|
US3854480A
(en)
|
1969-04-01 |
1974-12-17 |
Alza Corp |
Drug-delivery system
|
|
US3832253A
(en)
|
1973-03-21 |
1974-08-27 |
Baxter Laboratories Inc |
Method of making an inflatable balloon catheter
|
|
US4667014A
(en)
|
1983-03-07 |
1987-05-19 |
Syntex (U.S.A.) Inc. |
Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
|
|
US4452775A
(en)
|
1982-12-03 |
1984-06-05 |
Syntex (U.S.A.) Inc. |
Cholesterol matrix delivery system for sustained release of macromolecules
|
|
CA1200416A
(en)
|
1983-05-13 |
1986-02-11 |
Societe Des Produits Nestle S.A. |
Food process
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
JPH04167172A
(ja)
|
1990-10-31 |
1992-06-15 |
Nec Corp |
ベクトルプロセッサ
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
CA2261019A1
(en)
|
1996-07-15 |
1998-01-22 |
Mayo Foundation For Medical Education And Research |
Methods to detect hk2 polypeptides
|
|
US6818749B1
(en)
|
1998-10-31 |
2004-11-16 |
The United States Of America As Represented By The Department Of Health And Human Services |
Variants of humanized anti carcinoma monoclonal antibody cc49
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
IL155977A0
(en)
|
2000-11-30 |
2003-12-23 |
Medarex Inc |
Transgenic transchromosomal rodents for making human antibodies
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
US20070218047A1
(en)
*
|
2004-01-28 |
2007-09-20 |
Bayer Healthcare Ag |
Diagnostics and Therapeutics for Diseases Associated with Kallikrein 2 (KLK2)
|
|
CN101198698B
(zh)
|
2005-03-31 |
2014-03-19 |
中外制药株式会社 |
通过调节多肽缔合制备多肽的方法
|
|
DE102005028778A1
(de)
|
2005-06-22 |
2006-12-28 |
SUNJÜT Deutschland GmbH |
Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
|
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
US8748356B2
(en)
|
2007-10-19 |
2014-06-10 |
Janssen Biotech, Inc. |
Methods for use in human-adapting monoclonal antibodies
|
|
JP2011507519A
(ja)
|
2007-12-19 |
2011-03-10 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
pIX又はpVIIへの融合を介したヒトデノボpIXファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
|
|
JP5646457B2
(ja)
|
2008-04-29 |
2014-12-24 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリン及びその使用
|
|
JP2012505654A
(ja)
|
2008-10-14 |
2012-03-08 |
ヤンセン バイオテツク,インコーポレーテツド |
抗体をヒト化及び親和性成熟する方法
|
|
US8637454B2
(en)
|
2009-01-06 |
2014-01-28 |
Dyax Corp. |
Treatment of mucositis with kallikrein inhibitors
|
|
AU2010245011B2
(en)
|
2009-04-27 |
2015-09-03 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
PL3251503T3
(pl)
|
2010-03-31 |
2024-07-08 |
Ablexis, Llc |
Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych
|
|
JP6040148B2
(ja)
|
2010-04-20 |
2016-12-07 |
ゲンマブ エー/エス |
ヘテロ二量体抗体Fc含有タンパク質およびその産生方法
|
|
EP2569337A1
(en)
|
2010-05-14 |
2013-03-20 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
EP2420253A1
(en)
|
2010-08-20 |
2012-02-22 |
Leadartis, S.L. |
Engineering multifunctional and multivalent molecules with collagen XV trimerization domain
|
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
DK2771364T3
(da)
|
2011-10-27 |
2019-08-19 |
Genmab As |
Fremstilling af heterodimere proteiner
|
|
US9345782B2
(en)
|
2011-10-28 |
2016-05-24 |
Fredax Ab |
Therapeutic agents and uses thereof
|
|
PL2773671T3
(pl)
|
2011-11-04 |
2022-01-24 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerycznego z mutacjami w domenie fc
|
|
PT2794905T
(pt)
|
2011-12-20 |
2020-06-30 |
Medimmune Llc |
Polipéptidos modificados para estrutura de anticorpos bispecíficos
|
|
DK2838918T3
(da)
|
2012-04-20 |
2019-08-12 |
Merus Nv |
Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler
|
|
US20140154253A1
(en)
|
2012-07-13 |
2014-06-05 |
Zymeworks Inc. |
Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs
|
|
SG11201504676VA
(en)
|
2012-12-14 |
2015-07-30 |
Omt Inc |
Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
|
|
AU2014237635B2
(en)
|
2013-03-15 |
2020-03-12 |
Janssen Biologics B.V. |
Manufacturing methods to control C-terminal lysine, galactose and sialic acid content in recombinant proteins
|
|
FI3553088T3
(fi)
*
|
2013-11-19 |
2026-04-21 |
Janssen Biotech Inc |
Humanisoitu kallikreiini-2-antivasta-aine
|
|
GB2520353A
(en)
*
|
2013-11-19 |
2015-05-20 |
Fredax Ab |
Antibody polypeptides and uses thereof
|
|
US11390687B2
(en)
|
2015-01-02 |
2022-07-19 |
Takeda Pharmaceutical Company Limited |
Bispecific antibodies against plasma kallikrein and Factor XII
|
|
CN107530376A
(zh)
|
2015-02-18 |
2018-01-02 |
恩立夫克治疗有限责任公司 |
用于癌症治疗的联合免疫疗法和细胞因子控制疗法
|
|
HK1254967A1
(zh)
|
2015-10-02 |
2019-08-02 |
豪夫迈‧罗氏有限公司 |
结合间皮素和cd3的双特异性t细胞活化性抗原结合分子
|
|
WO2017087826A1
(en)
|
2015-11-18 |
2017-05-26 |
Memorial Sloan Kettering Cancer Center |
Systems, methods, and compositions for imaging androgen receptor axis activity in carcinoma, and related therapeutic compositions and methods
|
|
US10882918B2
(en)
|
2016-09-30 |
2021-01-05 |
Hoffmann-La Roche Inc. |
Bispecific T cell activating antigen binding molecules
|
|
AU2018258045B2
(en)
|
2017-04-26 |
2024-02-29 |
Eureka Therapeutics, Inc. |
Chimeric antibody/T-cell receptor constructs and uses thereof
|
|
ES2980055T3
(es)
|
2017-09-22 |
2024-09-27 |
Kite Pharma Inc |
Polipéptidos quiméricos y usos de los mismos
|
|
CN112912397B
(zh)
|
2018-05-24 |
2025-03-14 |
詹森生物科技公司 |
抗cd3抗体及其用途
|
|
TWI894157B
(zh)
*
|
2019-07-26 |
2025-08-21 |
美商健生生物科技公司 |
包含血管舒緩素相關肽酶2抗原結合域之蛋白質及其用途
|
|
UY38800A
(es)
|
2019-07-26 |
2021-01-29 |
Janssen Biotech Inc |
Receptor de antígeno quimérico (car) anti-hk2
|
|
JP2024503924A
(ja)
|
2021-01-27 |
2024-01-29 |
ヤンセン バイオテツク,インコーポレーテツド |
カリクレイン関連ペプチダーゼ2抗原結合ドメインを含む免疫コンジュゲート及びその使用
|