JP2023510778A5 - - Google Patents

Info

Publication number
JP2023510778A5
JP2023510778A5 JP2022542118A JP2022542118A JP2023510778A5 JP 2023510778 A5 JP2023510778 A5 JP 2023510778A5 JP 2022542118 A JP2022542118 A JP 2022542118A JP 2022542118 A JP2022542118 A JP 2022542118A JP 2023510778 A5 JP2023510778 A5 JP 2023510778A5
Authority
JP
Japan
Prior art keywords
compound according
alkyl groups
optionally
membered
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022542118A
Other languages
English (en)
Japanese (ja)
Other versions
JP7791822B2 (ja
JP2023510778A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/012282 external-priority patent/WO2021141969A1/en
Publication of JP2023510778A publication Critical patent/JP2023510778A/ja
Publication of JP2023510778A5 publication Critical patent/JP2023510778A5/ja
Priority to JP2025160231A priority Critical patent/JP2026016394A/ja
Application granted granted Critical
Publication of JP7791822B2 publication Critical patent/JP7791822B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022542118A 2020-01-09 2021-01-06 ナノマテリアル Active JP7791822B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025160231A JP2026016394A (ja) 2020-01-09 2025-09-26 ナノマテリアル

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062958876P 2020-01-09 2020-01-09
US62/958,876 2020-01-09
PCT/US2021/012282 WO2021141969A1 (en) 2020-01-09 2021-01-06 Nanomaterials

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025160231A Division JP2026016394A (ja) 2020-01-09 2025-09-26 ナノマテリアル

Publications (3)

Publication Number Publication Date
JP2023510778A JP2023510778A (ja) 2023-03-15
JP2023510778A5 true JP2023510778A5 (enExample) 2024-01-17
JP7791822B2 JP7791822B2 (ja) 2025-12-24

Family

ID=76788721

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022542118A Active JP7791822B2 (ja) 2020-01-09 2021-01-06 ナノマテリアル
JP2025160231A Pending JP2026016394A (ja) 2020-01-09 2025-09-26 ナノマテリアル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025160231A Pending JP2026016394A (ja) 2020-01-09 2025-09-26 ナノマテリアル

Country Status (11)

