JP2023502335A5 - - Google Patents
Info
- Publication number
- JP2023502335A5 JP2023502335A5 JP2022526270A JP2022526270A JP2023502335A5 JP 2023502335 A5 JP2023502335 A5 JP 2023502335A5 JP 2022526270 A JP2022526270 A JP 2022526270A JP 2022526270 A JP2022526270 A JP 2022526270A JP 2023502335 A5 JP2023502335 A5 JP 2023502335A5
- Authority
- JP
- Japan
- Prior art keywords
- intane
- ranked
- variant
- solid phase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025101380A JP2025133756A (ja) | 2019-11-22 | 2025-06-17 | スプリットインテインシステムを使用したタンパク質精製 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1917046.3 | 2019-11-22 | ||
| GBGB1917046.3A GB201917046D0 (en) | 2019-11-22 | 2019-11-22 | Improved protein production |
| PCT/EP2020/082966 WO2021099607A1 (en) | 2019-11-22 | 2020-11-20 | Protein purification using a split intein system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025101380A Division JP2025133756A (ja) | 2019-11-22 | 2025-06-17 | スプリットインテインシステムを使用したタンパク質精製 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023502335A JP2023502335A (ja) | 2023-01-24 |
| JP2023502335A5 true JP2023502335A5 (https=) | 2023-11-30 |
| JP7744026B2 JP7744026B2 (ja) | 2025-09-25 |
Family
ID=69137378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022526270A Active JP7744026B2 (ja) | 2019-11-22 | 2020-11-20 | スプリットインテインシステムを使用したタンパク質精製 |
| JP2025101380A Pending JP2025133756A (ja) | 2019-11-22 | 2025-06-17 | スプリットインテインシステムを使用したタンパク質精製 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025101380A Pending JP2025133756A (ja) | 2019-11-22 | 2025-06-17 | スプリットインテインシステムを使用したタンパク質精製 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240132538A1 (https=) |
| EP (1) | EP4061932A1 (https=) |
| JP (2) | JP7744026B2 (https=) |
| KR (1) | KR20220105157A (https=) |
| CN (2) | CN114698379B (https=) |
| CA (1) | CA3155170A1 (https=) |
| GB (1) | GB201917046D0 (https=) |
| WO (1) | WO2021099607A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4126899A1 (en) * | 2020-03-25 | 2023-02-08 | Merck Patent GmbH | Reuse of intein-bound resins for protein purification |
| KR20240007210A (ko) | 2021-05-12 | 2024-01-16 | 씨티바 바이오프로세스 알＆디 에이비 | 개선된 단백질 정제 |
| CN114606252A (zh) * | 2022-04-20 | 2022-06-10 | 广州市乾相生物科技有限公司 | 一种基于过滤法的寡肽合成及纯化方法 |
| CN115028741A (zh) * | 2022-06-21 | 2022-09-09 | 苏州工业园区唯可达生物科技有限公司 | 一种肿瘤抗原抗体复合物及制备方法和应用 |
| CN115925830B (zh) * | 2022-08-15 | 2023-11-07 | 广州市乾相生物科技有限公司 | 一种内含肽变体及其在生物法制备类蛇毒肽前体中的应用 |
| AU2024270243A1 (en) | 2023-05-08 | 2025-11-06 | Cytiva Bioprocess R&D Ab | Split inteins for affinity capture |
| EP4726045A1 (en) | 2023-06-07 | 2026-04-15 | Peking University Third Hospital (The Third Clinical Medical School of Peking University) | Expression cassette combination and use thereof |
| EP4724477A1 (en) | 2023-06-11 | 2026-04-15 | Regeneron Pharmaceuticals, Inc. | Circularized antibody molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102096534B1 (ko) * | 2011-09-28 | 2020-04-03 | 에라 바이오테크, 에스.에이. | 분할된 인테인 및 그의 이용 |
| EP3431497B1 (en) | 2012-06-27 | 2022-07-27 | The Trustees of Princeton University | Split inteins, conjugates and uses thereof |
| WO2014056199A1 (zh) * | 2012-10-12 | 2014-04-17 | 清华大学 | 多肽的产生和纯化方法 |
| US10087213B2 (en) | 2013-01-11 | 2018-10-02 | The Texas A&M University System | Intein mediated purification of protein |
| WO2015052460A1 (en) | 2013-10-09 | 2015-04-16 | Ucl Business Plc | Chromatography medium |
| PL3215614T3 (pl) | 2014-11-03 | 2019-12-31 | Merck Patent Gmbh | Rozpuszczalne białka fuzyjne inteiny i sposoby oczyszczania biocząsteczek |
| JP7204086B2 (ja) | 2014-12-17 | 2023-01-16 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 改変κ軽鎖結合ポリペプチド |
| US10066027B2 (en) | 2015-01-09 | 2018-09-04 | Ohio State Innovation Foundation | Protein production systems and methods thereof |
| CN105316353A (zh) * | 2015-02-13 | 2016-02-10 | 上海交通大学 | 一种利用碱性标签和内含肽融合表达纯化重组蛋白的方法 |
| PT3408292T (pt) | 2016-01-29 | 2023-07-19 | Univ Princeton | Inteínas divididas com excecional atividade de splicing |
| CN105925596A (zh) * | 2016-02-23 | 2016-09-07 | 上海交通大学 | 基于内含肽的药用重组蛋白的合成方法 |
| KR101857953B1 (ko) | 2016-07-06 | 2018-05-16 | 아미코젠주식회사 | 알칼리 내성이 증가된 변이 면역글로불린 결합 단백질 |
| US11124539B2 (en) | 2016-11-16 | 2021-09-21 | Cytiva Bioprocess R&D Ab | Chromatography resin, production and use thereof |
-
2019
- 2019-11-22 GB GBGB1917046.3A patent/GB201917046D0/en not_active Ceased
-
2020
- 2020-11-20 JP JP2022526270A patent/JP7744026B2/ja active Active
- 2020-11-20 WO PCT/EP2020/082966 patent/WO2021099607A1/en not_active Ceased
- 2020-11-20 US US17/768,461 patent/US20240132538A1/en active Pending
- 2020-11-20 KR KR1020227016527A patent/KR20220105157A/ko active Pending
- 2020-11-20 EP EP20820794.4A patent/EP4061932A1/en active Pending
- 2020-11-20 CA CA3155170A patent/CA3155170A1/en active Pending
- 2020-11-20 CN CN202080080416.2A patent/CN114698379B/zh active Active
- 2020-11-20 CN CN202510113276.9A patent/CN120249241A/zh active Pending
-
2025
- 2025-06-17 JP JP2025101380A patent/JP2025133756A/ja active Pending
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