MX2019009200A - Composiciones y métodos para inhibir el reticulón 4. - Google Patents
Composiciones y métodos para inhibir el reticulón 4.Info
- Publication number
- MX2019009200A MX2019009200A MX2019009200A MX2019009200A MX2019009200A MX 2019009200 A MX2019009200 A MX 2019009200A MX 2019009200 A MX2019009200 A MX 2019009200A MX 2019009200 A MX2019009200 A MX 2019009200A MX 2019009200 A MX2019009200 A MX 2019009200A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- reticulon
- inhibiting
- inhibiting reticulon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen en la presente, entre otros, composiciones y métodos útiles para inhibir reticulón 4 (RTN4).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762454681P | 2017-02-03 | 2017-02-03 | |
US201762471865P | 2017-03-15 | 2017-03-15 | |
PCT/US2018/016650 WO2018144870A1 (en) | 2017-02-03 | 2018-02-02 | Compositions and methods for inhibiting reticulon 4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019009200A true MX2019009200A (es) | 2019-10-21 |
Family
ID=63040209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009200A MX2019009200A (es) | 2017-02-03 | 2018-02-02 | Composiciones y métodos para inhibir el reticulón 4. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20200062696A1 (es) |
EP (1) | EP3576728A4 (es) |
JP (1) | JP2020506935A (es) |
KR (1) | KR20190126074A (es) |
CN (1) | CN110461322A (es) |
AU (1) | AU2018215447A1 (es) |
BR (1) | BR112019016132A2 (es) |
CA (1) | CA3051587A1 (es) |
MX (1) | MX2019009200A (es) |
SG (1) | SG11201906671SA (es) |
WO (1) | WO2018144870A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020039094A1 (en) * | 2018-08-24 | 2020-02-27 | Xeniopro GmbH | Phenoxy(hetero)aryl ethers of antiproliferative activity |
IL293735A (en) * | 2019-12-24 | 2022-08-01 | Dana Farber Cancer Inst Inc | Inhibitors of transcription factor enhanced transcription partner region and their uses |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL102790A (en) * | 1991-09-17 | 1996-01-31 | Roussel Uclaf | History of 3-cycloalkyl-prop-2-anamide |
US5922775A (en) * | 1997-10-23 | 1999-07-13 | Octamer, Inc. | Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity |
US7928127B2 (en) * | 2005-05-19 | 2011-04-19 | Notre Dame University | Inhibitors of matrix metallaproteinases |
US8828390B2 (en) * | 2010-07-09 | 2014-09-09 | Universitat Zurich | Uses of NOGO-A inhibitors and related methods |
WO2012164103A2 (en) * | 2011-06-03 | 2012-12-06 | Universität Zürich | Blockers of the nogo-a s1pr pathway for the treatment of diseases characterized by neuronal damage and lack of subsequent repair |
TWI507191B (zh) * | 2011-08-03 | 2015-11-11 | 國立陽明大學 | 含src同源區2蛋白酪胺酸磷酸酶-1增效劑及其治療方法 |
CN104203242B (zh) * | 2012-04-04 | 2017-03-15 | 杭州德润玉成生物科技有限公司 | 取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂 |
US10782295B2 (en) * | 2013-08-13 | 2020-09-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
JP6513076B2 (ja) * | 2014-02-28 | 2019-05-15 | 国立大学法人東北大学 | アミド誘導体 |
CN106414397B (zh) * | 2014-04-16 | 2019-02-12 | 南洋理工大学 | 用于肽和蛋白质中半胱氨酸的选择性修饰的作为正交手柄的丙二烯酰胺 |
WO2016118951A2 (en) * | 2015-01-23 | 2016-07-28 | Confluence Life Sciences, Inc. | Heterocyclic itk inhibitors for treating inflammation and cancer |
CA3001847A1 (en) * | 2015-10-22 | 2017-04-27 | The Scripps Research Institute | Cysteine reactive probes and uses thereof |
-
2018
- 2018-02-02 US US16/482,947 patent/US20200062696A1/en not_active Abandoned
- 2018-02-02 CA CA3051587A patent/CA3051587A1/en not_active Abandoned
- 2018-02-02 EP EP18747169.3A patent/EP3576728A4/en not_active Withdrawn
- 2018-02-02 KR KR1020197025643A patent/KR20190126074A/ko unknown
- 2018-02-02 MX MX2019009200A patent/MX2019009200A/es unknown
- 2018-02-02 SG SG11201906671SA patent/SG11201906671SA/en unknown
- 2018-02-02 BR BR112019016132A patent/BR112019016132A2/pt not_active Application Discontinuation
- 2018-02-02 CN CN201880020332.2A patent/CN110461322A/zh active Pending
- 2018-02-02 AU AU2018215447A patent/AU2018215447A1/en not_active Abandoned
- 2018-02-02 JP JP2019542113A patent/JP2020506935A/ja active Pending
- 2018-02-02 WO PCT/US2018/016650 patent/WO2018144870A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3576728A4 (en) | 2020-08-12 |
WO2018144870A8 (en) | 2019-09-06 |
CN110461322A (zh) | 2019-11-15 |
WO2018144870A1 (en) | 2018-08-09 |
AU2018215447A1 (en) | 2019-08-08 |
KR20190126074A (ko) | 2019-11-08 |
EP3576728A1 (en) | 2019-12-11 |
SG11201906671SA (en) | 2019-08-27 |
JP2020506935A (ja) | 2020-03-05 |
CA3051587A1 (en) | 2018-08-09 |
US20200062696A1 (en) | 2020-02-27 |
BR112019016132A2 (pt) | 2020-04-07 |
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