Country Link
US (2) US12435035B2 (enExample)
EP (1) EP4103542A4 (enExample)
JP (2) JP7791822B2 (enExample)
KR (1) KR20220123536A (enExample)
CN (2) CN119684140A (enExample)
AU (1) AU2021205837A1 (enExample)
BR (1) BR112022013599A2 (enExample)
CA (1) CA3163161A1 (enExample)
IL (1) IL294318A (enExample)
MX (1) MX2022008455A (enExample)
WO (1) WO2021141969A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3145913A1 (en) 2019-07-29 2021-02-04 James Everett Dahlman Nanomaterials containing constrained lipids and uses thereof
IL294318A (en) 2020-01-09 2022-08-01 Guide Therapeutics Llc Nanomaterials
KR20230041726A (ko) 2020-07-15 2023-03-24 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 필터 매체의 재생 및 연도 가스의 세정 방법
JP2023549011A (ja) 2020-09-15 2023-11-22 ヴァーヴ・セラピューティクス,インコーポレーテッド 遺伝子編集のための脂質製剤
EP4228658A4 (en) 2020-10-14 2025-02-19 George Mason Research Foundation, Inc. IONIZABLE LIPIDS AND METHODS FOR THE PRODUCTION AND USE THEREOF
EP4262819A4 (en) * 2020-12-21 2024-12-04 Beam Therapeutics Inc. NANOMATERIALS WITH ESTER-BOUND ACETALS
CN116761888A (zh) 2021-01-20 2023-09-15 比姆医疗股份有限公司 纳米材料
EP4281080A4 (en) * 2021-01-20 2025-09-24 Beam Therapeutics Inc NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT
US20240180954A1 (en) * 2021-02-04 2024-06-06 Shionogi & Co., Ltd. Cationic lipid
JP2024536406A (ja) * 2021-10-08 2024-10-04 スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド 脂質化合物及び脂質ナノ粒子組成物
CA3248846A1 (en) * 2022-01-17 2023-07-20 Sanofi Lipid Compounds and Their Uses
WO2023230601A1 (en) 2022-05-27 2023-11-30 Beam Therapeutics Inc. Identification of nanoparticles for preferential tissue or cell targeting
CA3260437A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. NANOMATERIALS INCLUDING TRIOLS
WO2024199282A1 (zh) * 2023-03-28 2024-10-03 苏州艾博生物科技有限公司 脂质化合物和脂质纳米颗粒组合物
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025038864A1 (en) * 2023-08-16 2025-02-20 Beam Therapeutics Inc. Ionizable lipids with linear head groups
CN119490447A (zh) * 2023-08-17 2025-02-21 苏州星核迪赛生物技术有限公司 药物递送材料及其应用
WO2025166314A1 (en) * 2024-02-02 2025-08-07 Tessera Therapeutics, Inc. Ex vivo delivery of lipid nanoparticles for delivery of gene modifying systems to t cells
WO2025212851A2 (en) 2024-04-03 2025-10-09 Orbital Therapeutics, Inc. mRNA COMPOSITIONS AND USES THEREOF IN VARICELLA ZOSTER VIRUS VACCINES
WO2025259931A1 (en) 2024-06-14 2025-12-18 Orbital Therapeutics, Inc. Compositions and methods for rna circularization
WO2026006203A2 (en) 2024-06-24 2026-01-02 Orbital Therapeutics, Inc. Compositions and methods for making circular rna
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
WO2026006687A1 (en) 2024-06-28 2026-01-02 Orbital Therapeutics, Inc. Circular rna compositions and uses thereof for diseases caused by varicella-zoster virus

