|
US4714680B1
(en)
|
1984-02-06 |
1995-06-27 |
Univ Johns Hopkins |
Human stem cells
|
|
US4965204A
(en)
|
1984-02-06 |
1990-10-23 |
The Johns Hopkins University |
Human stem cells and monoclonal antibodies
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
WO1986005519A1
(en)
|
1985-03-15 |
1986-09-25 |
James Summerton |
Polynucleotide assay reagent and method
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US5422251A
(en)
|
1986-11-26 |
1995-06-06 |
Princeton University |
Triple-stranded nucleic acids
|
|
US4812397A
(en)
|
1987-02-10 |
1989-03-14 |
The Regents Of The University Of California |
MAB-anti-DNA related to nephritis
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US6441130B1
(en)
|
1991-05-24 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Linked peptide nucleic acids
|
|
US5436150A
(en)
|
1992-04-03 |
1995-07-25 |
The Johns Hopkins University |
Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
|
|
US5487994A
(en)
|
1992-04-03 |
1996-01-30 |
The Johns Hopkins University |
Insertion and deletion mutants of FokI restriction endonuclease
|
|
US5356802A
(en)
|
1992-04-03 |
1994-10-18 |
The Johns Hopkins University |
Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
|
|
ATE161541T1
(de)
|
1993-06-25 |
1998-01-15 |
Univ Yale |
Chemische-modifizierte oligonukleotide für site- spezifisches mutagenesis
|
|
US5962426A
(en)
|
1993-06-25 |
1999-10-05 |
Yale University |
Triple-helix forming oligonucleotides for targeted mutagenesis
|
|
US5527675A
(en)
|
1993-08-20 |
1996-06-18 |
Millipore Corporation |
Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
|
|
DE4331012A1
(de)
|
1993-09-13 |
1995-03-16 |
Bayer Ag |
Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
|
|
US5409813A
(en)
|
1993-09-30 |
1995-04-25 |
Systemix, Inc. |
Method for mammalian cell separation from a mixture of cell populations
|
|
US5677136A
(en)
|
1994-11-14 |
1997-10-14 |
Systemix, Inc. |
Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
|
|
AU6043296A
(en)
|
1995-06-06 |
1996-12-24 |
Yale University |
Chemically modified oligonucleotide for site-directed mutage nesis
|
|
WO1996040271A1
(en)
|
1995-06-07 |
1996-12-19 |
Yale University |
Treatment of hemoglobinopathies
|
|
US7279463B2
(en)
|
1995-06-07 |
2007-10-09 |
Yale University |
Triple-helix forming oligonucleotides for targeted mutagenesis
|
|
JP2000507225A
(ja)
*
|
1996-03-08 |
2000-06-13 |
ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア |
ｍａｂ ３Ｅ１０ ならびにその突然変異体および／または機能性フラグメントを使用する送達システム
|
|
US5945337A
(en)
|
1996-10-18 |
1999-08-31 |
Quality Biological, Inc. |
Method for culturing CD34+ cells in a serum-free medium
|
|
US5786571A
(en)
|
1997-05-09 |
1998-07-28 |
Lexmark International, Inc. |
Wrapped temperature sensing assembly
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6261841B1
(en)
|
1999-06-25 |
2001-07-17 |
The Board Of Trustees Of Northwestern University |
Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells
|
|
US6919208B2
(en)
|
2000-05-22 |
2005-07-19 |
The Children's Hospital Of Philadelphia |
Methods and compositions for enhancing the delivery of a nucleic acid to a cell
|
|
CA2429814C
(en)
|
2000-12-01 |
2014-02-18 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
US7067617B2
(en)
|
2001-02-21 |
2006-06-27 |
The Scripps Research Institute |
Zinc finger binding domains for nucleotide sequence ANN
|
|
US20040197892A1
(en)
|
2001-04-04 |
2004-10-07 |
Michael Moore |
Composition binding polypeptides
|
|
AU2002309567A1
(en)
|
2001-05-16 |
2002-12-03 |
The Children's Hospital Of Philadelphia |
Dna-antibody complexes to enhance gene transfer
|
|
JP2005500061A
(ja)
|
2001-08-20 |
2005-01-06 |
ザ スクリップス リサーチ インスティテュート |
Ｃｎｎについての亜鉛フィンガー結合ドメイン
|
|
IL162462A0
(en)
|
2001-12-14 |
2005-11-20 |
Univ Yale |
Intracellular generation of single-stranded dna
|
|
