JP2022543421A - 毒性が低減されたハイブリッドアムホテリシンｂ誘導体 - Google Patents

毒性が低減されたハイブリッドアムホテリシンｂ誘導体 Download PDF

Info

Publication number
JP2022543421A
JP2022543421A JP2022506949A JP2022506949A JP2022543421A JP 2022543421 A JP2022543421 A JP 2022543421A JP 2022506949 A JP2022506949 A JP 2022506949A JP 2022506949 A JP2022506949 A JP 2022506949A JP 2022543421 A JP2022543421 A JP 2022543421A
Authority
JP
Japan
Prior art keywords
unsubstituted
substituted
alkyl
compound
carbocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022506949A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022543421A5 (https=
Inventor
ディー バーク，マーティン
マジ，アルン
ヂャン，ジアバーオー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of JP2022543421A publication Critical patent/JP2022543421A/ja
Publication of JP2022543421A5 publication Critical patent/JP2022543421A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022506949A 2019-08-08 2020-08-07 毒性が低減されたハイブリッドアムホテリシンｂ誘導体 Pending JP2022543421A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884471P 2019-08-08 2019-08-08
US62/884,471 2019-08-08
US201962927731P 2019-10-30 2019-10-30
US62/927,731 2019-10-30
PCT/US2020/045399 WO2021026450A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Publications (2)

Publication Number Publication Date
JP2022543421A true JP2022543421A (ja) 2022-10-12
JP2022543421A5 JP2022543421A5 (https=) 2023-08-08

Family

ID=74503744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022506949A Pending JP2022543421A (ja) 2019-08-08 2020-08-07 毒性が低減されたハイブリッドアムホテリシンｂ誘導体

Country Status (9)

Country Link
US (1) US20230000891A1 (https=)
EP (1) EP4009984A4 (https=)
JP (1) JP2022543421A (https=)
KR (1) KR20220058547A (https=)
CN (1) CN114502173A (https=)
AU (1) AU2020325054A1 (https=)
CA (1) CA3149819A1 (https=)
IL (1) IL290290A (https=)
WO (1) WO2021026450A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
JP2021536462A (ja) * 2018-09-07 2021-12-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイThe Board Of Trustees Of The University Of Illinois 毒性が低減されたハイブリッドアムホテリシンｂ誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
KR102548341B1 (ko) * 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
WO2016061437A1 (en) * 2014-10-17 2016-04-21 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
WO2016112260A1 (en) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175875A1 (en) * 2014-05-16 2015-11-19 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
JP2021536462A (ja) * 2018-09-07 2021-12-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイThe Board Of Trustees Of The University Of Illinois 毒性が低減されたハイブリッドアムホテリシンｂ誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ORG. LETT., vol. 13, JPN6024035927, 2011, pages 1390 - 1393, ISSN: 0005415091 *

Also Published As

Publication number Publication date
CN114502173A (zh) 2022-05-13
CA3149819A1 (en) 2021-02-11
EP4009984A4 (en) 2023-09-06
KR20220058547A (ko) 2022-05-09
WO2021026450A1 (en) 2021-02-11
IL290290A (en) 2022-04-01
US20230000891A1 (en) 2023-01-05
AU2020325054A1 (en) 2022-03-03
EP4009984A1 (en) 2022-06-15

Similar Documents

Publication Publication Date Title
JP7636004B2 (ja) アムホテリシンｂのハイブリッドアミド誘導体
EP3674298B9 (de) Substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
CA2925904C (en) Amphotericin b derivatives with improved therapeutic index
JP7477177B2 (ja) 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
JP6726192B2 (ja) アムホテリシンｂの尿素誘導体の簡便な合成法
CN1432008A (zh) 喹诺酮羧酸衍生物
JP2022543421A (ja) 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
JP2025521589A (ja) Ｄｓｇｐｅｇ２ｋミセル中のアムホテリシンｂハイブリッドアミド誘導体の製剤
JP7656359B2 (ja) アムホテリシンｂのハイブリッドアミド誘導体
WO2021030183A1 (en) Combination treatment of systemic fungal infections

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230731

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230731

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240912

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20241126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250212

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250415