|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5359078A
(en)
|
1989-05-19 |
1994-10-25 |
The United States Of America As Represented By The Department Of Health And Human Services |
Signal transduction inhibitor compounds
|
|
US5225347A
(en)
|
1989-09-25 |
1993-07-06 |
Innovir Laboratories, Inc. |
Therapeutic ribozyme compositions and expression vectors
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5141851A
(en)
|
1990-04-18 |
1992-08-25 |
Board Of Regents, The University Of Texas System |
Isolated farnesyl protein transferase enzyme
|
|
US5420245A
(en)
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
|
US5401629A
(en)
|
1990-08-07 |
1995-03-28 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Assay methods and compositions useful for measuring the transduction of an intracellular signal
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
US5502224A
(en)
|
1991-06-04 |
1996-03-26 |
Marigen, S.A. |
Biotenside esters and phosphatides with vitamin-D and vitamin-E compounds
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5238922A
(en)
|
1991-09-30 |
1993-08-24 |
Merck & Co., Inc. |
Inhibitors of farnesyl protein transferase
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
CA2107644A1
(en)
|
1992-10-28 |
1994-04-29 |
David R. Magnin |
.alpha.-phosphonosulfonae squalene synthetase inhibitors and methd
|
|
AU6909194A
(en)
|
1993-05-14 |
1994-12-12 |
Board Of Regents, The University Of Texas System |
Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
|
|
US5602098A
(en)
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
|
US5834434A
(en)
|
1993-05-18 |
1998-11-10 |
University Of Pittsburgh |
Inhibitors of farnesyltransferase
|
|
US5705686A
(en)
|
1993-05-18 |
1998-01-06 |
University Of Pittsburgh |
Inhibition of farnesyl transferase
|
|
US6075025A
(en)
|
1993-10-15 |
2000-06-13 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US6365588B1
(en)
|
1993-10-15 |
2002-04-02 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US5470832A
(en)
|
1994-01-31 |
1995-11-28 |
Merck & Co., Inc. |
Inhibitors of geranylgeranyl-protein transferase
|
|
US5631401A
(en)
|
1994-02-09 |
1997-05-20 |
Abbott Laboratories |
Inhibitors of protein farnesyltransferase and squalene synthase
|
|
US5439918A
(en)
|
1994-03-14 |
1995-08-08 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5420334A
(en)
|
1994-04-04 |
1995-05-30 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5523430A
(en)
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
|
US5510510A
(en)
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US5447922A
(en)
|
1994-08-24 |
1995-09-05 |
Bristol-Myers Squibb Company |
α-phosphonosulfinic squalene synthetase inhibitors
|
|
US5830868A
(en)
|
1994-09-13 |
1998-11-03 |
Warner-Lambert Company |
Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
|
|
US5574025A
(en)
|
1994-10-26 |
1996-11-12 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferases
|
|
US5786193A
(en)
|
1995-01-11 |
1998-07-28 |
Human Genome Sciences, Inc. |
Human geranylgeranyl pyrophosphate synthethase
|
|
US5801175A
(en)
|
1995-04-07 |
1998-09-01 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5756528A
(en)
|
1995-06-06 |
1998-05-26 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5618964A
(en)
|
1995-06-07 |
1997-04-08 |
Bristol-Myers Squibb Company |
Prodrug esters of phosphonosulfonate squalene synthetase inhibitors and method
|
|
GB9604311D0
(en)
|
1996-02-29 |
1996-05-01 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase
|
|
IT1276162B1
(it)
|
1995-11-23 |
1997-10-27 |
Baldacci Lab Spa |
Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
|
|
US5874442A
(en)
|
1995-12-22 |
1999-02-23 |
Schering-Plough Corporation |
Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
|
|
US6011029A
(en)
|
1996-02-26 |
2000-01-04 |
Bristol-Myers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US5891889A
(en)
|
1996-04-03 |
1999-04-06 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5773455A
(en)
|
1996-06-28 |
1998-06-30 |
Biomeasure, Incorporated |
Inhibitors of prenyl transferases
|
|
US6030982A
(en)
|
1996-09-13 |
2000-02-29 |
Schering Corporationm |
Compounds useful for inhibition of farnesyl protein transferase
|
|
US5994364A
(en)
|
1996-09-13 |
1999-11-30 |
Schering Corporation |
Tricyclic antitumor farnesyl protein transferase inhibitors
|
|
US6083979A
(en)
|
1996-10-09 |
2000-07-04 |
University Of Pittsburgh |
Geranylgeraniol/lovastatin: a novel approach to blocking cancer transformation without cytotoxicity
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
US5929077A
(en)
|
1996-11-08 |
1999-07-27 |
Leftheris; Katerina |
Thioproline-containing inhibitors of farnesyl protein transferase
|
|
CA2722378C
(en)
|
1996-12-03 |
2015-02-03 |
Amgen Fremont Inc. |
Human antibodies that bind tnf.alpha.