DE102004042546A1
(de)
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
US20070036773A1
(en)
*
|
2005-08-09 |
2007-02-15 |
City Of Hope |
Generation and application of universal T cells for B-ALL
|
|
US8658608B2
(en)
|
2005-11-23 |
2014-02-25 |
Yale University |
Modified triple-helix forming oligonucleotides for targeted mutagenesis
|
|
EP1963499A4
(en)
|
2005-11-28 |
2009-04-08 |
Scripps Research Inst |
ZINCFINGER BINDING DOMAIN FOR TNN
|
|
US20070154989A1
(en)
|
2006-01-03 |
2007-07-05 |
The Scripps Research Institute |
Zinc finger domains specifically binding agc
|
|
CN1986792A
(zh)
|
2006-12-14 |
2007-06-27 |
方炳良 |
致病细胞的外来抗原标记方法
|
|
WO2008086529A2
(en)
|
2007-01-11 |
2008-07-17 |
Yale University |
Compositions and methods for targeted inactivation of hiv cell surface receptors
|
|
AU2008207948A1
(en)
|
2007-01-22 |
2008-07-31 |
The United States Government As Represented By The Department Of Veterans Affairs |
Use of antibody conjugates
|
|
EP3486653A1
(en)
|
2007-05-24 |
2019-05-22 |
The United States Government as represented by The Department of Veterans Affairs |
Treatment of skeletal muscle disorder using ent2
|
|
WO2010044894A1
(en)
*
|
2008-10-15 |
2010-04-22 |
4S3 Bioscience Inc. |
Methods and compositions for treatment of myotonic dystrophy
|
|
US8309356B2
(en)
|
2009-04-01 |
2012-11-13 |
Yale University |
Pseudocomplementary oligonucleotides for targeted gene therapy
|
|
WO2010123983A1
(en)
|
2009-04-21 |
2010-10-28 |
Yale University |
Compostions and methods for targeted gene therapy
|
|
US9155801B2
(en)
*
|
2009-05-28 |
2015-10-13 |
The United States Government As Represented By The Department Of Veterans Affairs |
Amino acid sequences which enhance peptide conjugate solubility
|
|
AU2010260145B2
(en)
|
2009-06-15 |
2015-08-20 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of Myotubular Myopathy using chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides
|
|
US20110268810A1
(en)
|
2009-11-02 |
2011-11-03 |
Yale University |
Polymeric materials loaded with mutagenic and recombinagenic nucleic acids
|
|
WO2011072246A2
(en)
|
2009-12-10 |
2011-06-16 |
Regents Of The University Of Minnesota |
Tal effector-mediated dna modification
|
|
US20110293585A1
(en)
|
2010-04-21 |
2011-12-01 |
Helix Therapeutics, Inc. |
Compositions and methods for treatment of lysosomal storage disorders
|
|
US20110262406A1
(en)
|
2010-04-21 |
2011-10-27 |
Yale University |
Compositions and methods for targeted inactivation of hiv cell surface receptors
|
|
JP6178785B2
(ja)
*
|
2011-04-01 |
2017-08-09 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ |
細胞浸透性抗ｄｎａ抗体およびｄｎａ修復を阻害するためのその使用
|
|
CA2832569A1
(en)
|
2011-04-08 |
2012-10-11 |
Baylor College Of Medicine |
Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
|
|
WO2012138955A2
(en)
|
2011-04-08 |
2012-10-11 |
Ly Danith H |
CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS
|
|
US20130071414A1
(en)
|
2011-04-27 |
2013-03-21 |
Gianpietro Dotti |
Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
|
|
US9272043B2
(en)
|
2011-12-02 |
2016-03-01 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
|
WO2013082529A1
(en)
|
2011-12-02 |
2013-06-06 |
Yale University |
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
|
|
CA2907072A1
(en)
|
2012-03-16 |
2013-09-19 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of dmpk
|
|
US9283272B2
(en)
|
2012-03-30 |
2016-03-15 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Targeting intracellular target-binding determinants with intracellular antibodies
|
|
US9732146B2
(en)
|
2012-03-30 |
2017-08-15 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Antibody-mediated transduction of heat shock proteins into living cells
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
US20150290244A1
(en)
|
2012-07-13 |
2015-10-15 |
