JP2022544031A - リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 - Google Patents

リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 Download PDF

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JP2022544031A
JP2022544031A JP2022505359A JP2022505359A JP2022544031A JP 2022544031 A JP2022544031 A JP 2022544031A JP 2022505359 A JP2022505359 A JP 2022505359A JP 2022505359 A JP2022505359 A JP 2022505359A JP 2022544031 A JP2022544031 A JP 2022544031A
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JP2022544031A5 (enExample
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ウルフギャング ハンプレヒト，ディーター
ドロシー フィンドレー，アリソン
イヴァン ターナー，クレイグ
デオダール，マンダル
エルサ グレコ，アンジェリーク
ジャロリメック，ウルフギャング
ヂョウ，ウェンビン
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ファーマクシス リミテッド
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    • C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022505359A 2019-07-25 2020-07-24 リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 Pending JP2022544031A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019902641A AU2019902641A0 (en) 2019-07-25 Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof
AU2019902641 2019-07-25
PCT/AU2020/050759 WO2021012014A1 (en) 2019-07-25 2020-07-24 Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof

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JP2022544031A true JP2022544031A (ja) 2022-10-17
JP2022544031A5 JP2022544031A5 (enExample) 2023-07-28

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US (1) US20220251036A1 (enExample)
EP (1) EP4003952A4 (enExample)
JP (1) JP2022544031A (enExample)
KR (1) KR20220040480A (enExample)
CN (1) CN114286816B (enExample)
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BR (1) BR112022000782A2 (enExample)
CA (1) CA3145738A1 (enExample)
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EP4173639A4 (en) 2020-06-26 2024-03-13 RaQualia Pharma Inc. METHOD FOR SELECTING A CANCER PATIENT FOR WHICH COMBINATION THERAPY OF A RETINOID AND A CANCER TREATMENT AGENT WILL BE EFFECTIVE, AND COMBINATION DRUG OF A RETINOID AND A CANCER TREATMENT AGENT
CN113440477B (zh) * 2021-08-12 2022-10-11 海南海神同洲制药有限公司 一种低粘度酮康唑乳膏及其制备方法
US12233056B2 (en) 2022-04-06 2025-02-25 Syntara Limited Lysyl oxidase inhibitors for treating myeloid malignancies
GB202209624D0 (en) 2022-06-30 2022-08-17 Institute Of Cancer Res Royal Cancer Hospital Prodrugs
GB202209622D0 (en) 2022-06-30 2022-08-17 Institute Of Cancer Res Royal Cancer Hospital Compounds

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JP2011504485A (ja) * 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
JP2018512381A (ja) * 2015-03-06 2018-05-17 ファーマケア，インク． フッ素化リシルオキシダーゼ様２阻害剤とその使用
WO2018157190A1 (en) * 2017-03-02 2018-09-07 Pharmaxis Ltd. Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof

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CA2871793C (en) * 2012-05-02 2020-09-15 Pharmaxis Ltd. Substituted 3-haloallylamine inhibitors of ssao and uses thereof
AU2017218889A1 (en) * 2016-02-09 2018-08-30 Pharmakea, Inc. Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
SG11201806700RA (en) * 2016-02-12 2018-09-27 Pharmaxis Ltd Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
GB201716871D0 (en) * 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds
AR115906A1 (es) * 2018-08-03 2021-03-10 Pharmaxis Ltd Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504485A (ja) * 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
JP2018512381A (ja) * 2015-03-06 2018-05-17 ファーマケア，インク． フッ素化リシルオキシダーゼ様２阻害剤とその使用
WO2018157190A1 (en) * 2017-03-02 2018-09-07 Pharmaxis Ltd. Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof

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CN114286816B (zh) 2024-08-20
AU2020317374A1 (en) 2022-02-03
ZA202202376B (en) 2023-11-29
EP4003952A1 (en) 2022-06-01
EP4003952A4 (en) 2023-08-23
CA3145738A1 (en) 2021-01-28
WO2021012014A1 (en) 2021-01-28
BR112022000782A2 (pt) 2022-03-15
CN114286816A (zh) 2022-04-05

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