JP2023099039A5 - - Google Patents

Download PDF

Info

Publication number
JP2023099039A5
JP2023099039A5 JP2023068770A JP2023068770A JP2023099039A5 JP 2023099039 A5 JP2023099039 A5 JP 2023099039A5 JP 2023068770 A JP2023068770 A JP 2023068770A JP 2023068770 A JP2023068770 A JP 2023068770A JP 2023099039 A5 JP2023099039 A5 JP 2023099039A5
Authority
JP
Japan
Prior art keywords
amino acid
protein
peptide
acid sequence
ribosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023068770A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023099039A (ja
JP7702985B2 (ja
Filing date
Publication date
Priority claimed from JP2021564050A external-priority patent/JP7267458B2/ja
Application filed filed Critical
Publication of JP2023099039A publication Critical patent/JP2023099039A/ja
Publication of JP2023099039A5 publication Critical patent/JP2023099039A5/ja
Priority to JP2025105913A priority Critical patent/JP2025126268A/ja
Application granted granted Critical
Publication of JP7702985B2 publication Critical patent/JP7702985B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023068770A 2019-12-12 2023-04-19 非天然アミノ酸を含むペプチドの製造方法 Active JP7702985B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025105913A JP2025126268A (ja) 2019-12-12 2025-06-23 非天然アミノ酸を含むペプチドの製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019224297 2019-12-12
JP2019224297 2019-12-12
JP2021564050A JP7267458B2 (ja) 2019-12-12 2020-12-11 非天然アミノ酸を含むペプチドの製造方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021564050A Division JP7267458B2 (ja) 2019-12-12 2020-12-11 非天然アミノ酸を含むペプチドの製造方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025105913A Division JP2025126268A (ja) 2019-12-12 2025-06-23 非天然アミノ酸を含むペプチドの製造方法

Publications (3)

Publication Number Publication Date
JP2023099039A JP2023099039A (ja) 2023-07-11
JP2023099039A5 true JP2023099039A5 (https=) 2023-12-18
JP7702985B2 JP7702985B2 (ja) 2025-07-04

Family

ID=76329976

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021564050A Active JP7267458B2 (ja) 2019-12-12 2020-12-11 非天然アミノ酸を含むペプチドの製造方法
JP2023068770A Active JP7702985B2 (ja) 2019-12-12 2023-04-19 非天然アミノ酸を含むペプチドの製造方法
JP2025105913A Pending JP2025126268A (ja) 2019-12-12 2025-06-23 非天然アミノ酸を含むペプチドの製造方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021564050A Active JP7267458B2 (ja) 2019-12-12 2020-12-11 非天然アミノ酸を含むペプチドの製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025105913A Pending JP2025126268A (ja) 2019-12-12 2025-06-23 非天然アミノ酸を含むペプチドの製造方法

Country Status (6)

Country Link
US (1) US20230069218A1 (https=)
EP (1) EP4074829A4 (https=)
JP (3) JP7267458B2 (https=)
KR (1) KR20220113729A (https=)
CN (1) CN114787359A (https=)
WO (1) WO2021117848A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP4166664A1 (en) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-trna synthetase and use thereof
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
JPWO2024128195A1 (https=) 2022-12-12 2024-06-20
WO2024214303A1 (ja) 2023-04-14 2024-10-17 中外製薬株式会社 複数種類の標的分子との複合体を形成し得る目的分子のスクリーニング方法、及び当該スクリーニング方法を含む目的分子の製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH078289A (ja) * 1993-06-29 1995-01-13 Osaka Gas Co Ltd リボソームを用いたペプチドおよびタンパク質の合成法
JP4441170B2 (ja) * 2002-11-28 2010-03-31 独立行政法人理化学研究所 S12リボソームタンパク質に変異を有する大腸菌細胞抽出液及びそれを用いる無細胞系によるタンパク質の製造方法
CN101048506B (zh) * 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
WO2008073184A2 (en) * 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
JP5605602B2 (ja) 2007-03-26 2014-10-15 国立大学法人 東京大学 環状ペプチド化合物の合成方法
JP5818237B2 (ja) * 2010-09-09 2015-11-18 国立大学法人 東京大学 N−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法
EP2647721B1 (en) 2010-12-03 2019-02-27 The University of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP4166664A1 (en) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-trna synthetase and use thereof
JP7073250B2 (ja) 2016-03-03 2022-05-23 中外製薬株式会社 チオール基をアミノ基近傍に有するアミノ酸をn末端に持つ非環状ペプチド-核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド-核酸複合体ライブラリーの製造方法
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
RU2731211C1 (ru) * 2017-03-21 2020-08-31 Фуджифилм Корпорэйшн Пептидное соединение и способ его получения, композиция для скринингового использования и способ отбора пептидного соединения
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3904568A4 (en) 2018-12-26 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Mutated trna for codon expansion

Similar Documents

Publication Publication Date Title
JP2023099039A5 (https=)
JPWO2021117848A5 (https=)
Mai et al. The process of mammalian mitochondrial protein synthesis
KR102018863B1 (ko) 개선된 발현을 위해 박테리아 추출물 중 선택 단백질의 단백질분해 불활성화
CN114651065B (zh) 导入用于提高蛋白质生产性的单个条形码系统的信号肽超高速筛选方法
US20140287528A1 (en) Incorporation of methyl lysine into polypeptides
Kovalev et al. The expanding functions of cellular helicases: the tombusvirus RNA replication enhancer co-opts the plant eIF4AIII-like AtRH2 and the DDX5-like AtRH5 DEAD-box RNA helicases to promote viral asymmetric RNA replication
TWI893012B (zh) 真核半合成生物
JPH06500006A (ja) ユビキチン特異的プロテアーゼ
Collier et al. Competition between SsrA tagging and translational termination at weak stop codons in Escherichia coli
US20220411771A1 (en) Compositions and methods for detecting nucleic acid-protein interactions
JPWO2014119600A1 (ja) FlexibleDisplay法
JP2023174662A (ja) リシン誘導体を効率的に導入するアミノアシル-tRNAシンテターゼ
Cao et al. Insights into the post‐translational modifications of archaeal Sis10b (Alba): lysine‐16 is methylated, not acetylated, and this does not regulate transcription or growth
CN118726281A (zh) 吡咯赖氨酸氨酰基-tRNA合成酶突变体及其用途
Helmstaedt et al. Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site
US20240384267A1 (en) Compositions and methods for multiplex decoding of quadruplet codons
Komar et al. ACEMBLing a multiprotein transmembrane complex: the functional SecYEG-SecDF-YajC-YidC Holotranslocon protein secretase/insertase
US20240279646A1 (en) Peptide
Nanamiya et al. Towards an elucidation of the roles of the ribosome during different growth phases in Bacillus subtilis
EP4063377A1 (en) Modification of trna t-stem for enhancing n-methyl amino acid incorporation
WO2020139855A2 (en) Chimeric signal peptides for protein production
CN114032216B (zh) 双皮质肾上腺素样激酶1的新用途
Singh et al. Transplantation of Saccharomyces cerevisiae Rmd9p peptide into mammalian mitochondrial IF2 substitutes for the IF1 function in Escherichia coli
JP7453745B2 (ja) 毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法