JP2023504172A5 - - Google Patents
Info
- Publication number
- JP2023504172A5 JP2023504172A5 JP2022532773A JP2022532773A JP2023504172A5 JP 2023504172 A5 JP2023504172 A5 JP 2023504172A5 JP 2022532773 A JP2022532773 A JP 2022532773A JP 2022532773 A JP2022532773 A JP 2022532773A JP 2023504172 A5 JP2023504172 A5 JP 2023504172A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc class
- chain
- molecule
- mhc
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025132396A JP2025159063A (ja) | 2019-12-02 | 2025-08-07 | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962942344P | 2019-12-02 | 2019-12-02 | |
| US62/942,344 | 2019-12-02 | ||
| PCT/US2020/062801 WO2021113297A1 (en) | 2019-12-02 | 2020-12-02 | Peptide-mhc ii protein constructs and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025132396A Division JP2025159063A (ja) | 2019-12-02 | 2025-08-07 | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504172A JP2023504172A (ja) | 2023-02-01 |
| JP2023504172A5 true JP2023504172A5 (https=) | 2023-11-29 |
| JP7726881B2 JP7726881B2 (ja) | 2025-08-20 |
Family
ID=74046157
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022532773A Active JP7726881B2 (ja) | 2019-12-02 | 2020-12-02 | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
| JP2025132396A Pending JP2025159063A (ja) | 2019-12-02 | 2025-08-07 | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025132396A Pending JP2025159063A (ja) | 2019-12-02 | 2025-08-07 | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220409732A1 (https=) |
| EP (1) | EP4069722A1 (https=) |
| JP (2) | JP7726881B2 (https=) |
| KR (1) | KR20220110233A (https=) |
| CN (1) | CN114901678A (https=) |
| AU (1) | AU2020395122A1 (https=) |
| CA (1) | CA3163549A1 (https=) |
| IL (1) | IL293330A (https=) |
| WO (1) | WO2021113297A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2973548T3 (es) | 2016-12-22 | 2024-06-20 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso |
| US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| JP2026507123A (ja) | 2023-02-28 | 2026-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｔ細胞活性化剤およびその使用方法 |
| CN118813436A (zh) * | 2023-07-24 | 2024-10-22 | 佳吾益(北京)科技有限公司 | 展示单mhc等位基因功能蛋白的工程化细胞 |
| WO2025064770A2 (en) * | 2023-09-20 | 2025-03-27 | La Jolla Institute of Immunology | Alphavirus t cell epitopes, megapools and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025064029A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibody molecules binding to a peptide-mhc interface |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2026006724A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Prame off-target peptides and uses thereof |
| WO2026006734A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Off-target peptide-mhc complex conformation modeling systems and methods for antigen-recognition molecule development |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US6413935B1 (en) | 1993-09-14 | 2002-07-02 | Epimmune Inc. | Induction of immune response against desired determinants |
| DE69435171D1 (de) | 1993-09-14 | 2009-01-08 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2002076196A1 (en) | 2001-03-22 | 2002-10-03 | Abbott Gmbh & Co. Kg | Transgenic animals expressing antibodies specific for genes of interest and uses thereof |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| AU2007235496B2 (en) | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| PL2602323T3 (pl) | 2007-06-01 | 2018-06-29 | Open Monoclonal Technology, Inc. | Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego |
| EP2147594B1 (en) | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| AU2009298458B2 (en) | 2008-09-30 | 2015-10-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| WO2010037397A1 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| ES2724975T3 (es) | 2009-12-10 | 2019-09-18 | Regeneron Pharma | Ratones que producen anticuerpos de cadena pesada |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| GB201002730D0 (en) * | 2010-02-18 | 2010-04-07 | Uni I Oslo | Product |
| ES2984483T3 (es) | 2010-03-31 | 2024-10-29 | Ablexis Llc | Ingeniería genética de ratones para la producción de anticuerpos quiméricos |
| WO2011147894A1 (en) * | 2010-05-25 | 2011-12-01 | Forschungsverbund Berlin E.V. | Chimeric mhc class ii proteinpeptide |
| PT3034608T (pt) | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| JP2012120488A (ja) | 2010-12-09 | 2012-06-28 | Univ Of Tokyo | 新規安定化組換えｍｈｃタンパク質 |
| ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
| HUE047278T2 (hu) | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| SG11201401181YA (en) | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SMT202200205T1 (it) | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| CN107858333B (zh) | 2011-10-28 | 2022-05-27 | 瑞泽恩制药公司 | T细胞受体基因修饰小鼠 |
| JP6364352B2 (ja) | 2012-01-06 | 2018-07-25 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 部分的ｍｈｃコンストラクト及びその使用方法 |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| PT2931030T (pt) | 2012-12-14 | 2020-08-03 | Open Monoclonal Tech Inc | Polinucleótidos que codificam anticorpos de roedores com idiótipos humanos e animais que os compreendem |
| US9475559B2 (en) | 2013-07-03 | 2016-10-25 | Hobie Cat Company | Foot operated propulsion system for watercraft |
| US9410301B2 (en) | 2014-12-09 | 2016-08-09 | Theophile Bourgeois | Patch system and method for oil boom |
| CN113831407B (zh) | 2016-05-20 | 2024-06-11 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| US20180127481A1 (en) | 2016-11-09 | 2018-05-10 | Uti Limited Partnership | RECOMBINANT pMHC CLASS II MOLECULES |
| WO2019051126A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | ANTIGEN PRESENTING POLYPEPTIDES COMPRISING CHEMICAL CONJUGATION SITES AND METHODS OF USE THEREOF |
| CN117777294A (zh) * | 2017-10-03 | 2024-03-29 | 中外制药株式会社 | 抗hla-dq2.5抗体 |
| RU2763798C1 (ru) * | 2017-12-23 | 2022-01-11 | Рубиус Терапьютикс, Инк. | Искусственные антигенпрезентирующие клетки и способы их применения |
| EP3772927B1 (en) | 2018-03-24 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
-
2020
- 2020-12-02 US US17/780,158 patent/US20220409732A1/en active Pending
- 2020-12-02 EP EP20829434.8A patent/EP4069722A1/en active Pending
- 2020-12-02 WO PCT/US2020/062801 patent/WO2021113297A1/en not_active Ceased
- 2020-12-02 CN CN202080090908.XA patent/CN114901678A/zh active Pending
- 2020-12-02 JP JP2022532773A patent/JP7726881B2/ja active Active
- 2020-12-02 CA CA3163549A patent/CA3163549A1/en active Pending
- 2020-12-02 IL IL293330A patent/IL293330A/en unknown
- 2020-12-02 KR KR1020227021577A patent/KR20220110233A/ko active Pending
- 2020-12-02 AU AU2020395122A patent/AU2020395122A1/en active Pending
-
2025
- 2025-08-07 JP JP2025132396A patent/JP2025159063A/ja active Pending
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