JP2023021277A5 - - Google Patents
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- Publication number
- JP2023021277A5 JP2023021277A5 JP2022198545A JP2022198545A JP2023021277A5 JP 2023021277 A5 JP2023021277 A5 JP 2023021277A5 JP 2022198545 A JP2022198545 A JP 2022198545A JP 2022198545 A JP2022198545 A JP 2022198545A JP 2023021277 A5 JP2023021277 A5 JP 2023021277A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- pyrrolo
- trifluoromethyl
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- -1 cyano, phenyl Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- QVXZGMUKOWYSOX-UHFFFAOYSA-N 4-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-2-one Chemical compound N1N=CC=2C1=NC=CC=2C1=CC(NC(=C1)N1C(CCCC1)C(F)(F)F)=O QVXZGMUKOWYSOX-UHFFFAOYSA-N 0.000 claims 2
- CSXOYNVGINDZNB-UHFFFAOYSA-N 4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-2-one Chemical compound N1C=CC=2C1=NC=CC=2C1=CC(NC(=C1)C1=C(C=CC=C1)C(F)(F)F)=O CSXOYNVGINDZNB-UHFFFAOYSA-N 0.000 claims 2
- DOJFVPVHXQICAN-UHFFFAOYSA-N 4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-2-one Chemical compound N1C=CC=2C1=NC=CC=2C1=CC(NC(=C1)N1C(CCCC1)C(F)(F)F)=O DOJFVPVHXQICAN-UHFFFAOYSA-N 0.000 claims 2
- JDKCFBIRILXMFJ-UHFFFAOYSA-N 4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[3-(trifluoromethyl)morpholin-4-yl]-1H-pyridin-2-one Chemical compound N1C=CC=2C1=NC=CC=2C1=CC(NC(=C1)N1C(COCC1)C(F)(F)F)=O JDKCFBIRILXMFJ-UHFFFAOYSA-N 0.000 claims 2
- CXYDPZLJNIQRAZ-UHFFFAOYSA-N 4-(2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[4-ethylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound C1(CC1)C1=CC=2C(=NC=CC=2C2=CC(NC(=C2)N2C(CN(CC2)S(=O)(=O)CC)C(F)(F)F)=O)N1 CXYDPZLJNIQRAZ-UHFFFAOYSA-N 0.000 claims 2
- IBNJRAAEJIHRLO-UHFFFAOYSA-N 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-2-one Chemical compound CC1=CC=2C(=NC=CC=2C2=CC(NC(=C2)N2C(CCCC2)C(F)(F)F)=O)N1 IBNJRAAEJIHRLO-UHFFFAOYSA-N 0.000 claims 2
- SDFBGSCILLFDMY-UHFFFAOYSA-N 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-morpholin-4-yl-1H-pyridin-2-one Chemical compound CC1=CC=2C(=NC=CC=2C2=CC(NC(=C2)N2CCOCC2)=O)N1 SDFBGSCILLFDMY-UHFFFAOYSA-N 0.000 claims 2
- AINQHQYRXCJWMT-UHFFFAOYSA-N 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-pyridin-3-yl-1H-pyridin-2-one Chemical compound CC1=CC=2C(=NC=CC=2C2=CC(NC(=C2)C=2C=NC=CC=2)=O)N1 AINQHQYRXCJWMT-UHFFFAOYSA-N 0.000 claims 2
- INUVCRPQYQBTTA-UHFFFAOYSA-N 4-[2-(5-methylthiophen-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-6-[3-(trifluoromethyl)morpholin-4-yl]-1H-pyridin-2-one Chemical compound CC1=CC=C(S1)C1=CC=2C(=NC=CC=2C2=CC(NC(=C2)N2C(COCC2)C(F)(F)F)=O)N1 INUVCRPQYQBTTA-UHFFFAOYSA-N 0.000 claims 2
- PUNDGYRIKMMQHI-UHFFFAOYSA-N 6-(2-chlorophenyl)-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound ClC1=C(C=CC=C1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C PUNDGYRIKMMQHI-UHFFFAOYSA-N 0.000 claims 2
- KUHXRVPOFWEIIL-UHFFFAOYSA-N 6-(2-chlorophenyl)-4-(2-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound ClC1=C(C=CC=C1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C=1C=NC=CC=1 KUHXRVPOFWEIIL-UHFFFAOYSA-N 0.000 claims 2
