BR112022004462A2 - Métodos para melhorar a fusão espinhal com abaloparatida - Google Patents
Métodos para melhorar a fusão espinhal com abaloparatidaInfo
- Publication number
- BR112022004462A2 BR112022004462A2 BR112022004462A BR112022004462A BR112022004462A2 BR 112022004462 A2 BR112022004462 A2 BR 112022004462A2 BR 112022004462 A BR112022004462 A BR 112022004462A BR 112022004462 A BR112022004462 A BR 112022004462A BR 112022004462 A2 BR112022004462 A2 BR 112022004462A2
- Authority
- BR
- Brazil
- Prior art keywords
- abaloparatide
- spinal fusion
- methods
- spinal
- subject
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title abstract 5
- BVISQZFBLRSESR-XSCWXTNMSA-N abaloparatide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C1=CN=CN1 BVISQZFBLRSESR-XSCWXTNMSA-N 0.000 title abstract 4
- 229950001959 abaloparatide Drugs 0.000 title abstract 4
- 108010038051 abaloparatide Proteins 0.000 title abstract 4
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 206010041569 spinal fracture Diseases 0.000 abstract 2
- 206010058907 Spinal deformity Diseases 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
métodos para melhorar a fusão espinhal com abaloparatida. são providos neste documento métodos para intensificar a fusão espinhal e a formação óssea em indivíduos com fraturas espinhais, deformidades ou instabilidade na coluna. o método inclui a administração (por exemplo, por via subcutânea ou transdérmica) de uma quantidade terapeuticamente eficaz de abaloparatida ao indivíduo. em um aspecto, é provido neste documento um método para intensificar a fusão espinhal, incluindo a administração a um indivíduo com fratura espinhal, uma quantidade terapeuticamente eficaz de abaloparatida, de modo que a fusão espinhal seja intensificada no indivíduo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962899633P | 2019-09-12 | 2019-09-12 | |
| PCT/US2020/050729 WO2021051082A1 (en) | 2019-09-12 | 2020-09-14 | Methods of improving spinal fusion with abaloparatide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022004462A2 true BR112022004462A2 (pt) | 2022-05-31 |
Family
ID=74866536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022004462A BR112022004462A2 (pt) | 2019-09-12 | 2020-09-14 | Métodos para melhorar a fusão espinhal com abaloparatida |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220193203A1 (pt) |
| EP (1) | EP4027899A4 (pt) |
| CN (1) | CN114364327A (pt) |
| BR (1) | BR112022004462A2 (pt) |
| CL (2) | CL2022000590A1 (pt) |
| MX (1) | MX2022002979A (pt) |
| WO (1) | WO2021051082A1 (pt) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS49707B (sr) * | 1997-09-09 | 2007-12-31 | F.Hoffmann-La Roche Ag., | Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju |
| WO2005038453A1 (en) * | 2003-10-17 | 2005-04-28 | Medvet Science Pty Ltd | Early assessment of motor recovery in spinal cord injury patients |
| WO2016141250A1 (en) * | 2015-03-03 | 2016-09-09 | Radius Health, Inc. | USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK |
| PL3359241T3 (pl) * | 2015-10-09 | 2021-12-20 | Radius Health, Inc. | Formulacje analogów pthrp, plastry przezskórne je zawierające i ich zastosowania |
-
2020
- 2020-09-14 MX MX2022002979A patent/MX2022002979A/es unknown
- 2020-09-14 CN CN202080063607.8A patent/CN114364327A/zh active Pending
- 2020-09-14 WO PCT/US2020/050729 patent/WO2021051082A1/en unknown
- 2020-09-14 EP EP20862156.5A patent/EP4027899A4/en active Pending
- 2020-09-14 BR BR112022004462A patent/BR112022004462A2/pt unknown
-
2022
- 2022-03-10 CL CL2022000590A patent/CL2022000590A1/es unknown
- 2022-03-11 US US17/692,818 patent/US20220193203A1/en active Pending
-
2023
- 2023-04-06 CL CL2023001017A patent/CL2023001017A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021051082A1 (en) | 2021-03-18 |
| CN114364327A (zh) | 2022-04-15 |
| MX2022002979A (es) | 2022-06-16 |
| EP4027899A4 (en) | 2023-08-16 |
| CL2022000590A1 (es) | 2022-11-11 |
| US20220193203A1 (en) | 2022-06-23 |
| CL2023001017A1 (es) | 2023-12-11 |
| EP4027899A1 (en) | 2022-07-20 |
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