JP2023126540A5 - - Google Patents
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- JP2023126540A5 JP2023126540A5 JP2023116961A JP2023116961A JP2023126540A5 JP 2023126540 A5 JP2023126540 A5 JP 2023126540A5 JP 2023116961 A JP2023116961 A JP 2023116961A JP 2023116961 A JP2023116961 A JP 2023116961A JP 2023126540 A5 JP2023126540 A5 JP 2023126540A5
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- JP
- Japan
- Prior art keywords
- endoxifen
- enteric coated
- oral formulation
- coated oral
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 748
- 238000000034 method Methods 0.000 claims description 245
- 150000001875 compounds Chemical class 0.000 claims description 233
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims description 190
- 238000009472 formulation Methods 0.000 claims description 190
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 111
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 99
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 94
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- 229960001603 tamoxifen Drugs 0.000 claims description 86
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- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 76
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 47
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- QOPVNWQGBQYBBP-UHFFFAOYSA-N chloroethyl chloroformate Chemical compound CC(Cl)OC(Cl)=O QOPVNWQGBQYBBP-UHFFFAOYSA-N 0.000 description 15
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2018
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