|
US5436A
(en)
|
|
1848-02-08 |
|
Air-heating furnace |
|
US150A
(en)
|
|
1837-03-25 |
|
Island |
|
CA197574A
(en)
|
|
1920-02-24 |
The Wirebounds Patents Company |
Wirebound box machine
|
|
US4714680B1
(en)
|
1984-02-06 |
1995-06-27 |
Univ Johns Hopkins |
Human stem cells
|
|
US4965204A
(en)
|
1984-02-06 |
1990-10-23 |
The Johns Hopkins University |
Human stem cells and monoclonal antibodies
|
|
JP2528107B2
(ja)
|
1985-03-15 |
1996-08-28 |
サマ−トン，ジエ−ムス |
ポリヌクレオチド測定試薬と方法
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US5422251A
(en)
|
1986-11-26 |
1995-06-06 |
Princeton University |
Triple-stranded nucleic acids
|
|
US4812397A
(en)
|
1987-02-10 |
1989-03-14 |
The Regents Of The University Of California |
MAB-anti-DNA related to nephritis
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US6441130B1
(en)
|
1991-05-24 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Linked peptide nucleic acids
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5487994A
(en)
|
1992-04-03 |
1996-01-30 |
The Johns Hopkins University |
Insertion and deletion mutants of FokI restriction endonuclease
|
|
US5436150A
(en)
|
1992-04-03 |
1995-07-25 |
The Johns Hopkins University |
Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
|
|
US5356802A
(en)
|
1992-04-03 |
1994-10-18 |
The Johns Hopkins University |
Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
|
|
CA2166079C
(en)
|
1993-06-25 |
2009-11-17 |
Peter Glazer |
Chemically modified oligonucleotide for site-directed mutagenesis
|
|
US5962426A
(en)
|
1993-06-25 |
1999-10-05 |
Yale University |
Triple-helix forming oligonucleotides for targeted mutagenesis
|
|
US5527675A
(en)
|
1993-08-20 |
1996-06-18 |
Millipore Corporation |
Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
|
|
DE4331012A1
(de)
|
1993-09-13 |
1995-03-16 |
Bayer Ag |
Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
|
|
US5409813A
(en)
|
1993-09-30 |
1995-04-25 |
Systemix, Inc. |
Method for mammalian cell separation from a mixture of cell populations
|
|
US5677136A
(en)
|
1994-11-14 |
1997-10-14 |
Systemix, Inc. |
Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
|
|
WO1996039195A2
(en)
|
1995-06-06 |
1996-12-12 |
Yale University |
Chemically modified oligonucleotide for site-directed mutagenesis
|
|
WO1996040271A1
(en)
|
1995-06-07 |
1996-12-19 |
Yale University |
Treatment of hemoglobinopathies
|
|
US7279463B2
(en)
|
1995-06-07 |
2007-10-09 |
Yale University |
Triple-helix forming oligonucleotides for targeted mutagenesis
|
|
WO1997032602A1
(en)
*
|
1996-03-08 |
1997-09-12 |
The Regents Of The University Of California |
DELIVERY SYSTEM USING mAb 3E10 AND MUTANTS AND/OR FUNCTIONAL FRAGMENTS THEREOF
|
|
US5945337A
(en)
|
1996-10-18 |
1999-08-31 |
Quality Biological, Inc. |
Method for culturing CD34+ cells in a serum-free medium
|
|
US5786571A
(en)
|
1997-05-09 |
1998-07-28 |
Lexmark International, Inc. |
Wrapped temperature sensing assembly
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
AU5886000A
(en)
|
1999-06-25 |
2001-01-31 |
Northwestern University |
Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells
|
|
US6919208B2
(en)
|
2000-05-22 |
2005-07-19 |
The Children's Hospital Of Philadelphia |
Methods and compositions for enhancing the delivery of a nucleic acid to a cell
|
|
CN100523215C
(zh)
|
2000-12-01 |
2009-08-05 |
马普科技促进协会 |
介导rna干涉的小rna分子
|
|
US7067617B2
(en)
|
2001-02-21 |
2006-06-27 |
The Scripps Research Institute |
Zinc finger binding domains for nucleotide sequence ANN
|
|
US20040197892A1
(en)
|
2001-04-04 |
2004-10-07 |
Michael Moore |
Composition binding polypeptides
|
|
WO2002094983A2
(en)
|
2001-05-16 |
2002-11-28 |
The Children's Hospital Of Philadelphia |
Dna-antibody complexes to enhance gene transfer
|
|
US20040224385A1
(en)
|
2001-08-20 |
2004-11-11 |
Barbas Carlos F |
Zinc finger binding domains for cnn
|
|
AU2002363997A1
(en)
|
2001-12-14 |
2003-06-30 |
Yale University |
Intracellular generation of single-stranded dna
