KR20220058547A - 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체 - Google Patents

감소된 독성을 갖는 하이브리드 암포테리신 b 유도체 Download PDF

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Publication number
KR20220058547A
KR20220058547A KR1020227007290A KR20227007290A KR20220058547A KR 20220058547 A KR20220058547 A KR 20220058547A KR 1020227007290 A KR1020227007290 A KR 1020227007290A KR 20227007290 A KR20227007290 A KR 20227007290A KR 20220058547 A KR20220058547 A KR 20220058547A
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South Korea
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Korean (ko)
Inventor
마틴 디. 버크
아룬 마지
지아바오 장
Original Assignee
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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Publication of KR20220058547A publication Critical patent/KR20220058547A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020227007290A 2019-08-08 2020-08-07 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체 Ceased KR20220058547A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884471P 2019-08-08 2019-08-08
US62/884,471 2019-08-08
US201962927731P 2019-10-30 2019-10-30
US62/927,731 2019-10-30
PCT/US2020/045399 WO2021026450A1 (en) 2019-08-08 2020-08-07 Hybrid amphotericin b derivatives with reduced toxicity

Publications (1)

Publication Number Publication Date
KR20220058547A true KR20220058547A (ko) 2022-05-09

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ID=74503744

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227007290A Ceased KR20220058547A (ko) 2019-08-08 2020-08-07 감소된 독성을 갖는 하이브리드 암포테리신 b 유도체

Country Status (9)

Country Link
US (1) US20230000891A1 (https=)
EP (1) EP4009984A4 (https=)
JP (1) JP2022543421A (https=)
KR (1) KR20220058547A (https=)
CN (1) CN114502173A (https=)
AU (1) AU2020325054A1 (https=)
CA (1) CA3149819A1 (https=)
IL (1) IL290290A (https=)
WO (1) WO2021026450A1 (https=)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
KR102548341B1 (ko) * 2013-10-07 2023-06-26 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 개선된 치료 지수를 갖는 암포테리신 b 유도체
ES2749927T3 (es) * 2014-05-16 2020-03-24 Univ Illinois Derivado de anfotericina b con toxicidad reducida
WO2016014779A1 (en) * 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
WO2016061437A1 (en) * 2014-10-17 2016-04-21 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin b
WO2016112260A1 (en) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
CA3111565A1 (en) * 2018-09-07 2020-03-12 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity

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Publication number Publication date
CN114502173A (zh) 2022-05-13
CA3149819A1 (en) 2021-02-11
EP4009984A4 (en) 2023-09-06
WO2021026450A1 (en) 2021-02-11
IL290290A (en) 2022-04-01
US20230000891A1 (en) 2023-01-05
AU2020325054A1 (en) 2022-03-03
JP2022543421A (ja) 2022-10-12
EP4009984A1 (en) 2022-06-15

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