的新颖受体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333167B1 (en) * 2000-03-10 2001-12-25 American Home Products Corp. Methods and reagents for identifying inhibitors of proteolysis of membrane-associated proteins
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
EP2970426B1 (en) * 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
WO2016138034A1 (en) * 2015-02-24 2016-09-01 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
JP7500195B2 (ja) * 2016-08-23 2024-06-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法
US11325957B2 (en) * 2017-06-19 2022-05-10 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
WO2019217913A1 (en) * 2018-05-10 2019-11-14 Sensei Biotherapeutics, Inc. Aspartate beta-hydroxylase chimeric antigen receptors and uses thereof
US20220340637A1 (en) * 2019-09-24 2022-10-27 The Regents Of The University Of California Notch receptors with minimal linker
WO2021061872A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Novel receptors having a heterologous stop transfer sequence for ligand-dependent transcriptional regulation
CN114761084B (zh) * 2019-09-24 2023-10-27 加利福尼亚大学董事会 具有铰链结构域的Notch受体
EP4034254A4 (en) * 2019-09-24 2023-11-01 The Regents of the University of California RECEPTORS WITH HETEROLOGUE TRANSMEMBRANE DOMAIN
WO2021061791A1 (en) * 2019-09-24 2021-04-01 The Regents Of The University Of California Notch receptors with zinc finger-containing transcriptional effector

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Publication number Publication date
WO2021207526A1 (en) 2021-10-14
CN115666726A (zh) 2023-01-31
EP4132659A1 (en) 2023-02-15
JP2023521147A (ja) 2023-05-23
BR112022020415A2 (pt) 2023-02-28
CA3179954A1 (en) 2021-10-14
IL297092A (en) 2022-12-01
AU2021251212A1 (en) 2022-11-03
US20230183709A1 (en) 2023-06-15
EP4132659A4 (en) 2024-06-12

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