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL257307A (enExample) 1959-10-28
US3686238A (en) 1970-01-19 1972-08-22 Syntex Corp Glycerol esterified with 2-naphthyl-acetic acids and fatty acids
US20030083272A1 (en) 1997-09-19 2003-05-01 Lahive & Cockfield, Llp Sense mrna therapy
US6670499B1 (en) 1999-11-08 2003-12-30 Daicel Chemical Industries, Ltd. Adamantane derivatives and processes for the preparation thereof
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
US20040077888A1 (en) 2002-05-31 2004-04-22 The Regents Of The University Of California Polyamine-mediated transfection
JP2005181734A (ja) 2003-12-19 2005-07-07 Fuji Photo Film Co Ltd 画像記録材料
DE102007029471A1 (de) 2007-06-20 2008-12-24 Novosom Ag Neue fakultativ kationische Sterole
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
KR20190039347A (ko) 2010-06-03 2019-04-10 알닐람 파마슈티칼스 인코포레이티드 활성제의 전달을 위한 생분해성 지질
PE20181541A1 (es) 2011-10-27 2018-09-26 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
WO2013086354A1 (en) 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
CN107879960B (zh) 2013-03-08 2021-06-22 诺华股份有限公司 用于传递活性成分的脂质和脂质组合物
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
EP3083556B1 (en) 2013-12-19 2019-12-25 Novartis AG Lipids and lipid compositions for the delivery of active agents
US10426737B2 (en) 2013-12-19 2019-10-01 Novartis Ag Lipids and lipid compositions for the delivery of active agents
US10125092B2 (en) 2014-09-05 2018-11-13 Novartis Ag Lipids and lipid compositions for the delivery of active agents
ES2880103T3 (es) 2015-05-21 2021-11-23 Ohio State Innovation Foundation Derivados de benceno-1, 3, 5-tricarboxamida y usos de los mismos
JP6948313B6 (ja) 2015-09-17 2022-01-14 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物および組成物
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
HRP20230209T1 (hr) * 2015-10-28 2023-04-14 Acuitas Therapeutics Inc. Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
LT3436077T (lt) 2016-03-30 2025-06-25 Intellia Therapeutics, Inc. Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams
MY206271A (en) 2016-07-11 2024-12-06 Opko Biologics Ltd Long-acting coagulation factor vii and methods of producing same
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
EP4186888B1 (en) * 2017-03-15 2025-11-26 ModernaTX, Inc. Compound and compositions for intracellular delivery of therapeutic agents
BR112019025104A2 (pt) 2017-05-30 2020-06-23 Glaxosmithkline Biologicals S.A. Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição
CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
CA3081414A1 (en) 2017-10-30 2019-05-09 Georgia Tech Research Corporation Multiplexed analysis of materials for tissue delivery
US11622942B2 (en) 2017-11-14 2023-04-11 Ohio State Innovation Foundation Benzene-1,3,5-tricarboxamide derived ester lipids and uses thereof
EP3727362A4 (en) 2017-12-19 2021-10-06 PureTech LYT, Inc. MYCOPHENOLIC ACID LIPID PRODRUGS AND THEIR USES
TWI894123B (zh) 2017-12-27 2025-08-21 日商武田藥品工業有限公司 含核酸之脂質奈米粒子及其用途
CN112955099B (zh) 2018-07-27 2024-04-26 雷森斯医疗有限公司 医疗冷却装置和使用其的冷却方法
CA3107481A1 (en) 2018-08-02 2020-02-06 Puretech Lyt, Inc. Lipid prodrugs of pregnane neurosteroids and uses thereof
EP3842538A4 (en) 2018-08-10 2022-06-08 Kyoto University METHOD OF TRANSFECTION INTO CARDIOMYOCYTES USING CATIONIC LIPID
US20220009878A1 (en) 2018-10-02 2022-01-13 Intellia Therapeutics, Inc. Ionizable amine lipids
BR112021010853A2 (pt) 2018-12-05 2021-08-31 Intellia Therapeutics, Inc. Lipídios de amina modificados
CN119700703A (zh) 2019-01-17 2025-03-28 佐治亚技术研究公司 含有氧化的胆固醇的药物递送系统
US11845874B2 (en) 2019-01-24 2023-12-19 Agfa Nv Radiation curable inkjet inks for interior decoration
JP7693552B2 (ja) 2019-02-13 2025-06-17 ビーム セラピューティクス インク. アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法
CA3130349A1 (en) 2019-02-28 2020-09-03 Puretech Lyt, Inc. Lipid prodrugs of jak inhibitors and uses thereof
WO2020176856A1 (en) 2019-02-28 2020-09-03 Puretech Lyt, Inc. Lipid prodrugs of glucocorticoids and uses thereof
WO2020176868A1 (en) 2019-02-28 2020-09-03 Puretech Lyt, Inc. Lipid prodrugs of btk inhibitors and uses thereof
CN114127044A (zh) * 2019-04-25 2022-03-01 英特利亚治疗股份有限公司 可电离的胺类脂质和脂质纳米颗粒
JP2022536112A (ja) 2019-06-05 2022-08-12 ガイド セラピューティクス,インコーポレーテッド 組織送達のための材料の分析
WO2020246581A1 (ja) 2019-06-07 2020-12-10 富士フイルム株式会社 脂質組成物
WO2021021636A1 (en) 2019-07-29 2021-02-04 Georgia Tech Research Corporation Oligonucleotide antagonists for rna guided genome editing
CA3145913A1 (en) 2019-07-29 2021-02-04 James Everett Dahlman Nanomaterials containing constrained lipids and uses thereof
CN114901799A (zh) 2019-10-21 2022-08-12 弗拉斯沃克斯有限责任公司 用于细胞培养的系统和方法
KR20220113737A (ko) 2019-12-06 2022-08-16 가이드 테라퓨틱스 엘엘씨 나노물질
IL294318A (en) 2020-01-09 2022-08-01 Guide Therapeutics Llc Nanomaterials
JP2024503976A (ja) 2020-12-21 2024-01-30 ビーム セラピューティクス インク. アセタールを含むナノ材料
EP4262818A4 (en) 2020-12-21 2025-03-26 Beam Therapeutics Inc. NANOMATERIALS WITH CARBONATES
EP4262819A4 (en) 2020-12-21 2024-12-04 Beam Therapeutics Inc. NANOMATERIALS WITH ESTER-BOUND ACETALS
EP4281080A4 (en) 2021-01-20 2025-09-24 Beam Therapeutics Inc NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT
CN116761888A (zh) 2021-01-20 2023-09-15 比姆医疗股份有限公司 纳米材料
JP2024503441A (ja) 2021-01-20 2024-01-25 ビーム セラピューティクス インク. イオン化可能な脂質を含むナノ材料
CA3203784A1 (en) 2021-01-20 2022-07-28 Beam Therapeutics Inc. Ionizable lipids for nanomaterials
EP4351651A1 (en) 2021-05-28 2024-04-17 Renagade Therapeutics Management Inc. Lipid nanoparticles and methods of use thereof
JP2024536406A (ja) 2021-10-08 2024-10-04 スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド 脂質化合物及び脂質ナノ粒子組成物
CA3241488A1 (en) 2021-12-20 2023-06-29 Beam Therapeutics Inc. Ionizable amine lipids and lipid nanoparticles
EP4452925A1 (en) 2021-12-20 2024-10-30 Beam Therapeutics Inc. Nanomaterial comprising diamines
EP4452942A1 (en) 2021-12-20 2024-10-30 Beam Therapeutics Inc. Nanomaterials comprising disulfides
WO2023121970A1 (en) 2021-12-20 2023-06-29 Beam Therapeutics Inc. Ionizable amine and ester lipids and lipid nanoparticles
JP2025500824A (ja) 2021-12-20 2025-01-15 ビーム セラピューティクス インク. 四価脂質化合物を含むナノ材料
CA3260437A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. NANOMATERIALS INCLUDING TRIOLS

