|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
|
US4373071A
(en)
|
1981-04-30 |
1983-02-08 |
City Of Hope Research Institute |
Solid-phase synthesis of polynucleotides
|
|
US4401796A
(en)
|
1981-04-30 |
1983-08-30 |
City Of Hope Research Institute |
Solid-phase synthesis of polynucleotides
|
|
US5153319A
(en)
|
1986-03-31 |
1992-10-06 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5700642A
(en)
|
1995-05-22 |
1997-12-23 |
Sri International |
Oligonucleotide sizing using immobilized cleavable primers
|
|
EP1504126B1
(en)
|
2002-05-03 |
2014-02-26 |
Duke University |
A method of regulating gene expression
|
|
US8106180B2
(en)
*
|
2003-08-07 |
2012-01-31 |
Whitehead Institute For Biomedical Research |
Methods and products for expression of micro RNAs
|
|
WO2005017145A1
(ja)
|
2003-08-13 |
2005-02-24 |
Japan Biological Informatics Consortium |
機能性rnaが制御する被制御遺伝子の同定・予測方法及びその利用方法
|
|
US7795419B2
(en)
*
|
2004-05-26 |
2010-09-14 |
Rosetta Genomics Ltd. |
Viral and viral associated miRNAs and uses thereof
|
|
US20070099196A1
(en)
|
2004-12-29 |
2007-05-03 |
Sakari Kauppinen |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
WO2006133022A2
(en)
|
2005-06-03 |
2006-12-14 |
The Johns Hopkins University |
Compositions and methods for decreasing microrna expression for the treatment of neoplasia
|
|
ITMI20051248A1
(it)
|
2005-07-01 |
2007-01-02 |
Vimar Spa |
Modem per bus per impianti elettrici civili ed industriali
|
|
CA2621441C
(en)
|
2005-09-12 |
2014-05-20 |
The Ohio State University Research Foundation |
Compositions and methods for the diagnosis and therapy of bcl2-associated cancers
|
|
US8603991B2
(en)
|
2005-11-18 |
2013-12-10 |
Gradalis, Inc. |
Individualized cancer therapy
|
|
CN101448942B
(zh)
|
2005-12-12 |
2014-04-23 |
北卡罗来纳大学查珀尔希尔分校 |
调节肌细胞增殖和分化的microrna
|
|
EP2484782B1
(en)
|
2006-01-05 |
2015-11-18 |
The Ohio State University Research Foundation |
MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
|
|
WO2007143752A2
(en)
|
2006-06-09 |
2007-12-13 |
The Regents Of The University Of California |
Targets in breast cancer for prognosis or therapy
|
|
WO2007149521A2
(en)
|
2006-06-20 |
2007-12-27 |
The Johns Hopkins University |
Nucleotide motifs providing localization elements and methods of use
|
|
WO2008069940A2
(en)
|
2006-12-06 |
2008-06-12 |
Albert Einstein College Of Medicine Of Yeshiva University |
Multi-microrna methods and compositions
|
|
WO2008088858A2
(en)
|
2007-01-17 |
2008-07-24 |
The Johns Hopkins University |
Compositions and methods featuring micronas for treating neoplasia
|
|
WO2009012263A2
(en)
*
|
2007-07-18 |
2009-01-22 |
The Trustees Of Columbia University In The City Of New York |
Tissue-specific micrornas and compositions and uses thereof
|
|
NZ583025A
(en)
|
2007-07-31 |
2012-06-29 |
Univ Texas |
Micro-rnas that control myosin expression and myofiber identity
|
|
WO2009075817A1
(en)
|
2007-12-06 |
2009-06-18 |
Minerva Biotechnologies Corporation |
Method for treating cancer using interference rna
|
|
JP2010094122A
(ja)
|
2008-06-12 |
2010-04-30 |
Keio Gijuku |
バイオマーカーとしてのマイクロrnaを用いた頭頸部腫瘍の診断・治療選択
|
|
WO2010065630A2
(en)
|
2008-12-03 |
2010-06-10 |
The Johns Hopkins University |
Compositions and methods for treating hepatic neoplasia
|
|
AU2010258875A1
(en)
|
2009-06-08 |
2012-01-19 |
Miragen Therapeutics |
Chemical modification motifs for miRNA inhibitors and mimetics
|
|
US8796238B2
(en)
|
2009-09-17 |
2014-08-05 |
Sigma-Aldrich Co. Llc |
Short RNA mimetics
|
|
US20120302626A1
(en)
*
|
2009-12-04 |
2012-11-29 |
Sandeep Dave |
Microrna and use thereof in identification of b cell malignancies
|
|
US8768630B2
(en)
*
|
2010-02-19 |
2014-07-01 |
The Regents Of The University Of Michigan |
miRNA target prediction
|
|
MX373121B
(es)
|
2010-05-14 |
2020-04-30 |
Dana Farber Cancer Inst Inc |
Composiciones y metodos para el tratamiento de leucemia.
