JPWO2019178024A5 - - Google Patents

Info

Publication number

JPWO2019178024A5

JPWO2019178024A5 JP2020549671A JP2020549671A JPWO2019178024A5 JP WO2019178024 A5 JPWO2019178024 A5 JP WO2019178024A5 JP 2020549671 A JP2020549671 A JP 2020549671A JP 2020549671 A JP2020549671 A JP 2020549671A JP WO2019178024 A5 JPWO2019178024 A5 JP WO2019178024A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

nanoparticles

composition according

taxan

hydrophobic

Prior art date

2022-03-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 239000002105 nanoparticle Substances 0.000 claims 13
• 239000000203 mixture Substances 0.000 claims 7
• 229930012538 Paclitaxel Natural products 0.000 claims 5
• 229960001592 paclitaxel Drugs 0.000 claims 5
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 5
• 239000012051 hydrophobic carrier Substances 0.000 claims 4
• 206010008263 Cervical dysplasia Diseases 0.000 claims 3
• XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 3
• 208000007951 cervical intraepithelial neoplasia Diseases 0.000 claims 3
• 230000002209 hydrophobic effect Effects 0.000 claims 3
• 229920002545 silicone oil Polymers 0.000 claims 3
• 239000004215 Carbon black (E152) Substances 0.000 claims 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
• 201000010881 cervical cancer Diseases 0.000 claims 2
• 229940086555 cyclomethicone Drugs 0.000 claims 2
• 229930195733 hydrocarbon Natural products 0.000 claims 2
• 150000002430 hydrocarbons Chemical class 0.000 claims 2
• 235000019271 petrolatum Nutrition 0.000 claims 2
• 239000008247 solid mixture Substances 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 239000004264 Petrolatum Substances 0.000 claims 1
• BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 1
• 229960001573 cabazitaxel Drugs 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 239000002480 mineral oil Substances 0.000 claims 1
• 235000010446 mineral oil Nutrition 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 239000012188 paraffin wax Substances 0.000 claims 1
• 235000019809 paraffin wax Nutrition 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 229940066842 petrolatum Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1