KR20240156612A - 항b7-h3의 모노클로널 항체 및 그가 세포 치료 중에서의 응용 - Google Patents

항b7-h3의 모노클로널 항체 및 그가 세포 치료 중에서의 응용 Download PDF

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KR20240156612A
KR20240156612A KR1020247031726A KR20247031726A KR20240156612A KR 20240156612 A KR20240156612 A KR 20240156612A KR 1020247031726 A KR1020247031726 A KR 1020247031726A KR 20247031726 A KR20247031726 A KR 20247031726A KR 20240156612 A KR20240156612 A KR 20240156612A
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South Korea
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antibody
ser
cells
leu
car
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Korean (ko)
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강시옹 후앙
리쿤 루오
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푸저우티셀테크 바이오테크놀로지 씨오 엘티디.
티셀테크 아이엔씨.
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Publication of KR20240156612A publication Critical patent/KR20240156612A/ko
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025121698A1 (ko) 2023-12-06 2025-06-12 주식회사 엘지에너지솔루션 파우치 필름 적층체, 파우치형 전지 케이스 및 파우치형 이차 전지

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021115333A1 (zh) * 2019-12-10 2021-06-17 苏州克睿基因生物科技有限公司 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用
CN113527487A (zh) * 2020-04-22 2021-10-22 复星凯特生物科技有限公司 抗人b7-h3的单克隆抗体及其应用
CN113754766A (zh) * 2020-06-02 2021-12-07 明慧医药(上海)有限公司 抗b7-h3抗体及其制备和应用
CN112877346B (zh) * 2020-08-12 2023-01-03 山东兴瑞生物科技有限公司 抗b7-h3嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用
US20230405121A1 (en) * 2020-11-04 2023-12-21 Fate Therapeutics, Inc. Engineered ipsc and immune effector cells for heterogenous tumor control
CN113480668A (zh) * 2020-12-14 2021-10-08 广州百暨基因科技有限公司 抗b7h3嵌合抗原受体及其应用
CN114763388B (zh) * 2021-01-13 2024-12-17 博生吉医药科技(苏州)有限公司 靶向b7-h3的car-t细胞及其在急性髓系白血病治疗中的应用
CN114763382B (zh) * 2021-01-13 2024-12-17 博生吉医药科技(苏州)有限公司 靶向人cd276的单克隆抗体及其应用
CN114763381B (zh) * 2021-01-13 2025-01-28 博生吉医药科技(苏州)有限公司 B7-h3嵌合抗原受体修饰的t细胞及其应用
WO2023272924A1 (zh) * 2021-06-30 2023-01-05 徐州医科大学 新型全人源抗人b7h3抗体和嵌合抗原受体及其用途
CN113462651B (zh) * 2021-06-30 2022-03-01 徐州医科大学 一种b7h3特异性抗性的car-nk细胞
EP4410839A4 (en) * 2021-09-30 2025-10-08 Bio Thera Solutions Ltd ANTI-B7-H3 ANTIBODY AND ITS USE
CN114081941A (zh) * 2021-11-19 2022-02-25 上海奢旭企业管理中心(有限合伙) B7-h4蛋白的制备方法及其制备抗过度免疫反应或抗细胞因子风暴的药品中的应用
CN114380910B (zh) * 2022-01-07 2023-04-28 苏州旭光科星抗体生物科技有限公司 靶向人b7-h3分子的人源化单克隆抗体及其应用
CN114957484A (zh) * 2022-04-30 2022-08-30 上海怡豪医疗科技有限公司 靶向实体肿瘤细胞b7-h3蛋白的car载体、car-t细胞及其构建方法和应用
GB202209786D0 (en) * 2022-07-04 2022-08-17 Ucl Business Ltd B7H3 Binders
CN120484126B (zh) * 2022-07-28 2025-11-18 乐普创一生物科技(上海)有限公司 抗MerTK抗体及其用途
CN116239699B (zh) * 2022-11-10 2023-11-17 汕头普罗凯融生物医药科技有限公司 一种靶向cd276的嵌合抗原受体及其应用
GB202217541D0 (en) * 2022-11-24 2023-01-11 Quell Therapeutics Ltd Recombinant receptor
CN116284425B (zh) * 2023-05-12 2023-07-21 北京纳百生物科技有限公司 一种抗壬基酚聚氧乙烯醚的单克隆抗体、试剂盒及应用
CN117025541B (zh) * 2023-08-15 2025-10-17 福建医科大学附属协和医院 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途
WO2025256632A1 (zh) * 2024-06-14 2025-12-18 长春金赛药业有限责任公司 靶向b7-h3和psma的双特异性抗体及抗体-药物偶联物
WO2026020799A1 (zh) * 2024-07-24 2026-01-29 昕传生物科技(北京)有限公司 靶向b7-h3的抗体、嵌合抗原受体及其应用
WO2026026852A1 (zh) * 2024-07-31 2026-02-05 郑州大学 一种靶向b7h3的car-t细胞及其抗肿瘤应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
US5876950A (en) * 1995-01-26 1999-03-02 Bristol-Myers Squibb Company Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
EP1235842A4 (en) 1999-10-15 2003-04-23 Univ Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
MX2009005189A (es) * 2006-11-15 2009-06-30 Medarex Inc Anticuerpos humanos monoclonales para btla y metodos de uso.
CN101607985B (zh) * 2008-12-24 2013-03-27 中国科学院生物物理研究所 抗人cea的单克隆抗体,包含其的组合物,及其用途
DK2542256T3 (da) * 2010-03-04 2019-08-26 Macrogenics Inc Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
EP2703486B1 (en) * 2011-04-25 2018-03-07 Daiichi Sankyo Company, Limited Anti-b7-h3 antibody
RU2017102769A (ru) * 2014-07-29 2018-08-28 Пфайзер Инк. EGFRvIII СПЕЦИФИЧЕСКИЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ ИММУНОТЕРАПИИ РАКА
JP6613304B2 (ja) * 2014-09-17 2019-12-04 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 抗cd276抗体(b7h3)
CN107034193B (zh) * 2016-02-03 2020-06-05 北京马力喏生物科技有限公司 治疗b细胞白血病及b细胞淋巴瘤的治疗组合物
RU2693661C2 (ru) * 2016-03-04 2019-07-03 Сычуань Келунь-Байотек Байофармасьютикал Ко., Лтд. Антитело против pdl-1, его фармацевтическая композиция и применение
CN109069633A (zh) * 2016-04-15 2018-12-21 宏观基因有限公司 新颖的b7-h3-结合分子、其抗体药物缀合物及其使用方法
CN109641962A (zh) * 2016-06-08 2019-04-16 艾伯维公司 抗b7-h3抗体和抗体药物偶联物
JP2019526529A (ja) * 2016-06-08 2019-09-19 アッヴィ・インコーポレイテッド 抗b7−h3抗体及び抗体薬物コンジュゲート
RS61828B1 (sr) * 2016-06-08 2021-06-30 Abbvie Inc Anti-b7-h3 antitela i antitelske konjugacije lekova
US10995149B2 (en) * 2017-06-05 2021-05-04 Janssen Biotech, Inc. Antibodies that specifically bind PD-1 and methods of use
CN107488230B (zh) * 2017-09-01 2019-01-18 浙江大学 一种抗人CD79a胞外端蛋白的抗体、编码基因及应用

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2025121698A1 (ko) 2023-12-06 2025-06-12 주식회사 엘지에너지솔루션 파우치 필름 적층체, 파우치형 전지 케이스 및 파우치형 이차 전지

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