|
|
EP2426203B1
(en)
|
2010-09-02 |
2016-07-13 |
Université de Mons |
Agents useful in treating facioscapulohumeral muscular dystrophy
|
|
JP2014506789A
(ja)
|
2011-02-03 |
2014-03-20 |
マーナ セラピューティクス インコーポレイテッド |
miR−124の合成模倣体
|
|
WO2012106591A1
(en)
|
2011-02-03 |
2012-08-09 |
Mirna Therapeutics, Inc. |
Synthetic mimics of mir-34
|
|
AU2012286994B2
(en)
*
|
2011-07-25 |
2017-08-10 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of DUX4
|
|
US20140242093A1
(en)
|
2011-07-29 |
2014-08-28 |
Fred Hutchinson Cancer Research Center |
Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject
|
|
CA2850223A1
(en)
|
2011-10-06 |
2013-04-11 |
Eva Van Rooij |
Control of whole body energy homeostasis by microrna regulation
|
|
US8846633B2
(en)
|
2011-11-07 |
2014-09-30 |
Taipei Veterans General Hospital |
Method for inhibiting cancer stem cell like properties and chemoradioresistant properties of cancer or tumor cells with microRNA145
|
|
WO2013120038A2
(en)
|
2012-02-10 |
2013-08-15 |
Regents Of The University Of Minnesota |
Morpholino targeting dux4 for treating fshd
|
|
WO2013120497A1
(en)
*
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
|
|
CN112007045B
(zh)
*
|
2012-07-13 |
2026-01-06 |
波涛生命科学有限公司 |
手性控制
|
|
WO2014179765A2
(en)
*
|
2013-05-02 |
2014-11-06 |
Thomas Jefferson University |
Novel human mirnas for use in diagnosis, prognosis and therapy of human conditions and diseases
|
|
US9518300B2
(en)
|
2014-04-14 |
2016-12-13 |
Dana-Farber Cancer Institute, Inc. |
Composition and method for treating a hematological malignancy
|
|
ES2744186T3
(es)
|
2014-04-25 |
2020-02-24 |
Childrens Medical Center |
Composiciones y métodos para tratar las hemoglobinopatías
|
|
WO2016115490A1
(en)
*
|
2015-01-16 |
2016-07-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of dux4
|
|
US20180305689A1
(en)
|
2015-04-22 |
2018-10-25 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
IL318703A
(en)
*
|
2015-06-29 |
2025-03-01 |
Caris Science Inc |
Therapeutic oligonucleotides
|
|
US20170009230A1
(en)
|
2015-07-08 |
2017-01-12 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting dux4 gene expression and uses thereof
|
|
DK3426781T3
(da)
*
|
2016-03-07 |
2024-09-30 |
Us Health |
Mikro-rna'er og fremgangsmåder til anvendelse deraf
|
|
WO2017173411A1
(en)
*
|
2016-04-02 |
2017-10-05 |
Research Institute At Nation Wide Children's Hospital |
Modified u6 promoter system for tissue specific expression
|
|
CA3099522C
(en)
*
|
2017-09-19 |
2024-10-08 |
The Governors Of The University Of Alberta |
GAPMERES AND METHODS OF USING THESE FOR THE TREATMENT OF MUSCULAR DYSTROPHY
