JP2022552187A - 選択的カリウムチャネルモジュレータの固体状態結晶形 - Google Patents

選択的カリウムチャネルモジュレータの固体状態結晶形 Download PDF

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Publication number
JP2022552187A
JP2022552187A JP2022520908A JP2022520908A JP2022552187A JP 2022552187 A JP2022552187 A JP 2022552187A JP 2022520908 A JP2022520908 A JP 2022520908A JP 2022520908 A JP2022520908 A JP 2022520908A JP 2022552187 A JP2022552187 A JP 2022552187A
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solid state
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JP2022552187A5 (https=
Inventor
ポール ロバート ビチラー
ジャン－ジャック エー． カデュー
マシュー デイヴィッド タンディ
グレゴリー エヌ． ビーッチ
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Liquid Crystal Substances (AREA)
  • Transmitters (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
JP2022520908A 2019-10-10 2020-10-09 選択的カリウムチャネルモジュレータの固体状態結晶形 Pending JP2022552187A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962913574P 2019-10-10 2019-10-10
US62/913,574 2019-10-10
PCT/US2020/055129 WO2021072307A1 (en) 2019-10-10 2020-10-09 Solid state crystalline forms of a selective potassium channel modulator

Publications (2)

Publication Number Publication Date
JP2022552187A true JP2022552187A (ja) 2022-12-15
JP2022552187A5 JP2022552187A5 (https=) 2023-10-18

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JP2022520908A Pending JP2022552187A (ja) 2019-10-10 2020-10-09 選択的カリウムチャネルモジュレータの固体状態結晶形

Country Status (30)

Country Link
US (4) US11091441B2 (https=)
EP (2) EP4523687A3 (https=)
JP (1) JP2022552187A (https=)
KR (1) KR20220080119A (https=)
CN (4) CN119100981A (https=)
AU (1) AU2020364142A1 (https=)
BR (1) BR112022006583A2 (https=)
CA (1) CA3153752A1 (https=)
CL (1) CL2022000881A1 (https=)
CO (1) CO2022005890A2 (https=)
CR (1) CR20220187A (https=)
DK (1) DK4041713T3 (https=)
ES (1) ES3014703T3 (https=)
FI (1) FI4041713T3 (https=)
GE (2) GEP20247689B (https=)
HR (1) HRP20250134T1 (https=)
HU (1) HUE070295T2 (https=)
IL (2) IL292005B2 (https=)
LT (1) LT4041713T (https=)
MA (2) MA56288A1 (https=)
MX (3) MX2022004209A (https=)
PE (1) PE20221023A1 (https=)
PH (1) PH12022550854A1 (https=)
PL (1) PL4041713T3 (https=)
PT (1) PT4041713T (https=)
RS (1) RS66531B1 (https=)
SI (1) SI4041713T1 (https=)
SM (1) SMT202500101T1 (https=)
TW (1) TWI886158B (https=)
WO (1) WO2021072307A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI886158B (zh) * 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia
CA3151863C (en) 2021-10-27 2024-01-02 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
CN120441482A (zh) * 2024-02-08 2025-08-08 上海挚盟医药科技有限公司 四氢异喹啉基化合物的晶型及其应用
WO2025179128A1 (en) 2024-02-22 2025-08-28 Xenon Pharmaceuticals Inc. Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501568A (ja) * 2006-08-23 2010-01-21 バレアント ファーマシューティカルズ インターナショナル カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体
JP2011052022A (ja) * 2010-12-15 2011-03-17 Xenon Pharmaceuticals Inc 治療薬としてのニコチンアミド誘導体およびそれらの使用
JP2013518815A (ja) * 2010-02-01 2013-05-23 バレアント ファーマシューティカルズ インターナショナル カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体

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