- IBWQEYYDUJEVFR-UHFFFAOYSA-N 6-(2-chlorophenyl)-4-[2-(1,3-oxazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyridin-2-one Chemical compound ClC1=C(C=CC=C1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C1=CN=CO1 IBWQEYYDUJEVFR-UHFFFAOYSA-N 0.000 claims 2
- WWHGOOFSNVJOAU-UHFFFAOYSA-N 6-(2-phenylpyrrolidin-1-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound C1(=CC=CC=C1)C1N(CCC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC=C2 WWHGOOFSNVJOAU-UHFFFAOYSA-N 0.000 claims 2
- FPZSPEGMNPCQHE-UHFFFAOYSA-N 6-(3-methylpyridin-4-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound CC=1C=NC=CC=1C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC=C2 FPZSPEGMNPCQHE-UHFFFAOYSA-N 0.000 claims 2
- HUCPWIDCPVSLDW-UHFFFAOYSA-N 6-[2-(trifluoromethyl)piperidin-1-yl]-4-[2-[2-(trifluoromethyl)pyrimidin-5-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyridin-2-one Chemical compound FC(C1N(CCCC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C=1C=NC(=NC=1)C(F)(F)F)(F)F HUCPWIDCPVSLDW-UHFFFAOYSA-N 0.000 claims 2
- LRTZISIKPSKAIP-UHFFFAOYSA-N 6-[2-(trifluoromethyl)piperidin-1-yl]-4-[2-[5-(trifluoromethyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyridin-2-one Chemical compound FC(C1N(CCCC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C=1C=NC=C(C=1)C(F)(F)F)(F)F LRTZISIKPSKAIP-UHFFFAOYSA-N 0.000 claims 2
- SCKYJZZLWPCYAC-UHFFFAOYSA-N 6-[2-(trifluoromethyl)piperidin-1-yl]-4-[2-[6-(trifluoromethyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyridin-2-one Chemical compound FC(C1N(CCCC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C=1C=NC(=CC=1)C(F)(F)F)(F)F SCKYJZZLWPCYAC-UHFFFAOYSA-N 0.000 claims 2
- LDLMFSXKVWKENB-UHFFFAOYSA-N 6-[3-(trifluoromethyl)morpholin-4-yl]-4-[2-[3-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyridin-2-one Chemical compound FC(C1N(CCOC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C1=CC(=CC=C1)C(F)(F)F)(F)F LDLMFSXKVWKENB-UHFFFAOYSA-N 0.000 claims 2
- DNRNHHBDLRQHAU-UHFFFAOYSA-N 6-[4-[(4-fluorophenyl)methylsulfonyl]-2-(trifluoromethyl)piperazin-1-yl]-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound FC1=CC=C(C=C1)CS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC=C2)C(F)(F)F DNRNHHBDLRQHAU-UHFFFAOYSA-N 0.000 claims 2
- VAWHMYMAEPEZTK-UHFFFAOYSA-N 6-[4-ethylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound C(C)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC=C2)C(F)(F)F VAWHMYMAEPEZTK-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- KDDZUAZEHFIWMN-UHFFFAOYSA-N 4-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-2-one Chemical compound N1N=CC=2C1=NC=CC=2C1=CC(NC(=C1)C1=C(C=CC=C1)C(F)(F)F)=O KDDZUAZEHFIWMN-UHFFFAOYSA-N 0.000 claims 1
- UHLMTCFPIOAJRK-UHFFFAOYSA-N 4-(2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-2-one Chemical compound C1(CC1)C1=CC=2C(=NC=CC=2C2=CC(NC(=C2)C2=C(C=CC=C2)C(F)(F)F)=O)N1 UHLMTCFPIOAJRK-UHFFFAOYSA-N 0.000 claims 1
