JP2023508982A5 - - Google Patents
Info
- Publication number
- JP2023508982A5 JP2023508982A5 JP2022539129A JP2022539129A JP2023508982A5 JP 2023508982 A5 JP2023508982 A5 JP 2023508982A5 JP 2022539129 A JP2022539129 A JP 2022539129A JP 2022539129 A JP2022539129 A JP 2022539129A JP 2023508982 A5 JP2023508982 A5 JP 2023508982A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- alkyl
- represented
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962953381P | 2019-12-24 | 2019-12-24 | |
| US62/953,381 | 2019-12-24 | ||
| PCT/US2020/066811 WO2021133896A1 (en) | 2019-12-24 | 2020-12-23 | Transcriptional enhanced associate doman (tead) transcription factor inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023508982A JP2023508982A (ja) | 2023-03-06 |
| JP2023508982A5 true JP2023508982A5 (https=) | 2023-12-28 |
| JP7671293B2 JP7671293B2 (ja) | 2025-05-01 |
Family
ID=76575114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022539129A Active JP7671293B2 (ja) | 2019-12-24 | 2020-12-23 | 転写増強関連ドメイン（ｔｅａｄ）転写因子インヒビターおよびそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230192607A1 (https=) |
| EP (1) | EP4081202A4 (https=) |
| JP (1) | JP7671293B2 (https=) |
| KR (1) | KR20220119671A (https=) |
| CN (1) | CN115103670A (https=) |
| AU (1) | AU2020415446A1 (https=) |
| BR (1) | BR112022012471A2 (https=) |
| CA (1) | CA3162348A1 (https=) |
| IL (1) | IL293735A (https=) |
| MX (1) | MX2022007951A (https=) |
| WO (1) | WO2021133896A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3205726A1 (en) * | 2021-01-25 | 2022-07-28 | Alfredo C. Castro | Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer |
| KR20240055778A (ko) | 2021-09-01 | 2024-04-29 | 노파르티스 아게 | Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도 |
| WO2023180385A1 (en) * | 2022-03-23 | 2023-09-28 | Sanofi | Transcriptional regulators of the tead family |
| CN119968359A (zh) | 2022-09-29 | 2025-05-09 | 英矽智能科技知识产权有限公司 | Tead抑制剂及其使用方法 |
| WO2024120519A1 (zh) * | 2022-12-09 | 2024-06-13 | 捷思英达控股有限公司 | Tead抑制剂、其制备方法和在医学上的应用 |
| CN116287270B (zh) * | 2023-03-17 | 2025-08-29 | 复旦大学附属中山医院 | Klf11在检测肺腺癌铁死亡和化疗敏感性中的应用 |
| TW202505036A (zh) * | 2023-03-31 | 2025-02-01 | 法商賽諾菲公司 | 作為tead活性癌症之標誌之基因轉錄本 |
| WO2024255856A1 (zh) * | 2023-06-14 | 2024-12-19 | 赛诺哈勃药业（成都）有限公司 | 一种调控tead活性的化合物、其制备方法及其用途 |
| CN116535379B (zh) * | 2023-06-29 | 2023-09-19 | 希格生科（深圳）有限公司 | 化合物及其医药用途 |
| CN117487816B (zh) * | 2023-11-03 | 2024-06-04 | 中山大学孙逸仙纪念医院 | Znf709基因在制备治疗pbc的药物中的应用 |
| CN117625791B (zh) * | 2024-01-23 | 2024-04-16 | 杭州华得森生物技术有限公司 | 用于结直肠癌诊断和预后判断的生物标志物及其应用 |
| CN118584109B (zh) * | 2024-03-26 | 2025-08-15 | 首都医科大学附属北京胸科医院 | 一种筛选耐药性肺癌的生物标志物 |
| WO2025238550A1 (en) * | 2024-05-14 | 2025-11-20 | Dana-Farber Cancer Institute, Inc. | Creatine kinase inhibitors |
| CN120624647B (zh) * | 2025-05-30 | 2026-04-03 | 山西省肿瘤医院 | 鼻咽癌诊断或预测的甲基化标志物组合及应用、试剂盒和计算机可读存储介质 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0848703T3 (da) * | 1995-07-21 | 2001-01-02 | Nycomed Austria Gmbh | Derivater af benzosulfonamider som inhibitorer for enzymet cyclooxygenase II |
| BRPI1012681B1 (pt) * | 2009-06-26 | 2019-03-26 | China Petroleum & Chemical Corporation | Composição de diesel e método de aumentar a estabilidade de oxidação de biodiesel |
| US9382239B2 (en) * | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
| WO2017053706A1 (en) * | 2015-09-23 | 2017-03-30 | The General Hospital Corporation | Tead transcription factor autopalmitoylation inhibitors |
| SG11201805286RA (en) * | 2015-12-24 | 2018-07-30 | Kyowa Hakko Kirin Co Ltd | α,β-UNSATURATED AMIDE COMPOUND |
| MX2019009200A (es) * | 2017-02-03 | 2019-10-21 | Univ California | Composiciones y métodos para inhibir el reticulón 4. |
| WO2018144869A1 (en) * | 2017-02-03 | 2018-08-09 | The Regents Of The University Of California | Compositons and methods for modulating uba5 |
| US11192865B2 (en) | 2017-08-21 | 2021-12-07 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| EP3866798A4 (en) * | 2018-10-15 | 2022-07-13 | Dana-Farber Cancer Institute, Inc. | ENHANCED TRANSCRIPTIONAL ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES |
| US20210403415A1 (en) * | 2018-10-26 | 2021-12-30 | The Trustees Of Indiana University | Compounds and methods to attenuate tumor progression and metastasis |
-
2020
- 2020-12-23 CA CA3162348A patent/CA3162348A1/en active Pending
- 2020-12-23 IL IL293735A patent/IL293735A/en unknown
- 2020-12-23 AU AU2020415446A patent/AU2020415446A1/en active Pending
- 2020-12-23 WO PCT/US2020/066811 patent/WO2021133896A1/en not_active Ceased
- 2020-12-23 KR KR1020227025225A patent/KR20220119671A/ko not_active Withdrawn
- 2020-12-23 US US17/789,023 patent/US20230192607A1/en active Pending
- 2020-12-23 CN CN202080096940.9A patent/CN115103670A/zh active Pending
- 2020-12-23 EP EP20904774.5A patent/EP4081202A4/en active Pending
- 2020-12-23 MX MX2022007951A patent/MX2022007951A/es unknown
- 2020-12-23 BR BR112022012471A patent/BR112022012471A2/pt not_active Application Discontinuation
- 2020-12-23 JP JP2022539129A patent/JP7671293B2/ja active Active
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