|
|
US6265382B1
(en)
|
1997-04-11 |
2001-07-24 |
Warner-Lambert Company |
Dipeptide inhibitors of protein farnesyltransferase
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
US6051565A
(en)
|
1997-04-26 |
2000-04-18 |
International Phytochemistry Research Labs, Ltd. |
Farnesyl-protein transferase inhibitors
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6239140B1
(en)
|
1997-06-17 |
2001-05-29 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
|
US6358968B1
(en)
|
1997-06-17 |
2002-03-19 |
Schering Corporation |
N-substituted urea inhibitors of farnesyl-protein transferase
|
|
US6159984A
(en)
|
1997-06-17 |
2000-12-12 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
|
US6225322B1
(en)
|
1997-06-17 |
2001-05-01 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
|
US6576639B1
(en)
|
1997-06-17 |
2003-06-10 |
Schering Corporation |
Compounds for the inhibition of farnesyl protein transferase
|
|
US6228865B1
(en)
|
1997-06-17 |
2001-05-08 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
|
US6211193B1
(en)
|
1997-06-17 |
2001-04-03 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
|
US6426352B1
(en)
|
1997-06-17 |
2002-07-30 |
Schering Corporation |
Sulfonamide inhibitors of farnesyl-protein transferase
|
|
US6218401B1
(en)
|
1997-06-17 |
2001-04-17 |
Schering Corporation |
Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
|
|
TW527355B
(en)
|
1997-07-02 |
2003-04-11 |
Bristol Myers Squibb Co |
Inhibitors of farnesyl protein transferase
|
|
US6387903B1
(en)
|
1997-08-27 |
2002-05-14 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
|
US6458783B1
(en)
|
1997-09-29 |
2002-10-01 |
Bristol-Myers Squibb Company |
Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
|
|
WO1999026657A1
(en)
|
1997-11-25 |
1999-06-03 |
Musc Foundation For Research Development |
Inhibitors of nitric oxide synthase
|
|
US6267952B1
(en)
|
1998-01-09 |
2001-07-31 |
Geltex Pharmaceuticals, Inc. |
Lipase inhibiting polymers
|
|
US6586461B1
(en)
|
1998-06-16 |
2003-07-01 |
Wayne State University |
Prenyl transferase inhibitors
|
|
ID26987A
(id)
|
1998-07-06 |
2001-02-22 |
Janssen Pharmaceutica Nv |
Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
|
|
HRP20000904A2
(en)
|
1998-07-06 |
2001-12-31 |
Janssen Pharmaceutica Nv |
Farnesyl protein transferase inhibitors for treating arthropathies
|
|
US6423751B1
(en)
|
1998-07-14 |
2002-07-23 |
The Brigham And Women's Hospital, Inc. |
Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
|
|
US6539309B1
(en)
|
1998-07-30 |
2003-03-25 |
Schering Corporation |
Crystallizable farnesyl protein transferase compositions, crystals thereby obtained, and methods for use
|
|
DE19835850A1
(de)
|
1998-08-07 |
2000-02-10 |
Basf Ag |
Verwendung von Hemmstoffen der HMG-CoA-Reduktase zur Senkung des Cholesteringehaltes in Geflügelei
|
|
US6156746A
(en)
|
1998-08-25 |
2000-12-05 |
Bristol-Myers Squibb Company |
1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
|
|
ES2237125T3
(es)
|
1998-08-27 |
2005-07-16 |
Pfizer Products Inc. |
Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
|
|
ID27562A
(id)
|
1998-08-27 |
2001-04-12 |
Pfizer Prod Inc |
Turunan-turunan kinolin-2-ona tersubstitusi alkunil yang berguna sebagai zat anti kanker
|
|
US6535820B1
(en)
|
1998-08-28 |
