JP2023120393A5 - - Google Patents

Info

Publication number

JP2023120393A5

JP2023120393A5 JP2023103829A JP2023103829A JP2023120393A5 JP 2023120393 A5 JP2023120393 A5 JP 2023120393A5 JP 2023103829 A JP2023103829 A JP 2023103829A JP 2023103829 A JP2023103829 A JP 2023103829A JP 2023120393 A5 JP2023120393 A5 JP 2023120393A5

Authority

JP

Japan

Prior art keywords

composition

nanoparticles

taxane

cancer

silicone oils

Prior art date

2023-06-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 36
• 239000002105 nanoparticle Substances 0.000 claims 19
• 229940123237 Taxane Drugs 0.000 claims 15
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 15
• 229920002545 silicone oil Polymers 0.000 claims 8
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• 239000012051 hydrophobic carrier Substances 0.000 claims 3
• 239000004215 Carbon black (E152) Substances 0.000 claims 2
• XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 2
• 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229930195733 hydrocarbon Natural products 0.000 claims 2
• 150000002430 hydrocarbons Chemical class 0.000 claims 2
• 230000036210 malignancy Effects 0.000 claims 2
• 235000019271 petrolatum Nutrition 0.000 claims 2
• 201000000849 skin cancer Diseases 0.000 claims 2
• 239000008247 solid mixture Substances 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 206010027465 Metastases to skin Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 239000004264 Petrolatum Substances 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000003373 basosquamous carcinoma Diseases 0.000 claims 1
• 229960001573 cabazitaxel Drugs 0.000 claims 1
• BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 229940086555 cyclomethicone Drugs 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 230000002500 effect on skin Effects 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 239000012535 impurity Substances 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 239000002480 mineral oil Substances 0.000 claims 1
• 235000010446 mineral oil Nutrition 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 201000005443 oral cavity cancer Diseases 0.000 claims 1
• 239000012188 paraffin wax Substances 0.000 claims 1
• 235000019809 paraffin wax Nutrition 0.000 claims 1
• 229940066842 petrolatum Drugs 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1