Similar Documents

Publication Publication Date Title
JP2023510778A5 (enExample)
JP2023505316A5 (enExample)
JP2025181861A5 (enExample)
AU2023200568C1 (en) Novel lipids and compositions for the delivery of therapeutics
CA2767129C (en) Compositions and methods for silencing apolipoprotein b
CN104004018B (zh) 具有含氮脂环式骨架的单链核酸分子
CN111343994B (zh) 用于抑制血管生成素-样3 (ANGPTL3)的表达的RNAi剂和组合物以及使用方法
AU2022268351A1 (en) Di-aliphatic substituted pegylated lipids
CN109562188B (zh) 与三价糖缀合物连接的核酸
JP7748500B2 (ja) トリループを含む二本鎖核酸インヒビター分子
ES3017428T3 (en) Ionizable cationic lipids for lipid nanoparticles
Nawrot et al. Chemical and structural diversity of siRNA molecules
JP6422961B2 (ja) 改善された高効率ナノ粒子型オリゴヌクレオチド構造体およびその製造方法
CA2685127A1 (en) Glycoconjugates of rna interference agents
RS58077B1 (sr) Trialkil katjonski lipidi i postupci njihove primene
RU2020135289A (ru) Применение ингибиторов fubp1 для лечения инфекции вирусом гепатита в
WO2019074110A1 (ja) 一本鎖核酸分子およびその製造方法
KR20220004675A (ko) 단축 센스 가닥을 갖는 이중 가닥 핵산 억제제 분자
JP2024508780A5 (enExample)
JP2024509906A5 (enExample)
TWI871840B (zh) 合成4'-磷酸鹽類似物核苷酸亞磷醯胺之方法
RU2026104839A (ru) Мультивалентные комплексы, несущие полезную нагрузку, и их применение
KR20260042246A (ko) 다가 카고 함유 복합체 및 이의 용도
RU2020118025A (ru) Нуклеиновая кислота, композиция и конъюгат, содержащие ее, а также способ их получения и применения
ES2368300B1 (es) Derivados lipofílicos de ácidos nucleicos.