JP2022518778A - 嚢胞性線維症の治療のための化合物および方法 - Google Patents

嚢胞性線維症の治療のための化合物および方法 Download PDF

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Publication number
JP2022518778A
JP2022518778A JP2021543157A JP2021543157A JP2022518778A JP 2022518778 A JP2022518778 A JP 2022518778A JP 2021543157 A JP2021543157 A JP 2021543157A JP 2021543157 A JP2021543157 A JP 2021543157A JP 2022518778 A JP2022518778 A JP 2022518778A
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JP2022518778A5 (https=
JPWO2020160010A5 (https=
Inventor
ピー． ザヴィストスキー，マイケル
オールマン，クリストファー
リー，フォン
コロジー，アンドリュー
モーニングスター，マーシャル
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フラットリー ディスカバリー ラブ，エルエルシー
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Publication of JP2022518778A5 publication Critical patent/JP2022518778A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021543157A 2019-01-28 2020-01-28 嚢胞性線維症の治療のための化合物および方法 Pending JP2022518778A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962797743P 2019-01-28 2019-01-28
US62/797,743 2019-01-28
US201962931502P 2019-11-06 2019-11-06
US62/931,502 2019-11-06
PCT/US2020/015441 WO2020160010A1 (en) 2019-01-28 2020-01-28 Compounds and methods for the treatment of cystic fibrosis

Publications (3)

Publication Number Publication Date
JP2022518778A true JP2022518778A (ja) 2022-03-16
JP2022518778A5 JP2022518778A5 (https=) 2023-02-01
JPWO2020160010A5 JPWO2020160010A5 (https=) 2023-02-01

Family

ID=71841934

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021543157A Pending JP2022518778A (ja) 2019-01-28 2020-01-28 嚢胞性線維症の治療のための化合物および方法

Country Status (5)

Country Link
US (1) US20230055237A1 (https=)
EP (1) EP3917516A4 (https=)
JP (1) JP2022518778A (https=)
CN (1) CN113613649A (https=)
WO (1) WO2020160010A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR118050A1 (es) * 2019-02-15 2021-09-15 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x
WO2022032062A1 (en) * 2020-08-06 2022-02-10 Carlex Glass America, Llc Method of attaching a connector to a glazing
EP4029500A1 (en) * 2021-01-15 2022-07-20 Universidad Autónoma de Madrid Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the nrf2-beta-trcp interaction for use in the treatment of nrf2-related diseases
RU2763141C1 (ru) * 2021-06-29 2021-12-27 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Этил (3r*,3a'r*,8a'r*,8b's*)-1',2,3'-триоксо-2',5-дифенил-1-(4-хлорфенил)-1,2,2',3',3a',6',7',8',8a',8b'-декагидро-1'h-спиро[пиррол-3,4'-пирроло[3,4-a]пирролизин]-4-карбоксилат, обладающий противомикробной активностью

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
US20170204110A1 (en) * 2015-12-30 2017-07-20 Flatley Discovery Lab, Llc Compounds and methods for the treatment of cystic fibrosis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010006421A (es) * 2007-12-10 2010-06-25 Novartis Ag Compuestos organicos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
US20170204110A1 (en) * 2015-12-30 2017-07-20 Flatley Discovery Lab, Llc Compounds and methods for the treatment of cystic fibrosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIE, Y. M. ET AL: "Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycload", MOLECULES, vol. 16, no. 10, JPN6023052814, 2011, pages 8745 - 8757, XP055955857, ISSN: 0005373928, DOI: 10.3390/molecules16108745 *

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EP3917516A4 (en) 2022-10-12
US20230055237A1 (en) 2023-02-23
WO2020160010A1 (en) 2020-08-06
CN113613649A (zh) 2021-11-05
EP3917516A1 (en) 2021-12-08

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