|
|
DE102004042546A1
(de)
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
US20070036773A1
(en)
*
|
2005-08-09 |
2007-02-15 |
City Of Hope |
Generation and application of universal T cells for B-ALL
|
|
US8658608B2
(en)
|
2005-11-23 |
2014-02-25 |
Yale University |
Modified triple-helix forming oligonucleotides for targeted mutagenesis
|
|
CA2631422A1
(en)
|
2005-11-28 |
2007-05-31 |
The Scripps Research Institute |
Zinc finger binding domains for tnn
|
|
US20070154989A1
(en)
|
2006-01-03 |
2007-07-05 |
The Scripps Research Institute |
Zinc finger domains specifically binding agc
|
|
CN1986792A
(zh)
|
2006-12-14 |
2007-06-27 |
方炳良 |
致病细胞的外来抗原标记方法
|
|
US20100172882A1
(en)
|
2007-01-11 |
2010-07-08 |
Glazer Peter M |
Compositions and methods for targeted inactivation of hiv cell surface receptors
|
|
AU2008207948A1
(en)
|
2007-01-22 |
2008-07-31 |
The United States Government As Represented By The Department Of Veterans Affairs |
Use of antibody conjugates
|
|
JP2010527618A
(ja)
|
2007-05-24 |
2010-08-19 |
アメリカ合衆国 |
ヌクレオシドサルベージ経路を通しての核内タンパク質伝達
|
|
CA2777486A1
(en)
*
|
2008-10-15 |
2010-04-22 |
4S3 Bioscience Inc. |
Methods and compositions for treatment of myotonic dystrophy
|
|
US8309356B2
(en)
|
2009-04-01 |
2012-11-13 |
Yale University |
Pseudocomplementary oligonucleotides for targeted gene therapy
|
|
WO2010123983A1
(en)
|
2009-04-21 |
2010-10-28 |
Yale University |
Compostions and methods for targeted gene therapy
|
|
US9155801B2
(en)
*
|
2009-05-28 |
2015-10-13 |
The United States Government As Represented By The Department Of Veterans Affairs |
Amino acid sequences which enhance peptide conjugate solubility
|
|
AU2010260145B2
(en)
|
2009-06-15 |
2015-08-20 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of Myotubular Myopathy using chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides
|
|
US20110268810A1
(en)
|
2009-11-02 |
2011-11-03 |
Yale University |
Polymeric materials loaded with mutagenic and recombinagenic nucleic acids
|
|
PT2816112T
(pt)
|
2009-12-10 |
2018-11-20 |
Univ Iowa State Res Found Inc |
Modificação do adn modificada pelo efector tal
|
|
US20110293585A1
(en)
|
2010-04-21 |
2011-12-01 |
Helix Therapeutics, Inc. |
Compositions and methods for treatment of lysosomal storage disorders
|
|
US20110262406A1
(en)
|
2010-04-21 |
2011-10-27 |
Yale University |
Compositions and methods for targeted inactivation of hiv cell surface receptors
|
|
JP6178785B2
(ja)
|
2011-04-01 |
2017-08-09 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ |
細胞浸透性抗ｄｎａ抗体およびｄｎａ修復を阻害するためのその使用
|
|
EP2694640B1
(en)
|
2011-04-08 |
2017-10-18 |
Baylor College Of Medicine |
Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
|
|
EP3428287B1
(en)
|
2011-04-08 |
2021-03-24 |
Carnegie Mellon University |
Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids
|
|
US20130071414A1
(en)
|
2011-04-27 |
2013-03-21 |
Gianpietro Dotti |
Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
|
|
US9272043B2
(en)
|
2011-12-02 |
2016-03-01 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
|
WO2013082529A1
(en)
|
2011-12-02 |
2013-06-06 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
|
US9610362B2
(en)
|
2012-03-16 |
2017-04-04 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of DMPK
|
|
US9732146B2
(en)
|
2012-03-30 |
2017-08-15 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Antibody-mediated transduction of heat shock proteins into living cells
|
|
US9283272B2
(en)
|
2012-03-30 |
2016-03-15 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Targeting intracellular target-binding determinants with intracellular antibodies
|
|
ES2728782T3
(es)
|
2012-05-25 |
2019-10-28 |
Univ California |
Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN
|
|
MX382772B
(es)
|
2012-07-13 |
2025-03-11 |
Univ Pennsylvania |
Composición para usarse para prevenir o retardar el rechazo de trasplante de un tejido u órgano trasplantado en un sujeto.
