JP2023029957A5 - - Google Patents
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- JP2023029957A5 JP2023029957A5 JP2022193738A JP2022193738A JP2023029957A5 JP 2023029957 A5 JP2023029957 A5 JP 2023029957A5 JP 2022193738 A JP2022193738 A JP 2022193738A JP 2022193738 A JP2022193738 A JP 2022193738A JP 2023029957 A5 JP2023029957 A5 JP 2023029957A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- polypeptide
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428492P | 2016-11-30 | 2016-11-30 | |
| US62/428,492 | 2016-11-30 | ||
| US201762553313P | 2017-09-01 | 2017-09-01 | |
| US62/553,313 | 2017-09-01 | ||
| JP2019529240A JP7649624B2 (ja) | 2016-11-30 | 2017-11-30 | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
| PCT/US2017/064081 WO2018102616A1 (en) | 2016-11-30 | 2017-11-30 | Fracture targeted bone regeneration through parathyroid hormone receptor stimulation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529240A Division JP7649624B2 (ja) | 2016-11-30 | 2017-11-30 | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023029957A JP2023029957A (ja) | 2023-03-07 |
| JP2023029957A5 true JP2023029957A5 (enExample) | 2023-07-28 |
Family
ID=62241919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529240A Active JP7649624B2 (ja) | 2016-11-30 | 2017-11-30 | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
| JP2022193738A Pending JP2023029957A (ja) | 2016-11-30 | 2022-12-02 | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529240A Active JP7649624B2 (ja) | 2016-11-30 | 2017-11-30 | 副甲状腺ホルモン受容体刺激を介する、骨折をターゲティングした骨再生 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20200317745A1 (enExample) |
| EP (1) | EP3548012A4 (enExample) |
| JP (2) | JP7649624B2 (enExample) |
| CN (1) | CN110114065A (enExample) |
| AU (1) | AU2017367699B2 (enExample) |
| CA (1) | CA3045458A1 (enExample) |
| IL (1) | IL266977B2 (enExample) |
| MX (1) | MX2019006189A (enExample) |
| WO (1) | WO2018102616A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL266977B2 (en) * | 2016-11-30 | 2024-01-01 | Purdue Research Foundation | Fracture-targeted bone regeneration using thyroid hormone receptor stimulation |
| EP3796941A4 (en) * | 2018-05-30 | 2022-12-28 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| CN110551201B (zh) * | 2019-08-26 | 2020-04-28 | 杭州彗搏科技有限公司 | 一种新型骨形成蛋白2来源的环肽、制备方法及其应用 |
| BR112022004462A2 (pt) * | 2019-09-12 | 2022-05-31 | Radius Health Inc | Métodos para melhorar a fusão espinhal com abaloparatida |
| CN112646042A (zh) * | 2019-10-10 | 2021-04-13 | 陕西麦科奥特科技有限公司 | 活性多肽化合物 |
| JP2023540098A (ja) * | 2020-09-03 | 2023-09-21 | チェン アーヴィン エス．ワイ． | 可溶性アルカリホスファターゼ構築物及び可溶性アルカリホスファターゼ構築物をコードするポリヌクレオチドを含む発現ベクター |
| EP4232075A4 (en) * | 2020-10-26 | 2024-12-18 | Purdue Research Foundation | Compounds,compositions and methods of use to treat spinal fusions |
| MX2023004796A (es) * | 2020-10-26 | 2023-07-18 | Purdue Research Foundation | Compuestos, composiciones y metodos de uso para tratar fracturas oseas. |
| JP2024502334A (ja) * | 2021-01-05 | 2024-01-18 | ラジウス ヘルス，インコーポレイテッド | アバロパラチドを用いた長骨骨折の治療 |
| US20260185102A1 (en) * | 2021-11-02 | 2026-07-02 | Rena Therapeutics Inc. | Ligand-binding nucleic acid complex |
| US20250295725A1 (en) * | 2022-01-14 | 2025-09-25 | Purdue Research Foundation | Bone targeted treatment in osteogenesis imperfecta |
| WO2024246840A1 (en) * | 2023-06-01 | 2024-12-05 | Radius Health, Inc. | Methods for identification and quantitation of abaloparatide and related peptide impurities |
| WO2025019691A1 (en) * | 2023-07-19 | 2025-01-23 | Zymeron Corporation | Drug conjugates for bone marrow protection |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992011286A1 (en) * | 1990-12-21 | 1992-07-09 | Allelix Biopharmaceuticals Inc. | Oxidation resistant variants of parathyroid hormone |