The Trustees Of The University Of Pennsylvania |
Use of cart19 to deplete normal b cells to induce tolerance
|
|
AU2013293270B2
(en)
|
2012-07-25 |
2018-08-16 |
Massachusetts Institute Of Technology |
Inducible DNA binding proteins and genome perturbation tools and applications thereof
|
|
AU2014218854B2
(en)
|
2013-02-20 |
2019-01-24 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of Pompe disease
|
|
US20150017120A1
(en)
|
2013-06-13 |
2015-01-15 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il-2 and adoptive cell therapy
|
|
AU2015204446A1
(en)
|
2014-01-13 |
2016-07-14 |
Valerion Therapeutics, Llc |
Internalizing moieties
|
|
US10040867B2
(en)
|
2014-03-04 |
2018-08-07 |
Yale University |
Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations
|
|
BR112016019940A2
(pt)
|
2014-03-21 |
2017-10-24 |
Univ Leland Stanford Junior |
edição de genoma sem nucleases
|
|
AU2015244039B2
(en)
|
2014-04-07 |
2021-10-21 |
Novartis Ag |
Treatment of cancer using anti-CD19 chimeric antigen receptor
|
|
WO2015192092A1
(en)
|
2014-06-13 |
2015-12-17 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders
|
|
CA2995673A1
(en)
|
2014-08-27 |
2016-03-03 |
Valerion Therapeutics, Llc |
Internalizing moieties for treatment of cancer
|
|
WO2016033321A1
(en)
|
2014-08-28 |
2016-03-03 |
Yale University |
Multivalent fragments of antibody 3e10 and methods of use thereof
|
|
WO2016081621A1
(en)
|
2014-11-18 |
2016-05-26 |
Yale University |
Formulations for targeted release of agents under low ph conditions and methods of use thereof
|
|
WO2017015101A1
(en)
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
|
EP3325505B1
(en)
|
2015-07-23 |
2020-08-19 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
IL259221B
(en)
|
2015-12-24 |
2022-09-01 |
Selexis Sa |
Improved eukaryotic cells for protein production and methods for their production
|
|
US20200308590A1
(en)
|
2016-02-16 |
2020-10-01 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
|
JP2019508037A
(ja)
|
2016-02-16 |
2019-03-28 |
イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ |
標的化遺伝子編集を増強するための組成物およびその使用方法
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
EP3471777A1
(en)
*
|
2016-06-15 |
2019-04-24 |
Yale University |
Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors
|
|
WO2018187493A1
(en)
|
2017-04-04 |
2018-10-11 |
Yale University |
Compositions and methods for in utero delivery
|
|
EP3655432A4
(en)
|
2017-07-17 |
2021-04-14 |
Nucleus Therapeutics Pty Ltd |
BINDING PROTEINS 1
|
|
AU2018352221B2
(en)
|
2017-10-16 |
2024-04-18 |
Aadigen, Llc |
Peptides and nanoparticles for intracellular delivery of mRNA
|
|
US20210137960A1
(en)
|
2018-02-01 |
2021-05-13 |
Yale University |
Compositions and methods for inhibition of nuclear-penetrating antibodies
|
|
WO2019152806A1
(en)
|
2018-02-01 |
2019-08-08 |
Yale University |
Compositions and methods for enhancing nuclear translocation
|
|
EP3844287B1
(en)
|
2018-08-31 |
2024-05-22 |
Yale University |
Compositions and methods for enhancing donor oligonucleotide-based gene editing
|
|
CA3111186A1
(en)
|
2018-08-31 |
2020-03-05 |
Yale University |
Compositions and methods for enhancing triplex and nuclease-based gene editing
|
|
FI20186112A1
(en)
|
2018-12-19 |
2020-06-20 |
Actim Oy |
System and method for analysing a point-of-care test result
|
|
WO2021042060A1
(en)
|
2019-08-30 |
2021-03-04 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
CN111218458B
(zh)
|
2020-02-27 |
2020-11-20 |
珠海丽凡达生物技术有限公司 |
编码SARS-CoV-2病毒抗原的mRNA和疫苗及疫苗的制备方法
|
|
CN116529266A
(zh)
|
2020-08-31 |
2023-08-01 |
耶鲁大学 |
用于将核酸递送到细胞的组合物和方法
|
|
AU2021390561A1
(en)
|
2020-12-04 |
2023-06-22 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
US20230303719A1
(en)
|
2022-03-03 |
2023-09-28 |
Yale University |
Humanized 3e10 antibodies, variants, and antigen binding fragments thereof
|