IL290290A - History of amphotericin b hybrids with reduced toxicity - Google Patents
History of amphotericin b hybrids with reduced toxicityInfo
- Publication number
- IL290290A IL290290A IL290290A IL29029022A IL290290A IL 290290 A IL290290 A IL 290290A IL 290290 A IL290290 A IL 290290A IL 29029022 A IL29029022 A IL 29029022A IL 290290 A IL290290 A IL 290290A
- Authority
- IL
- Israel
- Prior art keywords
- amphotericin
- hybrid
- derivatives
- reduced toxicity
- toxicity
- Prior art date
Links
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical class O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962884471P | 2019-08-08 | 2019-08-08 | |
| US201962927731P | 2019-10-30 | 2019-10-30 | |
| PCT/US2020/045399 WO2021026450A1 (en) | 2019-08-08 | 2020-08-07 | Hybrid amphotericin b derivatives with reduced toxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL290290A true IL290290A (en) | 2022-04-01 |
Family
ID=74503744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL290290A IL290290A (en) | 2019-08-08 | 2022-02-01 | History of amphotericin b hybrids with reduced toxicity |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230000891A1 (https=) |
| EP (1) | EP4009984A4 (https=) |
| JP (1) | JP2022543421A (https=) |
| KR (1) | KR20220058547A (https=) |
| CN (1) | CN114502173A (https=) |
| AU (1) | AU2020325054A1 (https=) |
| CA (1) | CA3149819A1 (https=) |
| IL (1) | IL290290A (https=) |
| WO (1) | WO2021026450A1 (https=) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0431874A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Novel compounds |
| US5981721A (en) * | 1997-10-23 | 1999-11-09 | Karykion Corporation | Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof |
| KR102548341B1 (ko) * | 2013-10-07 | 2023-06-26 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 개선된 치료 지수를 갖는 암포테리신 b 유도체 |
| ES2749927T3 (es) * | 2014-05-16 | 2020-03-24 | Univ Illinois | Derivado de anfotericina b con toxicidad reducida |
| WO2016014779A1 (en) * | 2014-07-23 | 2016-01-28 | The Board Of Trustees Of The University Of Illinois | Antifungal polyene macrolide derivatives with reduced mammalian toxicity |
| WO2016061437A1 (en) * | 2014-10-17 | 2016-04-21 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin b |
| WO2016112260A1 (en) * | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin b |
| JP7240811B2 (ja) * | 2015-04-15 | 2023-03-16 | スファンガ セラピューティクス インコーポレイテッド | アムホテリシンｂの誘導体 |
| CA3111565A1 (en) * | 2018-09-07 | 2020-03-12 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
-
2020
- 2020-08-07 KR KR1020227007290A patent/KR20220058547A/ko not_active Ceased
- 2020-08-07 EP EP20851052.9A patent/EP4009984A4/en active Pending
- 2020-08-07 AU AU2020325054A patent/AU2020325054A1/en not_active Abandoned
- 2020-08-07 CA CA3149819A patent/CA3149819A1/en active Pending
- 2020-08-07 CN CN202080070409.4A patent/CN114502173A/zh active Pending
- 2020-08-07 JP JP2022506949A patent/JP2022543421A/ja active Pending
- 2020-08-07 US US17/633,282 patent/US20230000891A1/en not_active Abandoned
- 2020-08-07 WO PCT/US2020/045399 patent/WO2021026450A1/en not_active Ceased
-
2022
- 2022-02-01 IL IL290290A patent/IL290290A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114502173A (zh) | 2022-05-13 |
| CA3149819A1 (en) | 2021-02-11 |
| EP4009984A4 (en) | 2023-09-06 |
| KR20220058547A (ko) | 2022-05-09 |
| WO2021026450A1 (en) | 2021-02-11 |
| US20230000891A1 (en) | 2023-01-05 |
| AU2020325054A1 (en) | 2022-03-03 |
| JP2022543421A (ja) | 2022-10-12 |
| EP4009984A1 (en) | 2022-06-15 |
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