2003-03-18 |
Schering Corporation |
Crystalline farnesyl protein transferase compositions and methods for use
|
|
US6329376B1
(en)
|
1998-10-29 |
2001-12-11 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
|
EP1006113A1
(en)
|
1998-12-02 |
2000-06-07 |
Pfizer Products Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
|
|
US6362188B1
(en)
|
1998-12-18 |
2002-03-26 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
|
US6372747B1
(en)
|
1998-12-18 |
2002-04-16 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
|
US6432959B1
(en)
|
1998-12-23 |
2002-08-13 |
Schering Corporation |
Inhibitors of farnesyl-protein transferase
|
|
US6191147B1
(en)
|
1998-12-24 |
2001-02-20 |
Ppd Discovery, Inc. |
Pyrazole compounds and uses thereof
|
|
PL349839A1
(en)
|
1999-02-11 |
2002-09-23 |
Pfizer Prod Inc |
Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
|
|
AU3386600A
(en)
|
1999-03-03 |
2000-09-21 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
|
US6586447B1
(en)
|
1999-04-01 |
2003-07-01 |
Pfizer Inc |
3,3-disubstituted-oxindole derivatives useful as anticancer agents
|
|
US6316462B1
(en)
|
1999-04-09 |
2001-11-13 |
Schering Corporation |
Methods of inducing cancer cell death and tumor regression
|
|
US6458935B1
(en)
|
1999-06-23 |
2002-10-01 |
Merck & Co., Inc. |
Radiolabeled farnesyl-protein transferase inhibitors
|
|
AU6098300A
(en)
|
1999-07-16 |
2001-02-05 |
Human Genome Sciences, Inc. |
Follistatin-3
|
|
WO2001018006A1
(en)
|
1999-09-09 |
2001-03-15 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
|
PT1106612E
(pt)
|
1999-11-30 |
2004-06-30 |
Pfizer Prod Inc |
Derivados de quinolina uteis para inibir a farnesil-proteina-transferase
|
|
US6403581B1
(en)
|
2000-01-19 |
2002-06-11 |
American Cyanamid Company |
Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
|
|
KR100372911B1
(ko)
|
2000-03-22 |
2003-02-17 |
한국생명공학연구원 |
파네실 전이효소의 저해 활성, 세포 주기의 조절 활성 및신생혈관유도 저해 활성을 갖는 9-아세틸아테미놀라이드화합물, 이의 분리 방법 및 이를 포함하는 약학 조성물
|
|
EP1337522B1
(en)
|
2000-11-29 |
2007-08-29 |
Schering Corporation |
farnesyl protein transferase inhibitors
|
|
CA2429814C
(en)
|
2000-12-01 |
2014-02-18 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
DE60310944T3
(de)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Weitere neue formen von interferierende rns moleküle
|
|
US6649638B1
(en)
|
2002-08-14 |
2003-11-18 |
Ppd Discovery, Inc. |
Prenylation inhibitors and methods of their synthesis and use
|
|
JP4691041B2
(ja)
*
|
2003-11-20 |
2011-06-01 |
チルドレンズ ホスピタル メディカル センター |
Gtpアーゼ阻害剤および使用方法
|
|
US8383124B2
(en)
*
|
2008-03-12 |
2013-02-26 |
Children's Hospital Medical Center |
Mobilization of hematopoietic stem cells
|
|
WO2010010027A1
(en)
*
|
2008-07-23 |
2010-01-28 |
Vib Vzw |
Antifungal compounds
|
|
JP6001650B2
(ja)
*
|
2011-05-23 |
2016-10-05 |
昂科生物医学技術(蘇州)有限公司 |
Cdc42抑制剤およびその応用
|
|
US9980942B2
(en)
*
|
2012-05-02 |
2018-05-29 |
Children's Hospital Medical Center |
Rejuvenation of precursor cells
|
|
WO2019140300A1
(en)
*
|
2018-01-11 |
2019-07-18 |
Fred Hutchinson Cancer Research Center |
Compositions and methods to promote thymic regeneration
|
|
WO2021011800A1
(en)
*
|
2019-07-17 |
2021-01-21 |
Children's Hospital Medical Center |
Method of treating neoplastic diseases with a cdc42-specific inhibitor
|