JPWO2021117848A5 - - Google Patents
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- Publication number
- JPWO2021117848A5 JPWO2021117848A5 JP2021564050A JP2021564050A JPWO2021117848A5 JP WO2021117848 A5 JPWO2021117848 A5 JP WO2021117848A5 JP 2021564050 A JP2021564050 A JP 2021564050A JP 2021564050 A JP2021564050 A JP 2021564050A JP WO2021117848 A5 JPWO2021117848 A5 JP WO2021117848A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- peptide
- protein
- acid sequence
- ribosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 210000003705 ribosome Anatomy 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000013076 target substance Substances 0.000 claims 6
- 241000588724 Escherichia coli Species 0.000 claims 4
- 239000006166 lysate Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229910001425 magnesium ion Inorganic materials 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023068770A JP7702985B2 (ja) | 2019-12-12 | 2023-04-19 | 非天然アミノ酸を含むペプチドの製造方法 |
| JP2025105913A JP2025126268A (ja) | 2019-12-12 | 2025-06-23 | 非天然アミノ酸を含むペプチドの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019224297 | 2019-12-12 | ||
| JP2019224297 | 2019-12-12 | ||
| PCT/JP2020/046213 WO2021117848A1 (ja) | 2019-12-12 | 2020-12-11 | 非天然アミノ酸を含むペプチドの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023068770A Division JP7702985B2 (ja) | 2019-12-12 | 2023-04-19 | 非天然アミノ酸を含むペプチドの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021117848A1 JPWO2021117848A1 (https=) | 2021-06-17 |
| JPWO2021117848A5 true JPWO2021117848A5 (https=) | 2022-03-08 |
| JP7267458B2 JP7267458B2 (ja) | 2023-05-01 |
Family
ID=76329976
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564050A Active JP7267458B2 (ja) | 2019-12-12 | 2020-12-11 | 非天然アミノ酸を含むペプチドの製造方法 |
| JP2023068770A Active JP7702985B2 (ja) | 2019-12-12 | 2023-04-19 | 非天然アミノ酸を含むペプチドの製造方法 |
| JP2025105913A Pending JP2025126268A (ja) | 2019-12-12 | 2025-06-23 | 非天然アミノ酸を含むペプチドの製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023068770A Active JP7702985B2 (ja) | 2019-12-12 | 2023-04-19 | 非天然アミノ酸を含むペプチドの製造方法 |
| JP2025105913A Pending JP2025126268A (ja) | 2019-12-12 | 2025-06-23 | 非天然アミノ酸を含むペプチドの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230069218A1 (https=) |
| EP (1) | EP4074829A4 (https=) |
| JP (3) | JP7267458B2 (https=) |
| KR (1) | KR20220113729A (https=) |
| CN (1) | CN114787359A (https=) |
| WO (1) | WO2021117848A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| EP4166664A1 (en) | 2015-03-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-trna synthetase and use thereof |
| JP7187323B2 (ja) | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| JPWO2024128195A1 (https=) | 2022-12-12 | 2024-06-20 | ||
| WO2024214303A1 (ja) | 2023-04-14 | 2024-10-17 | 中外製薬株式会社 | 複数種類の標的分子との複合体を形成し得る目的分子のスクリーニング方法、及び当該スクリーニング方法を含む目的分子の製造方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH078289A (ja) * | 1993-06-29 | 1995-01-13 | Osaka Gas Co Ltd | リボソームを用いたペプチドおよびタンパク質の合成法 |
| JP4441170B2 (ja) * | 2002-11-28 | 2010-03-31 | 独立行政法人理化学研究所 | Ｓ１２リボソームタンパク質に変異を有する大腸菌細胞抽出液及びそれを用いる無細胞系によるタンパク質の製造方法 |
| CN101048506B (zh) * | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| WO2008073184A2 (en) * | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| JP5605602B2 (ja) | 2007-03-26 | 2014-10-15 | 国立大学法人 東京大学 | 環状ペプチド化合物の合成方法 |
| JP5818237B2 (ja) * | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| EP2647721B1 (en) | 2010-12-03 | 2019-02-27 | The University of Tokyo | Peptide with safer secondary structure, peptide library, and production methods for same |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| EP4166664A1 (en) | 2015-03-13 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-trna synthetase and use thereof |
| JP7073250B2 (ja) | 2016-03-03 | 2022-05-23 | 中外製薬株式会社 | チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法 |
| JP7187323B2 (ja) | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| RU2731211C1 (ru) * | 2017-03-21 | 2020-08-31 | Фуджифилм Корпорэйшн | Пептидное соединение и способ его получения, композиция для скринингового использования и способ отбора пептидного соединения |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3904568A4 (en) | 2018-12-26 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | Mutated trna for codon expansion |
-
2020
- 2020-12-11 JP JP2021564050A patent/JP7267458B2/ja active Active
- 2020-12-11 US US17/783,076 patent/US20230069218A1/en active Pending
- 2020-12-11 WO PCT/JP2020/046213 patent/WO2021117848A1/ja not_active Ceased
- 2020-12-11 EP EP20899836.9A patent/EP4074829A4/en active Pending
- 2020-12-11 CN CN202080085341.7A patent/CN114787359A/zh active Pending
- 2020-12-11 KR KR1020227022165A patent/KR20220113729A/ko active Pending
-
2023
- 2023-04-19 JP JP2023068770A patent/JP7702985B2/ja active Active
-
2025
- 2025-06-23 JP JP2025105913A patent/JP2025126268A/ja active Pending
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