JP2022545159A5 - - Google Patents
Info
- Publication number
- JP2022545159A5 JP2022545159A5 JP2022503834A JP2022503834A JP2022545159A5 JP 2022545159 A5 JP2022545159 A5 JP 2022545159A5 JP 2022503834 A JP2022503834 A JP 2022503834A JP 2022503834 A JP2022503834 A JP 2022503834A JP 2022545159 A5 JP2022545159 A5 JP 2022545159A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- independently selected
- heterocyclyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2019/052358 WO2021032935A1 (en) | 2019-08-21 | 2019-08-21 | Enzyme inhibitors |
| GBPCT/GB2019/052358 | 2019-08-21 | ||
| PCT/GB2020/050334 WO2021032938A1 (en) | 2019-08-21 | 2020-02-13 | Enzyme inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022545159A JP2022545159A (ja) | 2022-10-26 |
| JP2022545159A5 true JP2022545159A5 (https=) | 2023-02-20 |
Family
ID=67777358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022503834A Ceased JP2022545159A (ja) | 2019-08-21 | 2020-02-13 | 酵素阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220289727A1 (https=) |
| EP (1) | EP4017850A1 (https=) |
| JP (1) | JP2022545159A (https=) |
| KR (1) | KR20220050925A (https=) |
| CN (1) | CN114258392A (https=) |
| AR (1) | AR118083A1 (https=) |
| AU (1) | AU2020331720A1 (https=) |
| BR (1) | BR112022001390A2 (https=) |
| CA (1) | CA3148028A1 (https=) |
| CO (1) | CO2022000270A2 (https=) |
| IL (1) | IL289778A (https=) |
| MX (1) | MX2022000811A (https=) |
| PH (1) | PH12022550118A1 (https=) |
| TW (1) | TW202115021A (https=) |
| WO (2) | WO2021032935A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021032936A1 (en) * | 2019-08-21 | 2021-02-25 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| CN119264065A (zh) * | 2023-07-05 | 2025-01-07 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| AU778393B2 (en) * | 1999-05-12 | 2004-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| GB0518237D0 (en) * | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP2137158A4 (en) * | 2007-02-28 | 2012-04-18 | Methylgene Inc | LOW-MOLECULAR INHIBITORS OF PROTEINARGININE METHYLTRANSFERASES (PRMTS) |
| WO2009147188A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| EP2149552A1 (de) * | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| US9290485B2 (en) * | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| WO2012074703A1 (en) * | 2010-12-03 | 2012-06-07 | Allergan, Inc. | Novel azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators |
| US9352016B2 (en) | 2011-03-09 | 2016-05-31 | Csl Behring Gmbh | Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces |
| US8404859B2 (en) * | 2011-03-16 | 2013-03-26 | Hoffmann-La Roche Inc. | Thiazole and thiophene compounds |
| US20120252853A1 (en) * | 2011-04-01 | 2012-10-04 | H. Lundbeck A/S | Positive allosteric modulators of nicotinic acetylcholine receptor |
| BR112013026341A2 (pt) * | 2011-04-13 | 2019-09-24 | Merck Sharp & Dohe Corp | composto, composição farmacêutica, e, método para tratar, prevenir e/ou atrasar o início de uma doença ou patologia |
| WO2012144661A1 (en) * | 2011-04-20 | 2012-10-26 | Shionogi & Co., Ltd. | Aromatic heterocyclic derivative having trpv4-inhibiting activity |
| US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| AR088989A1 (es) * | 2011-11-30 | 2014-07-23 | Hoffmann La Roche | Derivados biciclicos de dihidroisoquinolin-1-ona |
| PE20150224A1 (es) * | 2012-05-11 | 2015-03-08 | Abbvie Inc | Inhibidores del nampt |
| GB201300304D0 (en) * | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
| EP2999697B1 (en) | 2013-05-23 | 2017-04-19 | Kalvista Pharmaceuticals Limited | Heterocyclic derivates |
| KR102736869B1 (ko) * | 2014-03-07 | 2024-12-02 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 인간 혈장 칼리크레인 저해제 |
| US10772881B2 (en) * | 2017-02-27 | 2020-09-15 | Russell Dahl | Quinolines that modulate SERCA and their use for treating disease |
| GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| CN104592204B (zh) * | 2014-12-26 | 2017-05-17 | 华润赛科药业有限责任公司 | 达比加群衍生物及其制备方法和用途 |
| WO2017123518A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Aminotriazole immunomodulators for treating autoimmune diseases |
| GB201604647D0 (en) * | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| US10759808B2 (en) * | 2016-04-06 | 2020-09-01 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| AU2017269256B2 (en) | 2016-05-23 | 2021-02-25 | The Rockefeller University | Aminoacylindazole immunomodulators for treatment of autoimmune diseases |
| US10858319B2 (en) * | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
| WO2018093716A1 (en) | 2016-11-18 | 2018-05-24 | Merck Sharp & Dohme Corp. | FACTOR XIIa INHIBITORS |
| EP3541375B1 (en) | 2016-11-18 | 2023-08-23 | Merck Sharp & Dohme LLC | Factor xiia inhibitors |
| EP3716972A4 (en) | 2017-11-29 | 2021-08-25 | The Rockefeller University | PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| CN112585119A (zh) * | 2018-08-14 | 2021-03-30 | Epizyme股份有限公司 | 经取代的吲哚及其使用方法 |
| EP4010333A1 (en) * | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021032936A1 (en) * | 2019-08-21 | 2021-02-25 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
-
2019
- 2019-08-21 WO PCT/GB2019/052358 patent/WO2021032935A1/en not_active Ceased
- 2019-08-21 EP EP19759702.4A patent/EP4017850A1/en not_active Withdrawn
- 2019-08-21 CN CN201980099443.1A patent/CN114258392A/zh active Pending
-
2020
- 2020-02-13 MX MX2022000811A patent/MX2022000811A/es unknown
- 2020-02-13 KR KR1020227008854A patent/KR20220050925A/ko not_active Withdrawn
- 2020-02-13 PH PH1/2022/550118A patent/PH12022550118A1/en unknown
- 2020-02-13 WO PCT/GB2020/050334 patent/WO2021032938A1/en not_active Ceased
- 2020-02-13 TW TW109104466A patent/TW202115021A/zh unknown
- 2020-02-13 US US17/634,593 patent/US20220289727A1/en active Pending
- 2020-02-13 CA CA3148028A patent/CA3148028A1/en active Pending
- 2020-02-13 AU AU2020331720A patent/AU2020331720A1/en active Pending
- 2020-02-13 JP JP2022503834A patent/JP2022545159A/ja not_active Ceased
- 2020-02-13 BR BR112022001390A patent/BR112022001390A2/pt not_active Application Discontinuation
- 2020-02-13 AR ARP200100397A patent/AR118083A1/es not_active Application Discontinuation
-
2022
- 2022-01-12 IL IL289778A patent/IL289778A/en unknown
- 2022-01-17 CO CONC2022/0000270A patent/CO2022000270A2/es unknown
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