JP2023510655A - アスパラギン酸アルギニンを含む加齢臭抑制用組成物 - Google Patents
アスパラギン酸アルギニンを含む加齢臭抑制用組成物 Download PDFInfo
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- JP2023510655A JP2023510655A JP2022568367A JP2022568367A JP2023510655A JP 2023510655 A JP2023510655 A JP 2023510655A JP 2022568367 A JP2022568367 A JP 2022568367A JP 2022568367 A JP2022568367 A JP 2022568367A JP 2023510655 A JP2023510655 A JP 2023510655A
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- Prior art keywords
- arginine aspartate
- nonenal
- present
- aging odor
- suppressing aging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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Abstract
Description
本発明は、アスパラギン酸アルギニンを含む加齢臭抑制用組成物に係り、より詳しくは、アスパラギン酸アルギニンを含んで2-ノネナールを除去することで加齢臭を抑制することができる組成物に関する。
体内老廃物は身体の老化による新陳代謝能力の低下で分解や排出機能が滑らかに行われなくて体内に溜まる。2-ノネナール(2-nonenal)という物質は中高齢の男性の体臭の原因の一つであって、特に背中、胸などから多量発生する。
〔発明が解決しようとする課題〕
本発明者らは、加齢臭の主な原因である2-ノネナールを分解又は除去する素材を開発するために鋭意研究検討を重ねた結果、アスパラギン酸アルギニン(arginine aspartate)が効果的に2-ノネナールを除去して加齢臭を抑制することができることを見出し、さらにアスパラギン酸アルギニンが加齢臭抑制効能の他にもしわ改善、抗炎症、又は美白効能を持つことを確認し本発明を完成するに至った。
本発明の一実施形態は、アスパラギン酸アルギニンを含む、加齢臭抑制、しわ改善、抗炎症、又は美白用化粧料組成物に関する。
本発明に係る化粧料組成物は、前記アスパラギン酸アルギニンの他、化粧料組成物に通常用いられる成分、例えば、抗酸化剤、安定化剤、溶解化剤、ビタミン、顔料、及び香料のような通常の補助剤、そして、担体を含む。
本発明に係るアスパラギン酸アルギニンは、2-ノネナールを低減させるだけでなく、MMP-1(Matrix metalloproteinase-1)の発現を阻害し、コラーゲン合成能を有し、TNF-αの発現を低減させ、チロシナーゼの活性を抑制することができ、加齢臭抑制、しわ改善、抗炎症、又は美白用組成物に効果的に用いられ得る。
〔図1〕アスパラギン酸アルギニンの2-ノネナール除去能評価結果を示したグラフである。
以下、実施例によって本発明をより具体的に説明することにする。なお、これらの実施例は単に本発明を説明するためのものであって、本発明の範囲がこれらの実施例に局限されないことは当業者にとって自明である。
本発明に係る化学式1で表されるアスパラギン酸アルギニンの2-ノネナール除去能を評価した。
ヒト皮膚線維芽細胞を1×104/wellの濃度で培養した。前記細胞にアスパラギン酸アルギニンを濃度別に処理しPCR機器を用いてMMP-1発現量を測定してMMP-1阻害能を評価した。試料を処理していないものを対照群(CON)とし、陽性対照群としてアデノシン50ppmを処理した。その結果を下記の表1に表した。
ヒト皮膚線維芽細胞を1×104/wellの濃度で培養した。前記細胞にそれぞれの試料を処理しコラーゲン合成量を測定してコラーゲン合成能を評価した。陽性対照群としてのアデノシンは50ppm濃度で、アスパラギン酸アルギニンは10、20及び40ppm濃度で処理した。コラーゲン定量は、タイプ1プロコラーゲンC-ペプチドEIAキット(Type I Procollagen C-Peptide EIA kit)(Takara、Japan)を用いて行った。試料を処理していない場合を対照群(CON)とした。その結果を下記の表2に表した。
HaCaT細胞を12ウェルプレートに1×105cells/wellずつシーディング(seeding)し24時間後に基本培地(basal medium)に取り替えて、6時間飢餓(starvation)処理を施した。その後、試料を含有した基本培地に取り替えて24時間培養した。培地を除去した後にUVBで刺激を与え、基本培地を入れて24時間培養した。培地を完全に除去しPBSを用いて2回洗浄した。TRIsureを用いて細胞を破砕してRNAを回収してからRT-PCRを施してTNF-αを増幅した。アガロースゲルで電気泳動しゲルドキュメンテーションシステム(Gel Documentation system)を用いて発現率を測定した。陽性対照群として200μMデキサメタゾンを用いた。その結果を下記の表3に表した。
エッペンチューブに0.1Mリン酸塩バッファー(pH6.8)200μLを添加した後、濃度別に希釈した試料液を20μLずつ入れた。これにマッシュルームチロシナーゼ(mushroom tyrosinase)(2,000unit/μL)20μLを添加した後、0.3%チロシン200μLを順に入れてから37℃で10分間反応させた。この液を96ウェルプレートに200μL移した後、ELISAリーダーを用いて490nmにおける吸光度を測定した。陽性対照群として100ppmアルブチンを用いた。その結果を下記の表4に表した。
Claims (9)
- アスパラギン酸アルギニンを含む、加齢臭抑制、しわ改善、抗炎症、又は美白用化粧料組成物。
- 2-ノネナールを低減させる、請求項1に記載の加齢臭抑制用化粧料組成物。
- アスパラギン酸アルギニンを含む、加齢臭抑制、しわ改善、抗炎症、又は美白用薬剤学的組成物。
- 2-ノネナールを低減させる、請求項4に記載の加齢臭抑制用薬剤学的組成物。
- アスパラギン酸アルギニンを含む、加齢臭抑制、しわ改善、抗炎症、又は美白用健康機能食品。
- 2-ノネナールを低減させる、請求項7に記載の加齢臭抑制用健康機能食品。
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PCT/KR2021/000470 WO2021145672A1 (ko) | 2020-01-15 | 2021-01-13 | 알지닌 아스파테이트를 포함하는 노인성 체취 억제용 조성물 |
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