CA3153752A1 - Solid state crystalline forms of a selective potassium channel modulator - Google Patents

Solid state crystalline forms of a selective potassium channel modulator Download PDF

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Publication number
CA3153752A1
CA3153752A1 CA3153752A CA3153752A CA3153752A1 CA 3153752 A1 CA3153752 A1 CA 3153752A1 CA 3153752 A CA3153752 A CA 3153752A CA 3153752 A CA3153752 A CA 3153752A CA 3153752 A1 CA3153752 A1 CA 3153752A1
Authority
CA
Canada
Prior art keywords
compound
solid state
degrees
composition
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3153752A
Other languages
English (en)
French (fr)
Inventor
Paul Robert BICHLER
Jean-Jacques Cadieux
Matthew David Tandy
Gregory N. Beatch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of CA3153752A1 publication Critical patent/CA3153752A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Liquid Crystal Substances (AREA)
  • Transmitters (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
CA3153752A 2019-10-10 2020-10-09 Solid state crystalline forms of a selective potassium channel modulator Pending CA3153752A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962913574P 2019-10-10 2019-10-10
US62/913,574 2019-10-10
PCT/US2020/055129 WO2021072307A1 (en) 2019-10-10 2020-10-09 Solid state crystalline forms of a selective potassium channel modulator

Publications (1)

Publication Number Publication Date
CA3153752A1 true CA3153752A1 (en) 2021-04-15

Family

ID=73040296

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3153752A Pending CA3153752A1 (en) 2019-10-10 2020-10-09 Solid state crystalline forms of a selective potassium channel modulator

Country Status (30)

Country Link
US (4) US11091441B2 (https=)
EP (2) EP4523687A3 (https=)
JP (1) JP2022552187A (https=)
KR (1) KR20220080119A (https=)
CN (4) CN119100981A (https=)
AU (1) AU2020364142A1 (https=)
BR (1) BR112022006583A2 (https=)
CA (1) CA3153752A1 (https=)
CL (1) CL2022000881A1 (https=)
CO (1) CO2022005890A2 (https=)
CR (1) CR20220187A (https=)
DK (1) DK4041713T3 (https=)
ES (1) ES3014703T3 (https=)
FI (1) FI4041713T3 (https=)
GE (2) GEP20247689B (https=)
HR (1) HRP20250134T1 (https=)
HU (1) HUE070295T2 (https=)
IL (2) IL292005B2 (https=)
LT (1) LT4041713T (https=)
MA (2) MA56288A1 (https=)
MX (3) MX2022004209A (https=)
PE (1) PE20221023A1 (https=)
PH (1) PH12022550854A1 (https=)
PL (1) PL4041713T3 (https=)
PT (1) PT4041713T (https=)
RS (1) RS66531B1 (https=)
SI (1) SI4041713T1 (https=)
SM (1) SMT202500101T1 (https=)
TW (1) TWI886158B (https=)
WO (1) WO2021072307A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI886158B (zh) * 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia
CA3151863C (en) 2021-10-27 2024-01-02 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
CN120441482A (zh) * 2024-02-08 2025-08-08 上海挚盟医药科技有限公司 四氢异喹啉基化合物的晶型及其应用
WO2025179128A1 (en) 2024-02-22 2025-08-28 Xenon Pharmaceuticals Inc. Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects

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Also Published As

Publication number Publication date
BR112022006583A2 (pt) 2022-06-28
PE20221023A1 (es) 2022-06-16
PL4041713T3 (pl) 2025-04-14
CN119100981A (zh) 2024-12-10
MA65149A1 (fr) 2026-03-31
MX2025010194A (es) 2025-10-01
EP4523687A3 (en) 2025-05-21
SI4041713T1 (sl) 2025-07-31
HUE070295T2 (hu) 2025-05-28
ES3014703T3 (en) 2025-04-24
CN120157617A (zh) 2025-06-17
RS66531B1 (sr) 2025-03-31
IL292005A (en) 2022-06-01
US20220064120A1 (en) 2022-03-03
US20240279182A1 (en) 2024-08-22
SMT202500101T1 (it) 2025-05-12
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