JP2022544579A5 - - Google Patents

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Publication number
JP2022544579A5
JP2022544579A5 JP2022509573A JP2022509573A JP2022544579A5 JP 2022544579 A5 JP2022544579 A5 JP 2022544579A5 JP 2022509573 A JP2022509573 A JP 2022509573A JP 2022509573 A JP2022509573 A JP 2022509573A JP 2022544579 A5 JP2022544579 A5 JP 2022544579A5
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JP
Japan
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alkyl
group
optionally substituted
alkoxy
fluoros
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JP2022509573A
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Japanese (ja)
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JP2022544579A (ja
JP7718659B2 (ja
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Priority claimed from PCT/US2020/046209 external-priority patent/WO2021034616A1/en
Publication of JP2022544579A publication Critical patent/JP2022544579A/ja
Publication of JP2022544579A5 publication Critical patent/JP2022544579A5/ja
Priority to JP2025092697A priority Critical patent/JP2025131688A/ja
Application granted granted Critical
Publication of JP7718659B2 publication Critical patent/JP7718659B2/ja
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JP2022509573A 2019-08-16 2020-08-13 Cdc42特異的阻害剤で対象を治療する方法 Active JP7718659B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025092697A JP2025131688A (ja) 2019-08-16 2025-06-03 Cdc42特異的阻害剤で対象を治療する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962888027P 2019-08-16 2019-08-16
US62/888,027 2019-08-16
PCT/US2020/046209 WO2021034616A1 (en) 2019-08-16 2020-08-13 Methods of treating a subject with a cdc42-specific inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025092697A Division JP2025131688A (ja) 2019-08-16 2025-06-03 Cdc42特異的阻害剤で対象を治療する方法

Publications (3)

Publication Number Publication Date
JP2022544579A JP2022544579A (ja) 2022-10-19
JP2022544579A5 true JP2022544579A5 (https=) 2023-09-21
JP7718659B2 JP7718659B2 (ja) 2025-08-05

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ID=74659682

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JP2022509573A Active JP7718659B2 (ja) 2019-08-16 2020-08-13 Cdc42特異的阻害剤で対象を治療する方法
JP2025092697A Pending JP2025131688A (ja) 2019-08-16 2025-06-03 Cdc42特異的阻害剤で対象を治療する方法

Family Applications After (1)

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JP2025092697A Pending JP2025131688A (ja) 2019-08-16 2025-06-03 Cdc42特異的阻害剤で対象を治療する方法

Country Status (6)

Country Link
US (1) US20220288197A1 (https=)
EP (2) EP4013402B1 (https=)
JP (2) JP7718659B2 (https=)
CN (1) CN114450027A (https=)
CA (1) CA3151110A1 (https=)
WO (1) WO2021034616A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025231227A1 (en) * 2024-05-03 2025-11-06 Mogling Bio Inc. New compounds for medical use

