JP2022544825A - 細胞免疫療法のためのリンパ球枯渇投与レジメン - Google Patents

細胞免疫療法のためのリンパ球枯渇投与レジメン Download PDF

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JP2022544825A
JP2022544825A JP2022510857A JP2022510857A JP2022544825A JP 2022544825 A JP2022544825 A JP 2022544825A JP 2022510857 A JP2022510857 A JP 2022510857A JP 2022510857 A JP2022510857 A JP 2022510857A JP 2022544825 A JP2022544825 A JP 2022544825A
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genetically modified
cells
administration
antibody
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JPWO2021035054A5 (https=
JP2022544825A5 (https=
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マクリーディ，ブルース，ジェイ．，ジュニア
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プレシジョン バイオサイエンシズ，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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JP2022510857A 2019-08-20 2020-08-20 細胞免疫療法のためのリンパ球枯渇投与レジメン Pending JP2022544825A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962889338P 2019-08-20 2019-08-20
US62/889,338 2019-08-20
US202063061070P 2020-08-04 2020-08-04
US63/061,070 2020-08-04
PCT/US2020/047202 WO2021035054A1 (en) 2019-08-20 2020-08-20 Lymphodepletion dosing regimens for cellular immunotherapies

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JP2022544825A true JP2022544825A (ja) 2022-10-21
JPWO2021035054A5 JPWO2021035054A5 (https=) 2023-08-29
JP2022544825A5 JP2022544825A5 (https=) 2023-08-29

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US (1) US20220273720A1 (https=)
EP (1) EP4017526A1 (https=)
JP (1) JP2022544825A (https=)
AU (1) AU2020333851A1 (https=)
CA (1) CA3148179A1 (https=)
WO (1) WO2021035054A1 (https=)

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