JP2024546875A5 - - Google Patents

Info

Publication number
JP2024546875A5
JP2024546875A5 JP2024535534A JP2024535534A JP2024546875A5 JP 2024546875 A5 JP2024546875 A5 JP 2024546875A5 JP 2024535534 A JP2024535534 A JP 2024535534A JP 2024535534 A JP2024535534 A JP 2024535534A JP 2024546875 A5 JP2024546875 A5 JP 2024546875A5
Authority
JP
Japan
Prior art keywords
pmhc
binding
domain
antigen
binding protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024535534A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024546875A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2022/085689 external-priority patent/WO2023110918A1/en
Publication of JP2024546875A publication Critical patent/JP2024546875A/ja
Publication of JP2024546875A5 publication Critical patent/JP2024546875A5/ja
Pending legal-status Critical Current

Links

JP2024535534A 2021-12-14 2022-12-13 二連型mhc標的化t細胞エンゲージャー Pending JP2024546875A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163289380P 2021-12-14 2021-12-14
US63/289,380 2021-12-14
US202263317256P 2022-03-07 2022-03-07
US63/317,256 2022-03-07
US202263328417P 2022-04-07 2022-04-07
US63/328,417 2022-04-07
PCT/EP2022/085689 WO2023110918A1 (en) 2021-12-14 2022-12-13 Dual mhc-targeting t cell engager

Publications (2)

Publication Number Publication Date
JP2024546875A JP2024546875A (ja) 2024-12-26
JP2024546875A5 true JP2024546875A5 (https=) 2025-12-23

Family

ID=84887466

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024535534A Pending JP2024546875A (ja) 2021-12-14 2022-12-13 二連型mhc標的化t細胞エンゲージャー

Country Status (8)

Country Link
US (1) US20250002586A1 (https=)
EP (1) EP4448570A1 (https=)
JP (1) JP2024546875A (https=)
KR (1) KR20240116828A (https=)
AU (1) AU2022413444A1 (https=)
CA (1) CA3240046A1 (https=)
MX (1) MX2024007473A (https=)
WO (1) WO2023110918A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025210181A1 (en) * 2024-04-04 2025-10-09 Cdr-Life Ag Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750325B1 (en) 1989-12-21 2004-06-15 Celltech R&D Limited CD3 specific recombinant antibody
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US7381803B1 (en) 1992-03-27 2008-06-03 Pdl Biopharma, Inc. Humanized antibodies against CD3
GB9524973D0 (en) 1995-12-06 1996-02-07 Lynxvale Ltd Viral vectors
US7112324B1 (en) 1998-04-21 2006-09-26 Micromet Ag CD 19×CD3 specific polypeptides and uses thereof
WO2004016740A2 (en) 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
JP3803790B2 (ja) 2003-02-17 2006-08-02 株式会社東北テクノアーチ 新規なダイアボディ型二重特異性抗体
AU2003259718A1 (en) 2003-08-07 2005-03-07 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
MXPA06004035A (es) 2003-10-16 2006-08-31 Micromet Ag Aglutinantes cd3 de-inmunizados multi-especificos.
CA2569509C (en) 2004-06-03 2014-08-12 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
JP4902674B2 (ja) 2006-03-09 2012-03-21 エフ.ホフマン−ラ ロシュ アーゲー 抗薬物抗体アッセイ法
CA2673470A1 (en) 2006-12-21 2008-07-03 Macrogenics, Inc. Methods for the treatment of lada and other adult-onset autoimmune diabetes using immunosuppressive monoclonal antibodies with reduced toxicity
RU2009137582A (ru) 2007-03-12 2011-04-20 Эсбатек Аг (Ch) Инженерия и оптимизация одноцепочечных антител на основе последовательности
RS53008B2 (sr) 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
KR20170036814A (ko) 2007-05-21 2017-04-03 앨더바이오 홀딩스 엘엘씨 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
BRPI0813645A2 (pt) 2007-06-25 2014-12-30 Esbatech Alcon Biomed Res Unit Métodos para modificar anticorpos, e anticorpos modificados com propriedades funcionais aperfeiçoadas
EP2164961B1 (en) 2007-06-25 2015-01-07 ESBATech, an Alcon Biomedical Research Unit LLC Sequence based engineering and optimization of single chain antibodies
CA2728829C (en) 2008-06-25 2018-01-02 Esbatech, An Alcon Biomedical Research Unit Llc Solubility optimization of immunobinders
PL2307458T3 (pl) 2008-06-25 2018-08-31 Esbatech, An Alcon Biomedical Research Unit Llc Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała
KR102211837B1 (ko) 2013-01-14 2021-02-03 젠코어 인코포레이티드 신규한 이형이량체 단백질
JP6594855B2 (ja) 2013-03-15 2019-10-23 ゼンコア インコーポレイテッド ヘテロ二量体タンパク質
IL263466B2 (en) 2013-12-17 2023-10-01 Genentech Inc Anti-CD3 antibodies and methods of using them
WO2015123315A1 (en) 2014-02-11 2015-08-20 Genzyme Corporation Assays for detecting the presence or amount of an anti-drug antibody
PE20171324A1 (es) 2014-11-26 2017-09-11 Xencor Inc Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales
US12480957B2 (en) 2017-03-31 2025-11-25 Ablynx N.V. Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs
LT3428194T (lt) * 2017-07-14 2021-12-10 Immatics Biotechnologies Gmbh Pagerinta dvejopo savitumo polipeptido molekulė
WO2019195535A1 (en) 2018-04-05 2019-10-10 Novartis Ag Trispecific binding molecules against cancers and uses thereof
KR20220015382A (ko) * 2019-05-29 2022-02-08 큐 바이오파마, 인크. 다량체 t-세포 조절 폴리펩타이드 및 이의 사용 방법
EP4025908A4 (en) 2019-09-05 2023-07-19 Adverum Biotechnologies, Inc. ANTI-DRUG ANTIBODY TEST
NL2024375B1 (en) * 2019-12-04 2021-08-31 Apo T B V Methods and means for attracting immune effector cells to tumor cells.
IL293698A (en) * 2019-12-11 2022-08-01 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins, their production and use
MX2023010541A (es) 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same

Similar Documents

Publication Publication Date Title
JP2020186248A5 (https=)
US20170210818A1 (en) Constant region antibody fusion proteins and compositions thereof
JP2023504914A5 (https=)
JP2020506898A5 (https=)
JP2024532485A5 (https=)
JP2001521496A (ja) 高い結合活性の多価および多特異的試薬
CN117285642A (zh) 制导和导航控制蛋白及其制备和使用方法
JP2020500510A5 (https=)
WO2020186974A1 (zh) 一种双特异性抗体及其制备方法与应用
EP3472205A1 (en) Chimeric antigen receptor
CN119032104A (zh) 抗血清白蛋白纳米抗体及其衍生物
CA3173414A1 (en) Pd-1 agonist multimeric binding molecules
JP2024507540A5 (https=)
WO2017200796A1 (en) Engineered pd-1 variants
JP2024509910A5 (https=)
JP2024547218A5 (https=)
JP2024507693A (ja) 二重特異性抗体
JP2024507693A5 (https=)
JP2023544211A5 (https=)
JP2016529213A5 (https=)
JP2024546875A5 (https=)
CN116888259A (zh) 抗c4d嵌合抗原受体调节性t细胞及其用途
CN113614103A (zh) 不直接向其附着的细胞传导信号的非天然nkg2d受体
JP2021524451A5 (https=)
CN111201242A (zh) 不对称异二聚fc-scfv融合抗globo h及抗cd3双特异性抗体及其在癌症治疗上的用途