|
|
EP3668997A4
(en)
|
2017-10-02 |
2021-05-19 |
Research Institute at Nationwide Children's Hospital |
SYSTEM FOR MIRNA DETARGETING FOR TISSUE-SPECIFIC INTERFERENCE
|
|
US10676744B2
(en)
*
|
2017-10-13 |
2020-06-09 |
University Of South Carolina |
Modulation of adipose tissue macrophage phenotype by use of MicroRNA-30
|
|
US11268305B2
(en)
|
2018-05-17 |
2022-03-08 |
Kiekert Ag |
Latching system for a motor vehicle
|
|
WO2020028134A1
(en)
*
|
2018-07-30 |
2020-02-06 |
Fred Hutchinson Cancer Research Center |
Methods and compositions for treating cancer
|
|
US20220193250A1
(en)
|
2018-08-02 |
2022-06-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
IL326747A
(en)
*
|
2018-11-02 |
2026-04-01 |
Biomarin Tech Bv |
Bispecific antisense oligonucleotides for dystrophin exon skipping
|
|
BR112021018793A2
(pt)
|
2019-03-29 |
2021-11-23 |
Mitsubishi Tanabe Pharma Corp |
Oligonucleotídeo modificado, composição farmacêutica compreendendo o mesmo composto para modular a expressão de dux4 e uso
|
|
US20220364086A1
(en)
|
2019-07-12 |
2022-11-17 |
Daiichi Sankyo Company, Limited |
ANTISENSE OLIGONUCLEOTIDE CAPABLE OF ALTERING SPLICING OF DUX4 pre-mRNA
|
|
US20230088865A1
(en)
|
2020-01-10 |
2023-03-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
WO2021188390A1
(en)
|
2020-03-19 |
2021-09-23 |
Avidity Biosciences, Inc. |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
|
WO2021211325A1
(en)
|
2020-04-17 |
2021-10-21 |
Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno |
Crispr-inhibition for facioscapulohumeral muscular dystrophy
|
|
GB202009618D0
(en)
|
2020-06-24 |
2020-08-05 |
Ucl Business Ltd |
Therapeutics for the treatment of FSHD
|
|
CN116348139A
(zh)
|
2020-07-23 |
2023-06-27 |
达因疗法公司 |
肌肉靶向复合物及其用于治疗面肩肱型肌营养不良的用途
|
|
AU2021313058A1
(en)
|
2020-07-23 |
2023-03-30 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof
|
|
JP7736329B2
(ja)
|
2020-08-31 |
2025-09-09 |
株式会社モダリス |
Dux4遺伝子を標的とした顔面肩甲上腕型筋ジストロフィーの治療方法
|
|
WO2022043566A1
(en)
|
2020-08-31 |
2022-03-03 |
Merck Patent Gmbh |
Method and device for manufacturing of solid oral dosage forms
|
|
CA3189861A1
(en)
|
2020-09-01 |
2022-03-10 |
Sean Christopher DAUGHERTY |
Dux4 inhibitors and methods of use thereof
|
|
JP2023541427A
(ja)
|
2020-09-11 |
2023-10-02 |
アローヘッド ファーマシューティカルズ インコーポレイテッド |
骨格筋送達プラットフォーム及び使用方法
|
|
AU2021342155A1
(en)
|
2020-09-11 |
2023-04-13 |
Arrowhead Pharmaceuticals, Inc. |
RNAi agents for inhibiting expression of DUX4, compositions thereof, and methods of use
|
|
JP2022055361A
(ja)
|
2020-09-28 |
2022-04-07 |
田辺三菱製薬株式会社 |
Dux4の発現を調節するための医薬組成物
|