JP2022531388A5 - - Google Patents
Info
- Publication number
- JP2022531388A5 JP2022531388A5 JP2021564995A JP2021564995A JP2022531388A5 JP 2022531388 A5 JP2022531388 A5 JP 2022531388A5 JP 2021564995 A JP2021564995 A JP 2021564995A JP 2021564995 A JP2021564995 A JP 2021564995A JP 2022531388 A5 JP2022531388 A5 JP 2022531388A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- phenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025062493A JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962842849P | 2019-05-03 | 2019-05-03 | |
| US62/842,849 | 2019-05-03 | ||
| US202062982864P | 2020-02-28 | 2020-02-28 | |
| US62/982,864 | 2020-02-28 | ||
| PCT/US2020/031046 WO2020227101A1 (en) | 2019-05-03 | 2020-05-01 | Kcnt1 inhibitors and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025062493A Division JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022531388A JP2022531388A (ja) | 2022-07-06 |
| JP2022531388A5 true JP2022531388A5 (cg-RX-API-DMAC10.html) | 2023-05-11 |
| JP7667573B2 JP7667573B2 (ja) | 2025-04-23 |
Family
ID=73051241
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564995A Active JP7667573B2 (ja) | 2019-05-03 | 2020-05-01 | Ｋｃｎｔ１阻害剤および使用する方法 |
| JP2025062493A Pending JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025062493A Pending JP2025102975A (ja) | 2019-05-03 | 2025-04-04 | Ｋｃｎｔ１阻害剤および使用する方法 |
Country Status (17)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12590083B2 (en) | 2019-01-25 | 2026-03-31 | University Of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (SPNS2) for use in therapy |
| EP4446314A3 (en) * | 2019-05-03 | 2025-03-12 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| EP4110317B1 (en) * | 2020-02-28 | 2025-11-19 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| WO2022056042A1 (en) * | 2020-09-09 | 2022-03-17 | University Of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (spns2) for use in therapy |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| TW202227424A (zh) * | 2020-11-27 | 2022-07-16 | 大陸商瑞石生物醫藥有限公司 | 芳基或雜芳基取代５員芳雜環化合物及其用途 |
| US20240043415A1 (en) * | 2020-12-22 | 2024-02-08 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| EP4329735B1 (en) * | 2021-04-29 | 2026-02-25 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| WO2022231872A1 (en) * | 2021-04-29 | 2022-11-03 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| WO2023211850A1 (en) * | 2022-04-25 | 2023-11-02 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising an isoxazole or oxadiazole core and methods of use |
| EP4536644A4 (en) * | 2022-06-08 | 2026-05-20 | Praxis Prec Medicines Inc | KCNT1 INHIBITORS COMPRISING AN ISOXAZOLE OR OXADIAZOLE NUCLEUS AND METHODS OF USE |
| CN116813505B (zh) * | 2023-06-29 | 2025-09-02 | 爱斯特（成都）生物制药股份有限公司 | 一种制备o-甲基-n-苄氧羰基-l-高丝氨酸的方法 |
| CN122555695A (zh) * | 2023-11-29 | 2026-08-11 | 爱克堤欧生物科学股份有限公司 | 可用作kcnt1抑制剂的杂环化合物 |
| WO2026082925A1 (en) | 2024-10-18 | 2026-04-23 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of their use |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| TW200301698A (en) * | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
| JP2005060255A (ja) * | 2003-08-20 | 2005-03-10 | Nippon Nohyaku Co Ltd | カルボキサミド類及びこれを有効成分とする有害生物防除剤 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| BRPI0713187A2 (pt) * | 2006-07-20 | 2012-10-16 | Mehmet Kahraman | método de inibir rho-quinase, método de tratamento de doença mediada por rho-quinase, composto e composição farmacêutica |
| CA2903979A1 (en) * | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CA2962922C (en) | 2014-09-29 | 2021-10-26 | The Scripps Research Institute | Sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders |
| EP3275440B1 (en) * | 2015-03-25 | 2022-05-04 | National Center for Geriatrics and Gerontology | Novel oxadiazole derivative and pharmaceutical containing same |
| JPWO2017170826A1 (ja) * | 2016-03-30 | 2019-02-14 | 味の素株式会社 | グルカゴン様ペプチド−１受容体作用増強活性を有する化合物 |
| WO2018187480A1 (en) * | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| EP4110317B1 (en) * | 2020-02-28 | 2025-11-19 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| KR20230005168A (ko) * | 2020-03-23 | 2023-01-09 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| CN116075297A (zh) * | 2020-07-06 | 2023-05-05 | 普拉西斯精密医药公司 | Kcnt1抑制剂和使用方法 |
| US11773088B2 (en) * | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| US20240043415A1 (en) * | 2020-12-22 | 2024-02-08 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| EP4329735B1 (en) * | 2021-04-29 | 2026-02-25 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
-
2020
- 2020-05-01 CN CN202510784123.7A patent/CN120817941A/zh active Pending
- 2020-05-01 WO PCT/US2020/031046 patent/WO2020227101A1/en not_active Ceased
- 2020-05-01 SG SG11202112158YA patent/SG11202112158YA/en unknown
- 2020-05-01 AU AU2020267356A patent/AU2020267356B2/en active Active
- 2020-05-01 KR KR1020217039174A patent/KR20220016086A/ko not_active Ceased
- 2020-05-01 CN CN202080047961.1A patent/CN114269340A/zh active Pending
- 2020-05-01 EP EP20801870.5A patent/EP3962481A4/en active Pending
- 2020-05-01 MX MX2021013421A patent/MX2021013421A/es unknown
- 2020-05-01 US US17/607,802 patent/US20220259193A1/en active Pending
- 2020-05-01 PE PE2021001828A patent/PE20220016A1/es unknown
- 2020-05-01 CA CA3139063A patent/CA3139063A1/en active Pending
- 2020-05-01 JP JP2021564995A patent/JP7667573B2/ja active Active
- 2020-05-01 BR BR112021022067A patent/BR112021022067A2/pt unknown
-
2021
- 2021-11-01 IL IL287768A patent/IL287768A/en unknown
- 2021-11-02 CL CL2021002877A patent/CL2021002877A1/es unknown
- 2021-11-03 SA SA521430751A patent/SA521430751B1/ar unknown
- 2021-12-02 CO CONC2021/0016471A patent/CO2021016471A2/es unknown
- 2021-12-03 EC ECSENADI202187884A patent/ECSP21087884A/es unknown
-
2024
- 2024-07-08 CL CL2024002067A patent/CL2024002067A1/es unknown
-
2025
- 2025-04-04 JP JP2025062493A patent/JP2025102975A/ja active Pending