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5359078A (en) 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
US5225347A (en) 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Therapeutic ribozyme compositions and expression vectors
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5141851A (en) 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5420245A (en) 1990-04-18 1995-05-30 Board Of Regents, The University Of Texas Tetrapeptide-based inhibitors of farnesyl transferase
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5502224A (en) 1991-06-04 1996-03-26 Marigen, S.A. Biotenside esters and phosphatides with vitamin-D and vitamin-E compounds
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5238922A (en) 1991-09-30 1993-08-24 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
CA2107644A1 (en) 1992-10-28 1994-04-29 David R. Magnin .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd
AU6909194A (en) 1993-05-14 1994-12-12 Board Of Regents, The University Of Texas System Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
US5602098A (en) 1993-05-18 1997-02-11 University Of Pittsburgh Inhibition of farnesyltransferase
US5834434A (en) 1993-05-18 1998-11-10 University Of Pittsburgh Inhibitors of farnesyltransferase
US5705686A (en) 1993-05-18 1998-01-06 University Of Pittsburgh Inhibition of farnesyl transferase
US6075025A (en) 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5470832A (en) 1994-01-31 1995-11-28 Merck & Co., Inc. Inhibitors of geranylgeranyl-protein transferase
US5631401A (en) 1994-02-09 1997-05-20 Abbott Laboratories Inhibitors of protein farnesyltransferase and squalene synthase
US5439918A (en) 1994-03-14 1995-08-08 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5420334A (en) 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5523430A (en) 1994-04-14 1996-06-04 Bristol-Myers Squibb Company Protein farnesyl transferase inhibitors
US5510510A (en) 1994-05-10 1996-04-23 Bristol-Meyers Squibb Company Inhibitors of farnesyl protein transferase
US5447922A (en) 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
US5830868A (en) 1994-09-13 1998-11-03 Warner-Lambert Company Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
US5574025A (en) 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
US5786193A (en) 1995-01-11 1998-07-28 Human Genome Sciences, Inc. Human geranylgeranyl pyrophosphate synthethase
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5756528A (en) 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5618964A (en) 1995-06-07 1997-04-08 Bristol-Myers Squibb Company Prodrug esters of phosphonosulfonate squalene synthetase inhibitors and method
GB9604311D0 (en) 1996-02-29 1996-05-01 Merck & Co Inc Inhibitors of farnesyl-protein transferase
IT1276162B1 (it) 1995-11-23 1997-10-27 Baldacci Lab Spa Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US5891889A (en) 1996-04-03 1999-04-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5773455A (en) 1996-06-28 1998-06-30 Biomeasure, Incorporated Inhibitors of prenyl transferases
US6030982A (en) 1996-09-13 2000-02-29 Schering Corporationm Compounds useful for inhibition of farnesyl protein transferase
US5994364A (en) 1996-09-13 1999-11-30 Schering Corporation Tricyclic antitumor farnesyl protein transferase inhibitors
US6083979A (en) 1996-10-09 2000-07-04 University Of Pittsburgh Geranylgeraniol/lovastatin: a novel approach to blocking cancer transformation without cytotoxicity
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
US5929077A (en) 1996-11-08 1999-07-27 Leftheris; Katerina Thioproline-containing inhibitors of farnesyl protein transferase
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
US6265382B1 (en) 1997-04-11 2001-07-24 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
BRPI9809391B8 (pt) 1997-04-14 2021-05-25 Amgen Res Munich Gmbh processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
US6051565A (en) 1997-04-26 2000-04-18 International Phytochemistry Research Labs, Ltd. Farnesyl-protein transferase inhibitors
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6239140B1 (en) 1997-06-17 2001-05-29 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6358968B1 (en) 1997-06-17 2002-03-19 Schering Corporation N-substituted urea inhibitors of farnesyl-protein transferase
US6159984A (en) 1997-06-17 2000-12-12 Schering Corporation Farnesyl protein transferase inhibitors
US6225322B1 (en) 1997-06-17 2001-05-01 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6576639B1 (en) 1997-06-17 2003-06-10 Schering Corporation Compounds for the inhibition of farnesyl protein transferase
US6228865B1 (en) 1997-06-17 2001-05-08 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6211193B1 (en) 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6426352B1 (en) 1997-06-17 2002-07-30 Schering Corporation Sulfonamide inhibitors of farnesyl-protein transferase
US6218401B1 (en) 1997-06-17 2001-04-17 Schering Corporation Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
TW527355B (en) 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
US6387903B1 (en) 1997-08-27 2002-05-14 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6458783B1 (en) 1997-09-29 2002-10-01 Bristol-Myers Squibb Company Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
WO1999026657A1 (en) 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6586461B1 (en) 1998-06-16 2003-07-01 Wayne State University Prenyl transferase inhibitors
ID26987A (id) 1998-07-06 2001-02-22 Janssen Pharmaceutica Nv Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
HRP20000904A2 (en) 1998-07-06 2001-12-31 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating arthropathies
US6423751B1 (en) 1998-07-14 2002-07-23 The Brigham And Women's Hospital, Inc. Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
US6539309B1 (en) 1998-07-30 2003-03-25 Schering Corporation Crystallizable farnesyl protein transferase compositions, crystals thereby obtained, and methods for use
DE19835850A1 (de) 1998-08-07 2000-02-10 Basf Ag Verwendung von Hemmstoffen der HMG-CoA-Reduktase zur Senkung des Cholesteringehaltes in Geflügelei
US6156746A (en) 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
ES2237125T3 (es) 1998-08-27 2005-07-16 Pfizer Products Inc. Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
ID27562A (id) 1998-08-27 2001-04-12 Pfizer Prod Inc Turunan-turunan kinolin-2-ona tersubstitusi alkunil yang berguna sebagai zat anti kanker
US6535820B1 (en) 1998-08-28 2003-03-18 Schering Corporation Crystalline farnesyl protein transferase compositions and methods for use
US6329376B1 (en) 1998-10-29 2001-12-11 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP1006113A1 (en) 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US6191147B1 (en) 1998-12-24 2001-02-20 Ppd Discovery, Inc. Pyrazole compounds and uses thereof
PL349839A1 (en) 1999-02-11 2002-09-23 Pfizer Prod Inc Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
AU3386600A (en) 1999-03-03 2000-09-21 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6586447B1 (en) 1999-04-01 2003-07-01 Pfizer Inc 3,3-disubstituted-oxindole derivatives useful as anticancer agents
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
US6458935B1 (en) 1999-06-23 2002-10-01 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
AU6098300A (en) 1999-07-16 2001-02-05 Human Genome Sciences, Inc. Follistatin-3
WO2001018006A1 (en) 1999-09-09 2001-03-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
PT1106612E (pt) 1999-11-30 2004-06-30 Pfizer Prod Inc Derivados de quinolina uteis para inibir a farnesil-proteina-transferase
US6403581B1 (en) 2000-01-19 2002-06-11 American Cyanamid Company Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
KR100372911B1 (ko) 2000-03-22 2003-02-17 한국생명공학연구원 파네실 전이효소의 저해 활성, 세포 주기의 조절 활성 및신생혈관유도 저해 활성을 갖는 9-아세틸아테미놀라이드화합물, 이의 분리 방법 및 이를 포함하는 약학 조성물
EP1337522B1 (en) 2000-11-29 2007-08-29 Schering Corporation farnesyl protein transferase inhibitors
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
DE60310944T3 (de) 2002-08-05 2017-08-03 Silence Therapeutics Gmbh Weitere neue formen von interferierende rns moleküle
US6649638B1 (en) 2002-08-14 2003-11-18 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
JP4691041B2 (ja) * 2003-11-20 2011-06-01 チルドレンズ ホスピタル メディカル センター Gtpアーゼ阻害剤および使用方法
US8383124B2 (en) * 2008-03-12 2013-02-26 Children's Hospital Medical Center Mobilization of hematopoietic stem cells
WO2010010027A1 (en) * 2008-07-23 2010-01-28 Vib Vzw Antifungal compounds
JP6001650B2 (ja) * 2011-05-23 2016-10-05 昂科生物医学技術(蘇州)有限公司 Cdc42抑制剤およびその応用
US9980942B2 (en) * 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
WO2019140300A1 (en) * 2018-01-11 2019-07-18 Fred Hutchinson Cancer Research Center Compositions and methods to promote thymic regeneration
WO2021011800A1 (en) * 2019-07-17 2021-01-21 Children's Hospital Medical Center Method of treating neoplastic diseases with a cdc42-specific inhibitor

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