CN114502173A - 具有降低的毒性的混合两性霉素b衍生物 - Google Patents

具有降低的毒性的混合两性霉素b衍生物 Download PDF

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Publication number
CN114502173A
CN114502173A CN202080070409.4A CN202080070409A CN114502173A CN 114502173 A CN114502173 A CN 114502173A CN 202080070409 A CN202080070409 A CN 202080070409A CN 114502173 A CN114502173 A CN 114502173A
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unsubstituted
substituted
alkyl
compound
group
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CN202080070409.4A
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English (en)
Chinese (zh)
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M·D·伯克
A·马吉
J·张
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University of Illinois System
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University of Illinois System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202080070409.4A 2019-08-08 2020-08-07 具有降低的毒性的混合两性霉素b衍生物 Pending CN114502173A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884471P 2019-08-08 2019-08-08
US62/884471 2019-08-08
US201962927731P 2019-10-30 2019-10-30
US62/927731 2019-10-30
PCT/US2020/045399 WO2021026450A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
CN114502173A true CN114502173A (zh) 2022-05-13

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ID=74503744

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080070409.4A Pending CN114502173A (zh) 2019-08-08 2020-08-07 具有降低的毒性的混合两性霉素b衍生物

Country Status (9)

Country Link
US (1) US20230000891A1 (https=)
EP (1) EP4009984A4 (https=)
JP (1) JP2022543421A (https=)
KR (1) KR20220058547A (https=)
CN (1) CN114502173A (https=)
AU (1) AU2020325054A1 (https=)
CA (1) CA3149819A1 (https=)
IL (1) IL290290A (https=)
WO (1) WO2021026450A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
US20170088572A1 (en) * 2014-05-16 2017-03-30 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
WO2016061437A1 (en) * 2014-10-17 2016-04-21 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
WO2016112260A1 (en) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
CA3111565A1 (en) * 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721A (zh) * 2013-10-07 2016-08-10 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
US20170088572A1 (en) * 2014-05-16 2017-03-30 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MITCHELL P. CROATT，等: "Probing the Role of the Mycosamine C2′-OH on the Activity of Amphotericin B", 《ORG. LETT.》, vol. 13, no. 6, pages 1391 *

Also Published As

Publication number Publication date
CA3149819A1 (en) 2021-02-11
EP4009984A4 (en) 2023-09-06
KR20220058547A (ko) 2022-05-09
WO2021026450A1 (en) 2021-02-11
IL290290A (en) 2022-04-01
US20230000891A1 (en) 2023-01-05
AU2020325054A1 (en) 2022-03-03
JP2022543421A (ja) 2022-10-12
EP4009984A1 (en) 2022-06-15

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