- NYYFCAZTWFWZRD-UHFFFAOYSA-N 4-[2-[4-ethylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-6-oxo-1H-pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carbonitrile Chemical compound C(C)S(=O)(=O)N1CC(N(CC1)C=1NC(C=C(C=1)C1=C2C(=NC=C1)NC(=C2)C#N)=O)C(F)(F)F NYYFCAZTWFWZRD-UHFFFAOYSA-N 0.000 claims 1
- JOVIYZVQVRVMNU-UHFFFAOYSA-N 4-[2-oxo-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carbonitrile Chemical compound O=C1NC(=CC(=C1)C1=C2C(=NC=C1)NC(=C2)C#N)C1=C(C=CC=C1)C(F)(F)F JOVIYZVQVRVMNU-UHFFFAOYSA-N 0.000 claims 1
- NCBUSDZFMYRPKX-UHFFFAOYSA-N 6-[4-ethylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound C(C)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NC(=C2)C)C(F)(F)F NCBUSDZFMYRPKX-UHFFFAOYSA-N 0.000 claims 1
- GJZVFKVARNDTAZ-UHFFFAOYSA-N 6-[4-methylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-pyridin-2-one Chemical compound CS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)C1=C2C(=NC=C1)NN=C2)C(F)(F)F GJZVFKVARNDTAZ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187519 | 2017-08-23 | ||
| EP17187519.8 | 2017-08-23 | ||
| JP2020510099A JP7199738B2 (ja) | 2017-08-23 | 2018-08-23 | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
| PCT/EP2018/072785 WO2019038384A1 (en) | 2017-08-23 | 2018-08-23 | AZAINDOLYLPYRIDONE AND DIAZAINDOLYLPYRIDONE COMPOUNDS |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510099A Division JP7199738B2 (ja) | 2017-08-23 | 2018-08-23 | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023021277A JP2023021277A (ja) | 2023-02-10 |
| JP2023021277A5 true JP2023021277A5 (https=) | 2023-09-25 |
Family
ID=59686871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510099A Active JP7199738B2 (ja) | 2017-08-23 | 2018-08-23 | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
| JP2022198545A Ceased JP2023021277A (ja) | 2017-08-23 | 2022-12-13 | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510099A Active JP7199738B2 (ja) | 2017-08-23 | 2018-08-23 | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11498919B2 (https=) |
| EP (2) | EP3672967B1 (https=) |
| JP (2) | JP7199738B2 (https=) |
| KR (1) | KR102731945B1 (https=) |
| CN (3) | CN111247144B (https=) |
| AU (1) | AU2018321135B2 (https=) |
| CY (1) | CY1124818T1 (https=) |
| DK (1) | DK3672967T3 (https=) |
| ES (1) | ES2902346T3 (https=) |
| HR (1) | HRP20211999T1 (https=) |
| HU (1) | HUE057818T2 (https=) |
| IL (3) | IL302355A (https=) |
| LT (1) | LT3672967T (https=) |
| PL (1) | PL3672967T3 (https=) |
| PT (1) | PT3672967T (https=) |
| RS (1) | RS62785B1 (https=) |
| SI (1) | SI3672967T1 (https=) |
| SM (1) | SMT202100718T1 (https=) |
| TW (2) | TW202325708A (https=) |
| WO (1) | WO2019038384A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3672967T1 (sl) * | 2017-08-23 | 2022-04-29 | Sprint Bioscience Ab | Spojine azaindolilpiridona in diazaindolilpiridona |
| CA3199999A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection |
| CN117241800A (zh) * | 2020-11-25 | 2023-12-15 | 德西费拉制药有限责任公司 | Vps34抑制剂的抗病毒活性 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1154024B (it) * | 1982-09-22 | 1987-01-21 | Lepetit Spa | Derivati pridinici e procedimento per la loro produzione |
