JP2022521825A5 - - Google Patents
Info
- Publication number
- JP2022521825A5 JP2022521825A5 JP2021557652A JP2021557652A JP2022521825A5 JP 2022521825 A5 JP2022521825 A5 JP 2022521825A5 JP 2021557652 A JP2021557652 A JP 2021557652A JP 2021557652 A JP2021557652 A JP 2021557652A JP 2022521825 A5 JP2022521825 A5 JP 2022521825A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently
- formula
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962825387P | 2019-03-28 | 2019-03-28 | |
| US62/825,387 | 2019-03-28 | ||
| PCT/US2020/025542 WO2020198711A1 (en) | 2019-03-28 | 2020-03-27 | Androgen receptor modulators and methods for use as proteolysis targeting chimera ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022521825A JP2022521825A (ja) | 2022-04-12 |
| JP2022521825A5 true JP2022521825A5 (cg-RX-API-DMAC10.html) | 2023-04-04 |
Family
ID=72611232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557652A Pending JP2022521825A (ja) | 2019-03-28 | 2020-03-27 | アンドロゲン受容体モジュレーター及びタンパク質分解誘導キメラリガンドとして使用するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230078913A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3946292A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2022521825A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20220004978A (cg-RX-API-DMAC10.html) |
| CN (1) | CN114269331A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2020247255A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3134546A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL286723A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2021011827A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2020198711A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10471023B2 (en) | 2015-03-12 | 2019-11-12 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| US20170298033A1 (en) | 2016-04-15 | 2017-10-19 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| WO2019226991A1 (en) | 2018-05-25 | 2019-11-28 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| US12109179B2 (en) | 2019-03-28 | 2024-10-08 | Essa Pharma Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
| WO2021127443A1 (en) | 2019-12-19 | 2021-06-24 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| EP4135675A4 (en) * | 2020-04-17 | 2024-04-10 | Essa Pharma, Inc. | SOLID FORMS OF AN N-TERMINAL DOMAIN ANDROGEN RECEPTOR INHIBITOR AND USES THEREOF |
| CN115996918A (zh) | 2020-05-09 | 2023-04-21 | 阿尔维纳斯运营股份有限公司 | 制造双官能团化合物的方法、双官能团化合物的超纯形式以及包括所述双官能团化合物的剂型 |
| CN116529248B (zh) * | 2020-11-25 | 2025-10-17 | 西藏海思科制药有限公司 | 一种苯环衍生物及其组合物和药学上的应用 |
| US12152035B2 (en) | 2020-12-30 | 2024-11-26 | Industrial Technology Research Institute | Androgen receptor binding molecule and use thereof |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| JP7744061B2 (ja) * | 2021-07-30 | 2025-09-25 | ヒノバ ファーマシューティカルズ インコーポレイテッド | 二官能性キメラ複素環式化合物及びアンドロゲン受容体分解剤としての使用 |
| WO2023046283A1 (en) * | 2021-09-22 | 2023-03-30 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity |
| WO2023093845A1 (zh) | 2021-11-25 | 2023-06-01 | 江苏恒瑞医药股份有限公司 | 一种用于雄激素受体蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
| CA3240051A1 (en) | 2021-12-30 | 2023-07-06 | Beigene Switzerland Gmbh | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| CN119301111A (zh) | 2022-03-24 | 2025-01-10 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为protac中的降解决定子的2,4-二氧代四氢嘧啶基衍生物 |
| WO2024006207A1 (en) * | 2022-06-26 | 2024-01-04 | Essa Pharma Inc. | An n-terminal domain androgen receptor inhibitor and uses thereof |
| AU2024392985A1 (en) | 2023-12-08 | 2026-06-04 | Arvinas Operations, Inc. | Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy |
| CN119684303A (zh) * | 2023-12-28 | 2025-03-25 | 上海超阳药业有限公司 | 一种双功能可降解雄激素受体的杂环化合物及其应用 |
| WO2025152998A1 (en) * | 2024-01-17 | 2025-07-24 | Foshan Ionova Biotherapeutics Co., Inc. | Compounds for the targeted degradation of androgen receptor and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516835A (zh) * | 2006-07-19 | 2009-08-26 | 俄亥俄州立大学研究基金会 | 选择性雄激素受体调节剂、它们的类似物和衍生物以及它们的用途 |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| FI3988541T3 (fi) * | 2015-01-13 | 2024-09-17 | British Columbia Cancer Agency Branch | Heterosyklisiä yhdisteitä syövän kuvantamiseksi ja hoitamiseksi ja menetelmiä niiden käyttämiseksi |
| US10471023B2 (en) * | 2015-03-12 | 2019-11-12 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| WO2017185031A1 (en) * | 2016-04-22 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use |
| CA3045037A1 (en) * | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| CN110753693A (zh) * | 2016-12-23 | 2020-02-04 | 阿尔维纳斯运营股份有限公司 | Egfr蛋白水解靶向嵌合分子和相关使用方法 |
-
2020
- 2020-03-27 JP JP2021557652A patent/JP2022521825A/ja active Pending
- 2020-03-27 CA CA3134546A patent/CA3134546A1/en active Pending
- 2020-03-27 US US17/599,341 patent/US20230078913A1/en not_active Abandoned
- 2020-03-27 AU AU2020247255A patent/AU2020247255A1/en not_active Abandoned
- 2020-03-27 MX MX2021011827A patent/MX2021011827A/es unknown
- 2020-03-27 KR KR1020217034497A patent/KR20220004978A/ko not_active Ceased
- 2020-03-27 WO PCT/US2020/025542 patent/WO2020198711A1/en not_active Ceased
- 2020-03-27 CN CN202080036492.3A patent/CN114269331A/zh active Pending
- 2020-03-27 EP EP20778151.9A patent/EP3946292A4/en not_active Withdrawn
-
2021
- 2021-09-26 IL IL286723A patent/IL286723A/en unknown
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