JP2023090710A5 - - Google Patents
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- JP2023090710A5 JP2023090710A5 JP2023059996A JP2023059996A JP2023090710A5 JP 2023090710 A5 JP2023090710 A5 JP 2023090710A5 JP 2023059996 A JP2023059996 A JP 2023059996A JP 2023059996 A JP2023059996 A JP 2023059996A JP 2023090710 A5 JP2023090710 A5 JP 2023090710A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- chain variable
- variable region
- expression cassette
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000002865 immune cell Anatomy 0.000 claims 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 4
- 239000000611 antibody drug conjugate Substances 0.000 claims 3
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229940125644 antibody drug Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- LHMWTCWZARHLPV-CIUDSAMLSA-N Gln-Met-Ser Chemical compound CSCC[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)N)N LHMWTCWZARHLPV-CIUDSAMLSA-N 0.000 description 1
- ILDSIMPXNFWKLH-KATARQTJSA-N Leu-Thr-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O ILDSIMPXNFWKLH-KATARQTJSA-N 0.000 description 1
- PRSBSVAVOQOAMI-BJDJZHNGSA-N Lys-Ile-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CCCCN PRSBSVAVOQOAMI-BJDJZHNGSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811125056.4A CN110950953B (zh) | 2018-09-26 | 2018-09-26 | 抗b7-h3的单克隆抗体及其在细胞治疗中的应用 |
| CN201811125056.4 | 2018-09-26 | ||
| PCT/CN2019/108297 WO2020063787A1 (zh) | 2018-09-26 | 2019-09-26 | 抗b7-h3的单克隆抗体及其在细胞治疗中的应用 |
| JP2021542248A JP7333104B2 (ja) | 2018-09-26 | 2019-09-26 | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542248A Division JP7333104B2 (ja) | 2018-09-26 | 2019-09-26 | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023090710A JP2023090710A (ja) | 2023-06-29 |
| JP2023090710A5 true JP2023090710A5 (enExample) | 2024-08-20 |
| JP7578938B2 JP7578938B2 (ja) | 2024-11-07 |
Family
ID=69953353
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542248A Active JP7333104B2 (ja) | 2018-09-26 | 2019-09-26 | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 |
| JP2023059996A Active JP7578938B2 (ja) | 2018-09-26 | 2023-04-03 | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542248A Active JP7333104B2 (ja) | 2018-09-26 | 2019-09-26 | Ｂ７－ｈ３に対するモノクローナル抗体および細胞治療におけるその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12103973B2 (enExample) |
| EP (1) | EP3858856A4 (enExample) |
| JP (2) | JP7333104B2 (enExample) |
| KR (2) | KR102710963B1 (enExample) |
| CN (3) | CN115141279B (enExample) |
| WO (1) | WO2020063787A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
| CN117024590A (zh) * | 2020-04-22 | 2023-11-10 | 复星凯特生物科技有限公司 | 抗人b7-h3的单克隆抗体及其应用 |
| CN113754766A (zh) * | 2020-06-02 | 2021-12-07 | 明慧医药（上海）有限公司 | 抗b7-h3抗体及其制备和应用 |
| CN112877346B (zh) * | 2020-08-12 | 2023-01-03 | 山东兴瑞生物科技有限公司 | 抗b7-h3嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用 |
| CA3196549A1 (en) * | 2020-11-04 | 2022-05-12 | Bahram Valamehr | Engineered ipsc and immune effector cells for heterogenous tumor control |
| CN113527521B (zh) * | 2020-12-14 | 2022-05-31 | 广州百暨基因科技有限公司 | 一种抗b7h3嵌合抗原受体及其应用 |
| CN114763382B (zh) * | 2021-01-13 | 2024-12-17 | 博生吉医药科技(苏州)有限公司 | 靶向人cd276的单克隆抗体及其应用 |
| CN114763388B (zh) * | 2021-01-13 | 2024-12-17 | 博生吉医药科技(苏州)有限公司 | 靶向b7-h3的car-t细胞及其在急性髓系白血病治疗中的应用 |
| CN114763381B (zh) * | 2021-01-13 | 2025-01-28 | 博生吉医药科技(苏州)有限公司 | B7-h3嵌合抗原受体修饰的t细胞及其应用 |
| WO2023272924A1 (zh) * | 2021-06-30 | 2023-01-05 | 徐州医科大学 | 新型全人源抗人b7h3抗体和嵌合抗原受体及其用途 |
| CN113462651B (zh) * | 2021-06-30 | 2022-03-01 | 徐州医科大学 | 一种b7h3特异性抗性的car-nk细胞 |
