CN115103670A - 转录增强相关结构域(tead)转录因子抑制剂及其用途 - Google Patents
转录增强相关结构域(tead)转录因子抑制剂及其用途 Download PDFInfo
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- CN115103670A CN115103670A CN202080096940.9A CN202080096940A CN115103670A CN 115103670 A CN115103670 A CN 115103670A CN 202080096940 A CN202080096940 A CN 202080096940A CN 115103670 A CN115103670 A CN 115103670A
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962953381P | 2019-12-24 | 2019-12-24 | |
| US62/953,381 | 2019-12-24 | ||
| PCT/US2020/066811 WO2021133896A1 (en) | 2019-12-24 | 2020-12-23 | Transcriptional enhanced associate doman (tead) transcription factor inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115103670A true CN115103670A (zh) | 2022-09-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080096940.9A Pending CN115103670A (zh) | 2019-12-24 | 2020-12-23 | 转录增强相关结构域(tead)转录因子抑制剂及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230192607A1 (https=) |
| EP (1) | EP4081202A4 (https=) |
| JP (1) | JP7671293B2 (https=) |
| KR (1) | KR20220119671A (https=) |
| CN (1) | CN115103670A (https=) |
| AU (1) | AU2020415446A1 (https=) |
| BR (1) | BR112022012471A2 (https=) |
| CA (1) | CA3162348A1 (https=) |
| IL (1) | IL293735A (https=) |
| MX (1) | MX2022007951A (https=) |
| WO (1) | WO2021133896A1 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116287270A (zh) * | 2023-03-17 | 2023-06-23 | 复旦大学附属中山医院 | Klf11在检测肺腺癌铁死亡和化疗敏感性中的应用 |
| CN116535379A (zh) * | 2023-06-29 | 2023-08-04 | 希格生科(深圳)有限公司 | 化合物及其医药用途 |
| CN117487816A (zh) * | 2023-11-03 | 2024-02-02 | 中山大学孙逸仙纪念医院 | Znf709基因在制备治疗pbc的药物中的应用 |
| CN117625791A (zh) * | 2024-01-23 | 2024-03-01 | 杭州华得森生物技术有限公司 | 用于结直肠癌诊断和预后判断的生物标志物及其应用 |
| WO2024120519A1 (zh) * | 2022-12-09 | 2024-06-13 | 捷思英达控股有限公司 | Tead抑制剂、其制备方法和在医学上的应用 |
| CN118584109A (zh) * | 2024-03-26 | 2024-09-03 | 首都医科大学附属北京胸科医院 | 一种筛选耐药性肺癌的生物标志物 |
| WO2024255856A1 (zh) * | 2023-06-14 | 2024-12-19 | 赛诺哈勃药业(成都)有限公司 | 一种调控tead活性的化合物、其制备方法及其用途 |
| CN120624647A (zh) * | 2025-05-30 | 2025-09-12 | 山西省肿瘤医院 | 鼻咽癌诊断或预测的甲基化标志物组合及应用、试剂盒和计算机可读存储介质 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3205726A1 (en) * | 2021-01-25 | 2022-07-28 | Alfredo C. Castro | Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer |
| KR20240055778A (ko) | 2021-09-01 | 2024-04-29 | 노파르티스 아게 | Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도 |
| WO2023180385A1 (en) * | 2022-03-23 | 2023-09-28 | Sanofi | Transcriptional regulators of the tead family |
| CN119968359A (zh) | 2022-09-29 | 2025-05-09 | 英矽智能科技知识产权有限公司 | Tead抑制剂及其使用方法 |
| TW202505036A (zh) * | 2023-03-31 | 2025-02-01 | 法商賽諾菲公司 | 作為tead活性癌症之標誌之基因轉錄本 |
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Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0848703T3 (da) * | 1995-07-21 | 2001-01-02 | Nycomed Austria Gmbh | Derivater af benzosulfonamider som inhibitorer for enzymet cyclooxygenase II |
| BRPI1012681B1 (pt) * | 2009-06-26 | 2019-03-26 | China Petroleum & Chemical Corporation | Composição de diesel e método de aumentar a estabilidade de oxidação de biodiesel |
| US9382239B2 (en) * | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
| WO2017053706A1 (en) * | 2015-09-23 | 2017-03-30 | The General Hospital Corporation | Tead transcription factor autopalmitoylation inhibitors |
| SG11201805286RA (en) * | 2015-12-24 | 2018-07-30 | Kyowa Hakko Kirin Co Ltd | α,β-UNSATURATED AMIDE COMPOUND |
| MX2019009200A (es) * | 2017-02-03 | 2019-10-21 | Univ California | Composiciones y métodos para inhibir el reticulón 4. |
| WO2018144869A1 (en) * | 2017-02-03 | 2018-08-09 | The Regents Of The University Of California | Compositons and methods for modulating uba5 |
| US11192865B2 (en) | 2017-08-21 | 2021-12-07 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| EP3866798A4 (en) * | 2018-10-15 | 2022-07-13 | Dana-Farber Cancer Institute, Inc. | ENHANCED TRANSCRIPTIONAL ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES |
| US20210403415A1 (en) * | 2018-10-26 | 2021-12-30 | The Trustees Of Indiana University | Compounds and methods to attenuate tumor progression and metastasis |
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- 2020-12-23 IL IL293735A patent/IL293735A/en unknown
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- 2020-12-23 BR BR112022012471A patent/BR112022012471A2/pt not_active Application Discontinuation
- 2020-12-23 JP JP2022539129A patent/JP7671293B2/ja active Active
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| WO2024120519A1 (zh) * | 2022-12-09 | 2024-06-13 | 捷思英达控股有限公司 | Tead抑制剂、其制备方法和在医学上的应用 |
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| WO2024255856A1 (zh) * | 2023-06-14 | 2024-12-19 | 赛诺哈勃药业(成都)有限公司 | 一种调控tead活性的化合物、其制备方法及其用途 |
| CN116535379A (zh) * | 2023-06-29 | 2023-08-04 | 希格生科(深圳)有限公司 | 化合物及其医药用途 |
| CN116535379B (zh) * | 2023-06-29 | 2023-09-19 | 希格生科(深圳)有限公司 | 化合物及其医药用途 |
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| CN118584109A (zh) * | 2024-03-26 | 2024-09-03 | 首都医科大学附属北京胸科医院 | 一种筛选耐药性肺癌的生物标志物 |
| CN120624647A (zh) * | 2025-05-30 | 2025-09-12 | 山西省肿瘤医院 | 鼻咽癌诊断或预测的甲基化标志物组合及应用、试剂盒和计算机可读存储介质 |
| CN120624647B (zh) * | 2025-05-30 | 2026-04-03 | 山西省肿瘤医院 | 鼻咽癌诊断或预测的甲基化标志物组合及应用、试剂盒和计算机可读存储介质 |
Also Published As
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| WO2021133896A1 (en) | 2021-07-01 |
| AU2020415446A1 (en) | 2022-07-14 |
| BR112022012471A2 (pt) | 2022-11-29 |
| CA3162348A1 (en) | 2021-07-01 |
| MX2022007951A (es) | 2022-09-29 |
| KR20220119671A (ko) | 2022-08-30 |
| EP4081202A1 (en) | 2022-11-02 |
| IL293735A (en) | 2022-08-01 |
| US20230192607A1 (en) | 2023-06-22 |
| WO2021133896A8 (en) | 2022-06-09 |
| JP2023508982A (ja) | 2023-03-06 |
| JP7671293B2 (ja) | 2025-05-01 |
| EP4081202A4 (en) | 2024-02-21 |
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