| WO1995002610A1 (en) * | 1993-07-13 | 1995-01-26 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU757658B2 (en) * | 1998-03-09 | 2003-02-27 | Zealand Pharma A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| JP2000327583A (ja) | 1999-05-17 | 2000-11-28 | Medei Sci Puraningu:Kk | 骨指向性ホルモン誘導体 |
| WO2004062588A2 (en) * | 2003-01-06 | 2004-07-29 | University Of Utah | Water-soluble polymeric bone-targeting drug delivery system |
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| US7863238B2 (en) | 2004-06-10 | 2011-01-04 | Saint Louis University | Proteins with an attached short peptide of acidic amino acids |
| US20110046059A1 (en) * | 2005-09-06 | 2011-02-24 | Zelos Therapeutics, Inc. | Pharmaceutically acceptable formulations/compositions for peptidyl drugs |
| DK2073789T3 (da) | 2006-10-03 | 2019-08-05 | Radius Health Inc | Stabil sammensætning omfattende et knogle-anabolisk protein, nemlig en pthrp-analog, og anvendelser deraf |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| ES2583002T3 (es) * | 2007-04-09 | 2016-09-16 | The Board Of Trustees Of The University Of Arkansas | Proteínas de fusión de un dominio de enlazamiento a colágeno y hormona paratiroidea |
| DK2662448T3 (en) | 2007-05-11 | 2017-03-20 | Alexion Pharma Inc | Bone-targeted alkaline phosphatase, kits and methods for its use |
| WO2009141823A2 (en) * | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| WO2012111852A1 (ja) | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
| KR20140047043A (ko) * | 2011-04-22 | 2014-04-21 | 라디우스 헬쓰, 인코포레이티드 | PTH, PTHrP를 위한 약물 전달 방법 및 관련 펩티드 |
| CN102824647B (zh) * | 2011-06-13 | 2014-07-23 | 香港中文大学 | 基于小核酸药物成骨治疗的骨靶向递送系统及其制备方法 |
| CA2883707A1 (en) * | 2012-08-28 | 2014-03-06 | The Governors Of The University Of Alberta | Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods of making and using thereof |
| EP3016674A4 (en) | 2013-06-23 | 2017-03-15 | Wisconsin Alumni Research Foundation | Alpha-/beta-polypeptide analogs of parathyroid hormone (pth) and method of using same |
| EP4137147A3 (en) * | 2015-03-03 | 2023-04-05 | Radius Health, Inc. | Uses of abaloparatide in reducing fracture risk |
| US10279044B2 (en) * | 2015-05-29 | 2019-05-07 | Purdue Research Foundation | Bone fracture repair by targeting of agents that promote bone healing |
| CN106039316B (zh) * | 2016-05-03 | 2019-04-02 | 同济大学 | 一种基于多肽构建的成骨细胞靶向载体及其制备与应用 |
| IL266977B2 (en) * | 2016-11-30 | 2024-01-01 | Purdue Research Foundation | Fracture-targeted bone regeneration using thyroid hormone receptor stimulation |
| MX2023004796A (es) * | 2020-10-26 | 2023-07-18 | Purdue Research Foundation | Compuestos, composiciones y metodos de uso para tratar fracturas oseas. |
-
2017
- 2017-11-30 IL IL266977A patent/IL266977B2/en unknown
- 2017-11-30 US US16/464,164 patent/US20200317745A1/en not_active Abandoned
- 2017-11-30 CN CN201780073942.4A patent/CN110114065A/zh active Pending
- 2017-11-30 CA CA3045458A patent/CA3045458A1/en active Pending
- 2017-11-30 AU AU2017367699A patent/AU2017367699B2/en active Active
- 2017-11-30 WO PCT/US2017/064081 patent/WO2018102616A1/en not_active Ceased
- 2017-11-30 JP JP2019529240A patent/JP7649624B2/ja active Active
- 2017-11-30 MX MX2019006189A patent/MX2019006189A/es unknown
- 2017-11-30 EP EP17875427.1A patent/EP3548012A4/en active Pending
-
2020
- 2020-03-31 US US16/836,366 patent/US10960054B2/en active Active
-
2021
- 2021-02-24 US US17/184,400 patent/US20210283227A1/en active Pending
-
2022
- 2022-12-02 JP JP2022193738A patent/JP2023029957A/ja active Pending
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