| JP2024534661A (ja) * | 2021-09-30 | 2024-09-20 | バイオ－テラ ソリュ－ションズ，エルティーディー． | 抗ｂ７－ｈ３抗体及びその応用 |
| CN114081941A (zh) * | 2021-11-19 | 2022-02-25 | 上海奢旭企业管理中心(有限合伙) | B7-h4蛋白的制备方法及其制备抗过度免疫反应或抗细胞因子风暴的药品中的应用 |
| CN114380910B (zh) * | 2022-01-07 | 2023-04-28 | 苏州旭光科星抗体生物科技有限公司 | 靶向人b7-h3分子的人源化单克隆抗体及其应用 |
| CN114957484A (zh) * | 2022-04-30 | 2022-08-30 | 上海怡豪医疗科技有限公司 | 靶向实体肿瘤细胞b7-h3蛋白的car载体、car-t细胞及其构建方法和应用 |
| GB202209786D0 (en) * | 2022-07-04 | 2022-08-17 | Ucl Business Ltd | B7H3 Binders |
| CN119654342B (zh) * | 2022-07-28 | 2025-07-18 | 乐普创一生物科技（上海）有限公司 | 抗MerTK抗体及其用途 |
| CN116239699B (zh) * | 2022-11-10 | 2023-11-17 | 汕头普罗凯融生物医药科技有限公司 | 一种靶向cd276的嵌合抗原受体及其应用 |
| GB202217541D0 (en) * | 2022-11-24 | 2023-01-11 | Quell Therapeutics Ltd | Recombinant receptor |
| CN116284425B (zh) * | 2023-05-12 | 2023-07-21 | 北京纳百生物科技有限公司 | 一种抗壬基酚聚氧乙烯醚的单克隆抗体、试剂盒及应用 |
| CN117025541B (zh) * | 2023-08-15 | 2025-10-17 | 福建医科大学附属协和医院 | 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| CL2007003291A1 (es) * | 2006-11-15 | 2008-07-04 | Medarex Inc | Anticuerpo monoclonal humano aislado que enlaza la proteina btla o fragmentos del mismo; acido nucleico que lo codifica; metodo de produccion; composicion e inmunoconjugado que los comprende; y metodo para inhibir el crecimiento de celulas de tumor e |
| CN101607985B (zh) * | 2008-12-24 | 2013-03-27 | 中国科学院生物物理研究所 | 抗人cea的单克隆抗体，包含其的组合物，及其用途 |
| SG10201604336VA (en) * | 2010-03-04 | 2016-07-28 | Macrogenics Inc | Antibodies Reactive With B7-H3, Immunologically Active Fragments Thereof And Uses Thereof |
| PH12013502201A1 (en) * | 2011-04-25 | 2014-01-13 | Daiichi Sankyo Co Ltd | Anti-b7-h3 antibody |
| US20170275366A1 (en) * | 2014-07-29 | 2017-09-28 | Pfizer Inc. | EGFRvIII Specific Chimeric Antigen Receptor For Cancer Immunotherapy |
| EP3193933B1 (en) * | 2014-09-17 | 2021-04-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd276 antibodies (b7h3) |
| CN107034193B (zh) * | 2016-02-03 | 2020-06-05 | 北京马力喏生物科技有限公司 | 治疗b细胞白血病及b细胞淋巴瘤的治疗组合物 |
| HK1247214B (zh) * | 2016-03-04 | 2019-07-19 | 四川科伦博泰生物医药股份有限公司 | 一种pdl-1抗体、其药物组合物及其用途 |
| US10961311B2 (en) * | 2016-04-15 | 2021-03-30 | Macrogenics, Inc. | B7-H3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
| UY37278A (es) * | 2016-06-08 | 2018-01-31 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de fármaco y anticuerpos |
| JP2019526529A (ja) * | 2016-06-08 | 2019-09-19 | アッヴィ・インコーポレイテッド | 抗ｂ７−ｈ３抗体及び抗体薬物コンジュゲート |
| MX2018015285A (es) * | 2016-06-08 | 2019-09-18 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco. |
| WO2018226580A2 (en) * | 2017-06-05 | 2018-12-13 | Janssen Biotech, Inc. | Antibodies that specifically bind pd-1 and methods of use |
| CN107488230B (zh) * | 2017-09-01 | 2019-01-18 | 浙江大学 | 一种抗人CD79a胞外端蛋白的抗体、编码基因及应用 |
-
2018
- 2018-09-26 CN CN202210708261.3A patent/CN115141279B/zh active Active
- 2018-09-26 CN CN201811125056.4A patent/CN110950953B/zh active Active
- 2018-09-26 CN CN202210706555.2A patent/CN114957475B/zh active Active
-
2019
- 2019-09-26 EP EP19865028.5A patent/EP3858856A4/en active Pending
- 2019-09-26 JP JP2021542248A patent/JP7333104B2/ja active Active
- 2019-09-26 KR KR1020217012404A patent/KR102710963B1/ko active Active
- 2019-09-26 WO PCT/CN2019/108297 patent/WO2020063787A1/zh not_active Ceased
- 2019-09-26 KR KR1020247031726A patent/KR20240156612A/ko active Pending
- 2019-09-26 US US17/279,391 patent/US12103973B2/en active Active
-
2023
- 2023-04-03 JP JP2023059996A patent/JP7578938B2/ja active Active
-
2024
- 2024-08-26 US US18/815,779 patent/US20250051451A1/en active Pending
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