JP2023507034A5 - - Google Patents

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Publication number
JP2023507034A5
JP2023507034A5 JP2022538379A JP2022538379A JP2023507034A5 JP 2023507034 A5 JP2023507034 A5 JP 2023507034A5 JP 2022538379 A JP2022538379 A JP 2022538379A JP 2022538379 A JP2022538379 A JP 2022538379A JP 2023507034 A5 JP2023507034 A5 JP 2023507034A5
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JP
Japan
Prior art keywords
fusion protein
sequence
cells
gene
sgrna
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JP2022538379A
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English (en)
Japanese (ja)
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JP7606176B2 (ja
JP2023507034A (ja
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Priority claimed from CN201911310969.8A external-priority patent/CN112979821B/zh
Priority claimed from CN201911312544.0A external-priority patent/CN112979823B/zh
Priority claimed from CN201911312537.0A external-priority patent/CN112979822B/zh
Application filed filed Critical
Priority claimed from PCT/CN2020/137239 external-priority patent/WO2021121321A1/zh
Publication of JP2023507034A publication Critical patent/JP2023507034A/ja
Publication of JP2023507034A5 publication Critical patent/JP2023507034A5/ja
Application granted granted Critical
Publication of JP7606176B2 publication Critical patent/JP7606176B2/ja
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JP2022538379A 2019-12-18 2020-12-17 ゲノム編集効率を向上させる融合タンパク質及びその使用 Active JP7606176B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201911310969.8 2019-12-18
CN201911310969.8A CN112979821B (zh) 2019-12-18 2019-12-18 一种提高基因编辑效率的融合蛋白及其应用
CN201911312544.0A CN112979823B (zh) 2019-12-18 2019-12-18 一种用于治疗和/或预防β血红蛋白病的产品及融合蛋白
CN201911312537.0 2019-12-18
CN201911312544.0 2019-12-18
CN201911312537.0A CN112979822B (zh) 2019-12-18 2019-12-18 一种疾病动物模型的构建方法及融合蛋白
PCT/CN2020/137239 WO2021121321A1 (zh) 2019-12-18 2020-12-17 一种提高基因编辑效率的融合蛋白及其应用

Publications (3)

Publication Number Publication Date
JP2023507034A JP2023507034A (ja) 2023-02-20
JP2023507034A5 true JP2023507034A5 (https=) 2024-03-26
JP7606176B2 JP7606176B2 (ja) 2024-12-25

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ID=76477098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022538379A Active JP7606176B2 (ja) 2019-12-18 2020-12-17 ゲノム編集効率を向上させる融合タンパク質及びその使用

Country Status (4)

Country Link
US (1) US20220364072A1 (https=)
EP (1) EP4079765A4 (https=)
JP (1) JP7606176B2 (https=)
WO (1) WO2021121321A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102616916B1 (ko) * 2021-05-11 2023-12-21 주식회사 애이마 발암성 돌연변이 유전자 검출용 가이드 rna 내지 이의 용도
CN113621634B (zh) * 2021-07-07 2023-09-15 浙江大学杭州国际科创中心 一种增加基因组突变率的碱基编辑系统及碱基编辑方法
JP7125727B1 (ja) * 2021-09-07 2022-08-25 国立大学法人千葉大学 核酸配列改変用組成物および核酸配列の標的部位を改変する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010132092A2 (en) * 2009-05-12 2010-11-18 The Scripps Research Institute Cytidine deaminase fusions and related methods
ITFI20120173A1 (it) * 2012-08-30 2014-03-01 Selex Galileo Spa "sistema di visione con telecamera e sistema di limitazione delle sollecitazioni"
US20150165054A1 (en) * 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
JP6799586B2 (ja) * 2015-08-28 2020-12-16 ザ ジェネラル ホスピタル コーポレイション 遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
CN105647968B (zh) * 2016-02-02 2019-07-23 浙江大学 一种CRISPR/Cas9工作效率快速测试系统及其应用
WO2017142923A1 (en) * 2016-02-16 2017-08-24 Emendobio Inc. Compositions and methods for promoting homology directed repair mediated gene editing
KR20240116572A (ko) * 2017-03-23 2024-07-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
EP3622070A2 (en) * 2017-05-10 2020-03-18 Editas Medicine, Inc. Crispr/rna-guided nuclease systems and methods
CN108588182B (zh) * 2018-04-13 2025-11-28 武汉中科先进技术研究院有限公司 基于crispr-链取代的等温扩增及检测技术
CN108707635B (zh) * 2018-05-29 2022-02-15 华东师范大学 用于核苷酸序列修饰的组合物、方法与应用
CN109880851B (zh) * 2019-03-28 2020-12-01 西北农林科技大学 用于富集CRISPR/Cas9介导的同源重组修复细胞的筛选报告载体及筛选方法

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