JP2022522996A5 - - Google Patents
Info
- Publication number
- JP2022522996A5 JP2022522996A5 JP2021541524A JP2021541524A JP2022522996A5 JP 2022522996 A5 JP2022522996 A5 JP 2022522996A5 JP 2021541524 A JP2021541524 A JP 2021541524A JP 2021541524 A JP2021541524 A JP 2021541524A JP 2022522996 A5 JP2022522996 A5 JP 2022522996A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- pharmaceutical composition
- composition according
- polynucleotide
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024204975A JP2025032155A (ja) | 2019-01-18 | 2024-11-25 | オトフェリン遺伝子を回復させるａａｖ媒介遺伝子治療 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19305071.3 | 2019-01-18 | ||
| EP19305071 | 2019-01-18 | ||
| PCT/EP2020/051283 WO2020148458A1 (en) | 2019-01-18 | 2020-01-20 | Aav-mediated gene therapy restoring the otoferlin gene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024204975A Division JP2025032155A (ja) | 2019-01-18 | 2024-11-25 | オトフェリン遺伝子を回復させるａａｖ媒介遺伝子治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022522996A JP2022522996A (ja) | 2022-04-21 |
| JP2022522996A5 true JP2022522996A5 (https=) | 2024-05-10 |
| JP7595013B2 JP7595013B2 (ja) | 2024-12-05 |
Family
ID=65351986
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021541524A Active JP7595013B2 (ja) | 2019-01-18 | 2020-01-20 | オトフェリン遺伝子を回復させるａａｖ媒介遺伝子治療 |
| JP2024204975A Pending JP2025032155A (ja) | 2019-01-18 | 2024-11-25 | オトフェリン遺伝子を回復させるａａｖ媒介遺伝子治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024204975A Pending JP2025032155A (ja) | 2019-01-18 | 2024-11-25 | オトフェリン遺伝子を回復させるａａｖ媒介遺伝子治療 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20220125875A1 (https=) |
| EP (2) | EP4295913A3 (https=) |
| JP (2) | JP7595013B2 (https=) |
| KR (2) | KR20260046255A (https=) |
| CN (1) | CN113924109A (https=) |
| AU (2) | AU2020208933B2 (https=) |
| BR (1) | BR112021013996A2 (https=) |
| CA (1) | CA3126884A1 (https=) |
| DK (1) | DK3911354T5 (https=) |
| ES (1) | ES2960880T3 (https=) |
| FI (1) | FI3911354T3 (https=) |
| HR (1) | HRP20231296T1 (https=) |
| HU (1) | HUE063458T2 (https=) |
| IL (1) | IL284742B2 (https=) |
| LT (1) | LT3911354T (https=) |
| MX (1) | MX2021008622A (https=) |
| PL (1) | PL3911354T3 (https=) |
| PT (1) | PT3911354T (https=) |
| RS (1) | RS64794B1 (https=) |
| SI (1) | SI3911354T1 (https=) |
| SM (1) | SMT202300359T1 (https=) |
| WO (1) | WO2020148458A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102606810B1 (ko) | 2017-05-05 | 2023-11-27 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN112703016B (zh) | 2018-04-27 | 2024-11-22 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| CA3129422A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
| KR20220157944A (ko) | 2020-02-21 | 2022-11-29 | 아카우오스, 인크. | 인간 대상체에서 비-연령-연관 청각 장애를 치료하기 위한 조성물 및 방법 |
| CN115666658A (zh) | 2020-04-01 | 2023-01-31 | 佛罗里达州大学研究基金会 | 具有提高的治疗ush1b的安全性的双aav-myo7a载体 |
| AU2021376225A1 (en) * | 2020-11-06 | 2023-06-22 | Eli Lilly And Company | Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss |
| EP4294460A4 (en) * | 2021-02-19 | 2025-06-25 | Decibel Therapeutics, Inc. | Methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2023036966A1 (en) * | 2021-09-10 | 2023-03-16 | Institut Pasteur | Dual recombinant aav8 vector system encoding isoform 5 of otoferlin and uses thereof |
| JP2025530726A (ja) * | 2022-05-17 | 2025-09-17 | 復旦大学附属眼耳鼻喉科医院 | 聴力障害を治療するためのデュアルベクターシステム及びその使用 |
