BR112022019889A2 - Inibição direcionada com o uso de oligonucleotídeos modificados geneticamente - Google Patents

Inibição direcionada com o uso de oligonucleotídeos modificados geneticamente

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Publication number
BR112022019889A2
BR112022019889A2 BR112022019889A BR112022019889A BR112022019889A2 BR 112022019889 A2 BR112022019889 A2 BR 112022019889A2 BR 112022019889 A BR112022019889 A BR 112022019889A BR 112022019889 A BR112022019889 A BR 112022019889A BR 112022019889 A2 BR112022019889 A2 BR 112022019889A2
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Brazil
Prior art keywords
genetically modified
modified oligonucleotides
targeted inhibition
activity
disclosed
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BR112022019889A
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English (en)
Inventor
Place Robert
Saleh Anthony
Williams Tishan
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Mirecule Inc
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Publication of BR112022019889A2 publication Critical patent/BR112022019889A2/pt

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Abstract

INIBIÇÃO DIRECIONADA COM O USO DE OLIGONUCLEOTÍDEOS MODIFICADOS GENETICAMENTE. São divulgados aqui oligonucleotídeos projetados para inibição seletiva da expressão e atividade de polipeptídeos. Também são divulgados neste documento métodos para inibir seletivamente a expressão e a atividade do polipeptídeo contatando um oligonucleotídeo manipulado com um polinucleotídeo que codifica o polipeptídeo.
BR112022019889A 2020-04-02 2021-04-02 Inibição direcionada com o uso de oligonucleotídeos modificados geneticamente BR112022019889A2 (pt)

Applications Claiming Priority (2)

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US202063004045P 2020-04-02 2020-04-02
PCT/US2021/025639 WO2021203043A2 (en) 2020-04-02 2021-04-02 Targeted inhibition using engineered oligonucleotides

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BR112022019889A2 true BR112022019889A2 (pt) 2023-03-07

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US (4) US20230132602A1 (pt)
EP (1) EP4127175A2 (pt)
JP (1) JP2023521042A (pt)
KR (1) KR20230023612A (pt)
CN (1) CN116096890A (pt)
AU (1) AU2021246530A1 (pt)
BR (1) BR112022019889A2 (pt)
CA (1) CA3174286A1 (pt)
CO (1) CO2022015141A2 (pt)
IL (1) IL296957A (pt)
MX (1) MX2022012265A (pt)
WO (1) WO2021203043A2 (pt)

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