|
|
CN116622704A
(zh)
|
2012-07-25 |
2023-08-22 |
布罗德研究所有限公司 |
可诱导的dna结合蛋白和基因组干扰工具及其应用
|
|
JP2016514096A
(ja)
|
2013-02-20 |
2016-05-19 |
バレリオン セラピューティクス， エルエルシー |
ポンぺ病の処置のための方法および組成物
|
|
WO2014201378A1
(en)
|
2013-06-13 |
2014-12-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy
|
|
WO2015106290A1
(en)
|
2014-01-13 |
2015-07-16 |
Valerion Therapeutics, Llc |
Internalizing moieties
|
|
WO2015134607A1
(en)
|
2014-03-04 |
2015-09-11 |
Yale University |
Cell penetrating anti-guanosine antibody based therapy for cancers with ras mutations
|
|
US10612041B2
(en)
|
2014-03-21 |
2020-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing without nucleases
|
|
SG10202109752XA
(en)
|
2014-04-07 |
2021-10-28 |
Novartis Ag |
Treatment of cancer using anti-cd19 chimeric antigen receptor
|
|
EP3154570A4
(en)
|
2014-06-13 |
2017-12-27 |
Valerion Therapeutics, LLC |
Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders
|
|
CA2995673A1
(en)
|
2014-08-27 |
2016-03-03 |
Valerion Therapeutics, Llc |
Internalizing moieties for treatment of cancer
|
|
JP2017534571A
(ja)
|
2014-08-28 |
2017-11-24 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ |
抗体３ｅ１０の多価フラグメントおよびその使用方法
|
|
WO2016081621A1
(en)
|
2014-11-18 |
2016-05-26 |
Yale University |
Formulations for targeted release of agents under low ph conditions and methods of use thereof
|
|
WO2017015101A1
(en)
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
|
US20190119357A1
(en)
|
2015-07-23 |
2019-04-25 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
WO2017109177A1
(en)
|
2015-12-24 |
2017-06-29 |
Selexis S.A. |
Improved eukaryotic cells for protein manufacturing and methods of making them
|
|
AU2017221424A1
(en)
|
2016-02-16 |
2018-09-20 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
|
JP2019508037A
(ja)
|
2016-02-16 |
2019-03-28 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ |
標的化遺伝子編集を増強するための組成物およびその使用方法
|
|
KR102775461B1
(ko)
*
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
EP3471777A1
(en)
*
|
2016-06-15 |
2019-04-24 |
Yale University |
Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors
|
|
WO2018187493A1
(en)
|
2017-04-04 |
2018-10-11 |
Yale University |
Compositions and methods for in utero delivery
|
|
US11613590B2
(en)
|
2017-07-17 |
2023-03-28 |
Nucleus Therapeutics Pty. Ltd |
Binding proteins 1
|
|
JP7395483B2
(ja)
|
2017-10-16 |
2023-12-11 |
アーディジェン， エルエルシー |
ｍＲＮＡの細胞内送達のためのペプチドおよびナノ粒子
|
|
US20210137960A1
(en)
|
2018-02-01 |
2021-05-13 |
Yale University |
Compositions and methods for inhibition of nuclear-penetrating antibodies
|
|
US12304970B2
(en)
|
2018-02-01 |
2025-05-20 |
Yale University |
Nuclear localization signals, compositions formed therefrom, and methods of use thereof for delivery of cargo to the nucleus
|
|
EP3844287B1
(en)
|
2018-08-31 |
2024-05-22 |
Yale University |
Compositions and methods for enhancing donor oligonucleotide-based gene editing
|
|
BR112021003823A2
(pt)
|
2018-08-31 |
2021-05-25 |
Yale University |
composição, composição farmacêutica e método para modificar o genoma de uma célula
|
|
FI20186112A1
(en)
|
2018-12-19 |
2020-06-20 |
Actim Oy |
System and method for analysing a point-of-care test result
|
|
KR20220101073A
(ko)
|
2019-08-30 |
2022-07-19 |
예일 유니버시티 |
핵산을 세포로 전달하기 위한 조성물 및 방법
|
|
CN111218458B
(zh)
|
2020-02-27 |
2020-11-20 |
珠海丽凡达生物技术有限公司 |
编码SARS-CoV-2病毒抗原的mRNA和疫苗及疫苗的制备方法
|
|
WO2022047424A1
(en)
|
2020-08-31 |
2022-03-03 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
AU2021390561A1
(en)
|
2020-12-04 |
2023-06-22 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
AU2023228912A1
(en)
|
2022-03-03 |
2024-09-19 |
Yale University |
Humanized 3e10 antibodies, variants, and antigen binding fragments thereof
|