| CN117106824B (zh) * | 2022-05-17 | 2025-09-02 | 上海佑音医药生物科技有限公司 | 一种治疗听力损伤的双载体系统及其应用 |
| CN116925239B (zh) * | 2023-07-17 | 2024-10-18 | 苏州星奥拓维生物技术有限公司 | 双载体系统表达Otof基因的组合物和方法 |
| CN117305367A (zh) * | 2023-08-21 | 2023-12-29 | 复旦大学附属眼耳鼻喉科医院 | 一种表达全长耳畸蛋白的双aav载体系统及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| WO2003059396A1 (en) | 2002-01-11 | 2003-07-24 | Sergei Zolotukhin | Adiponectin gene therapy |
| WO2006036465A2 (en) | 2004-09-03 | 2006-04-06 | University Of Florida | Compositions and methods for treating cystic fibrosis |
| WO2007127428A2 (en) | 2006-04-28 | 2007-11-08 | University Of Florida Research Foundation, Inc. | Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery |
| WO2011075838A1 (en) | 2009-12-21 | 2011-06-30 | Audigen Inc. | Method of treating or preventing hearing loss |
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| EP3492597A3 (en) | 2013-05-21 | 2019-08-28 | University of Florida Research Foundation, Inc. | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
| EP3258955A1 (en) * | 2015-02-20 | 2017-12-27 | Institut Pasteur | Prevention and/or treatment of hearing loss or impairment |
| SG10201913266UA (en) | 2015-12-11 | 2020-02-27 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON |
| KR102606810B1 (ko) * | 2017-05-05 | 2023-11-27 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
| IL325122A (en) * | 2018-02-22 | 2026-02-01 | Akouos Inc | Compositions and methods for treating non-age-related hearing impairment in humans |
| US11660353B2 (en) * | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
-
2020
- 2020-01-20 EP EP23184106.5A patent/EP4295913A3/en active Pending
- 2020-01-20 CA CA3126884A patent/CA3126884A1/en active Pending
- 2020-01-20 ES ES20701951T patent/ES2960880T3/es active Active
- 2020-01-20 BR BR112021013996-6A patent/BR112021013996A2/pt unknown
- 2020-01-20 RS RS20230958A patent/RS64794B1/sr unknown
- 2020-01-20 HR HRP20231296TT patent/HRP20231296T1/hr unknown
- 2020-01-20 WO PCT/EP2020/051283 patent/WO2020148458A1/en not_active Ceased
- 2020-01-20 PT PT207019514T patent/PT3911354T/pt unknown
- 2020-01-20 FI FIEP20701951.4T patent/FI3911354T3/fi active
- 2020-01-20 IL IL284742A patent/IL284742B2/en unknown
- 2020-01-20 EP EP20701951.4A patent/EP3911354B8/en active Active
- 2020-01-20 SM SM20230359T patent/SMT202300359T1/it unknown
- 2020-01-20 PL PL20701951.4T patent/PL3911354T3/pl unknown
- 2020-01-20 CN CN202080022300.3A patent/CN113924109A/zh active Pending
- 2020-01-20 JP JP2021541524A patent/JP7595013B2/ja active Active
- 2020-01-20 LT LTEPPCT/EP2020/051283T patent/LT3911354T/lt unknown
- 2020-01-20 KR KR1020267009428A patent/KR20260046255A/ko active Pending
- 2020-01-20 MX MX2021008622A patent/MX2021008622A/es unknown
- 2020-01-20 SI SI202030290T patent/SI3911354T1/sl unknown
- 2020-01-20 KR KR1020217026056A patent/KR102946735B1/ko active Active
- 2020-01-20 HU HUE20701951A patent/HUE063458T2/hu unknown
- 2020-01-20 AU AU2020208933A patent/AU2020208933B2/en active Active
- 2020-01-20 DK DK20701951.4T patent/DK3911354T5/da active
-
2021
- 2021-01-20 US US17/422,737 patent/US20220125875A1/en active Pending
-
2024
- 2024-11-25 JP JP2024204975A patent/JP2025032155A/ja active Pending
-
2025
- 2025-11-28 AU AU2025271467A patent/AU2025271467A1/en not_active Abandoned
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