JP2022530028A5 - - Google Patents
Info
- Publication number
- JP2022530028A5 JP2022530028A5 JP2021562948A JP2021562948A JP2022530028A5 JP 2022530028 A5 JP2022530028 A5 JP 2022530028A5 JP 2021562948 A JP2021562948 A JP 2021562948A JP 2021562948 A JP2021562948 A JP 2021562948A JP 2022530028 A5 JP2022530028 A5 JP 2022530028A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- fumarate
- compound
- temperature
- fumaric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962837858P | 2019-04-24 | 2019-04-24 | |
| US62/837,858 | 2019-04-24 | ||
| PCT/CA2020/050535 WO2020215155A1 (en) | 2019-04-24 | 2020-04-23 | Crystal form s4 of the plk4 inhibitor (lr,2s)-(e)-2-(3-(4-((cis-2,6-dimethylmorpholino)methyl)styryl)- 1 h-imidazol-6- yl)-5'-methoxyspiro[cyclopropane-l,3'-indolin]-2'-one fumarate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022530028A JP2022530028A (ja) | 2022-06-27 |
| JP2022530028A5 true JP2022530028A5 (enExample) | 2023-04-25 |
| JP7705351B2 JP7705351B2 (ja) | 2025-07-09 |
Family
ID=72940551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021562948A Active JP7705351B2 (ja) | 2019-04-24 | 2020-04-23 | ＰＬＫ４阻害剤である（１Ｒ，２Ｓ）－（Ｅ）－２－（３－（４－（（ｃｉｓ－２，６－ジメチルモルホリノ）メチル）スチリル）－１Ｈ－イミダゾール－６－イル）－５’－メトキシスピロ［シクロプロパン－１，３’－インドリン］－２’－オンフマル酸塩のＳ４結晶形 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US12325700B2 (enExample) |
| EP (1) | EP3959209A4 (enExample) |
| JP (1) | JP7705351B2 (enExample) |
| KR (1) | KR20220004102A (enExample) |
| CN (1) | CN113966330B (enExample) |
| AU (1) | AU2020264143B2 (enExample) |
| BR (1) | BR112021021106A2 (enExample) |
| CA (1) | CA3137191A1 (enExample) |
| EA (1) | EA202192903A1 (enExample) |
| IL (1) | IL287394A (enExample) |
| MA (1) | MA55767A (enExample) |
| MX (1) | MX2021012993A (enExample) |
| SA (1) | SA521430647B1 (enExample) |
| SG (1) | SG11202111003UA (enExample) |
| TW (1) | TWI862582B (enExample) |
| WO (1) | WO2020215155A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220124177A (ko) | 2019-12-06 | 2022-09-13 | 유니버시티 헬스 네트워크 | 급성 골수성 백혈병 또는 골수형성이상증후군의 치료방법 |
| TWI926033B (zh) | 2021-05-11 | 2026-05-21 | 美商歐瑞克製藥公司 | 類ｐｏｌｏ激酶４抑制劑 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7205328B2 (en) | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| DE102005005395A1 (de) | 2005-02-03 | 2006-08-10 | Schering Aktiengesellschaft | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| GB0606234D0 (en) | 2006-03-29 | 2006-05-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutically acceptable salts and polymorphic forms |
| BRPI0817315A2 (pt) | 2007-09-25 | 2015-03-17 | Takeda Pharmaceutical | Inibidores de quinase do tipo polo |
| EP2235004A4 (en) | 2007-12-21 | 2011-05-04 | Univ Health Network | INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT |
| WO2010115279A1 (en) | 2009-04-06 | 2010-10-14 | University Health Network | Kinase inhibitors and method of treating cancer with same |
| WO2010125004A1 (en) | 2009-04-29 | 2010-11-04 | Nerviano Medical Sciences S.R.L. | Cdk inhibitor salts |
| TWI516262B (zh) | 2010-04-06 | 2016-01-11 | 健康網路大學 | 激酶抑制劑及以其治療癌症的方法 |
| CA2803446C (en) | 2010-07-02 | 2019-06-04 | University Health Network | Use of plk4 antagonists for treating pten mutant diseases |
| WO2012048411A1 (en) | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
| JP5808818B2 (ja) | 2010-11-25 | 2015-11-10 | ラツィオファーム・ゲーエムベーハー | アファチニブの新規塩及び多形形態 |
| EP2766352B1 (en) | 2011-10-12 | 2018-06-06 | University Health Network (UHN) | Indazole compounds as kinase inhibitors and method of treating cancer with same |
| TR201902875T4 (tr) * | 2013-10-18 | 2019-03-21 | Univ Health Network | Plk-4 inhibitörünün tuz ve kristal formları. |
| EA030089B1 (ru) | 2013-10-18 | 2018-06-29 | Юниверсити Хелс Нетуорк | Лечение рака поджелудочной железы |
-
2020
- 2020-04-23 EP EP20795605.3A patent/EP3959209A4/en active Pending
- 2020-04-23 MX MX2021012993A patent/MX2021012993A/es unknown
- 2020-04-23 CA CA3137191A patent/CA3137191A1/en active Pending
- 2020-04-23 KR KR1020217037777A patent/KR20220004102A/ko not_active Ceased
- 2020-04-23 US US17/605,108 patent/US12325700B2/en active Active
- 2020-04-23 TW TW109113591A patent/TWI862582B/zh active
- 2020-04-23 BR BR112021021106A patent/BR112021021106A2/pt unknown
- 2020-04-23 JP JP2021562948A patent/JP7705351B2/ja active Active
- 2020-04-23 WO PCT/CA2020/050535 patent/WO2020215155A1/en not_active Ceased
- 2020-04-23 SG SG11202111003UA patent/SG11202111003UA/en unknown
- 2020-04-23 AU AU2020264143A patent/AU2020264143B2/en active Active
- 2020-04-23 CN CN202080030678.8A patent/CN113966330B/zh active Active
- 2020-04-23 EA EA202192903A patent/EA202192903A1/ru unknown
- 2020-04-23 MA MA055767A patent/MA55767A/fr unknown
-
2021
- 2021-10-19 IL IL287394A patent/IL287394A/en unknown
- 2021-10-20 SA SA521430647A patent/SA521430647B1/ar unknown
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