| EP2354140A1 (en) | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| US20110201599A1 (en) * | 2008-07-03 | 2011-08-18 | Exelixis, Inc. | CDK Modulators |
| CA2795422A1 (en) | 2010-04-19 | 2011-10-27 | Abbvie Inc. | Pyrrolopyridine inhibitors of kinases |
| WO2012085815A1 (en) | 2010-12-21 | 2012-06-28 | Novartis Ag | Bi-heteroaryl compounds as vps34 inhibitors |
| DK2655375T3 (en) | 2010-12-23 | 2015-03-09 | Sanofi Sa | PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| CN103450152B (zh) | 2012-06-04 | 2015-11-18 | 济南海乐医药技术开发有限公司 | 基于吲唑、吲哚或氮杂吲唑、氮杂吲哚的双芳基脲类结构抗肿瘤药物 |
| FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2015108861A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| ES2821400T3 (es) | 2016-02-19 | 2021-04-26 | Sprint Bioscience Ab | Compuestos de 6-heterociclil-4-morfolin-4-ilpiridin-2-ona útiles para el tratamiento del cáncer y la diabetes |
| TWI721104B (zh) | 2016-02-19 | 2021-03-11 | 瑞典商斯普林特生物科技公司 | 6‐芳基或6‐雜芳基‐4‐嗎啉‐4‐芳基‐吡啶‐2‐酮化合物 |
| SI3672967T1 (sl) * | 2017-08-23 | 2022-04-29 | Sprint Bioscience Ab | Spojine azaindolilpiridona in diazaindolilpiridona |
-
2018
- 2018-08-23 SI SI201830500T patent/SI3672967T1/sl unknown
- 2018-08-23 JP JP2020510099A patent/JP7199738B2/ja active Active
- 2018-08-23 TW TW111140665A patent/TW202325708A/zh unknown
- 2018-08-23 LT LTEPPCT/EP2018/072785T patent/LT3672967T/lt unknown
- 2018-08-23 PT PT187593074T patent/PT3672967T/pt unknown
- 2018-08-23 EP EP18759307.4A patent/EP3672967B1/en active Active
- 2018-08-23 SM SM20210718T patent/SMT202100718T1/it unknown
- 2018-08-23 IL IL302355A patent/IL302355A/en unknown
- 2018-08-23 TW TW107129491A patent/TWI785101B/zh not_active IP Right Cessation
- 2018-08-23 KR KR1020207006930A patent/KR102731945B1/ko active Active
- 2018-08-23 DK DK18759307.4T patent/DK3672967T3/da active
- 2018-08-23 CN CN201880054872.2A patent/CN111247144B/zh active Active
- 2018-08-23 PL PL18759307T patent/PL3672967T3/pl unknown
- 2018-08-23 WO PCT/EP2018/072785 patent/WO2019038384A1/en not_active Ceased
- 2018-08-23 HR HRP20211999TT patent/HRP20211999T1/hr unknown
- 2018-08-23 US US16/638,727 patent/US11498919B2/en active Active
- 2018-08-23 RS RS20211605A patent/RS62785B1/sr unknown
- 2018-08-23 AU AU2018321135A patent/AU2018321135B2/en not_active Ceased
- 2018-08-23 EP EP21196341.8A patent/EP4001278A1/en not_active Withdrawn
- 2018-08-23 CN CN202310536658.3A patent/CN116589462A/zh active Pending
- 2018-08-23 CN CN202310536605.1A patent/CN116589461A/zh active Pending
- 2018-08-23 HU HUE18759307A patent/HUE057818T2/hu unknown
- 2018-08-23 ES ES18759307T patent/ES2902346T3/es active Active
-
2020
- 2020-02-20 IL IL272792A patent/IL272792B/en unknown
-
2022
- 2022-01-03 CY CY20221100001T patent/CY1124818T1/el unknown
- 2022-04-25 IL IL292482A patent/IL292482B2/en unknown
- 2022-10-11 US US18/045,605 patent/US20230322772A1/en not_active Abandoned
- 2022-12-13 JP JP2022198545A patent/JP2023021277A/ja not_active Ceased
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