JP2022516989A5 - - Google Patents
Info
- Publication number
- JP2022516989A5 JP2022516989A5 JP2021539972A JP2021539972A JP2022516989A5 JP 2022516989 A5 JP2022516989 A5 JP 2022516989A5 JP 2021539972 A JP2021539972 A JP 2021539972A JP 2021539972 A JP2021539972 A JP 2021539972A JP 2022516989 A5 JP2022516989 A5 JP 2022516989A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- composition according
- amount
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962790229P | 2019-01-09 | 2019-01-09 | |
| US62/790,229 | 2019-01-09 | ||
| PCT/US2020/012649 WO2020146441A1 (en) | 2019-01-09 | 2020-01-08 | Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022516989A JP2022516989A (ja) | 2022-03-03 |
| JP2022516989A5 true JP2022516989A5 (https=) | 2023-01-24 |
| JP7489989B2 JP7489989B2 (ja) | 2024-05-24 |
Family
ID=69500831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021539972A Active JP7489989B2 (ja) | 2019-01-09 | 2020-01-08 | (s)-4-(4-(4-(((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-4-イル)オキシ)メチル)ベンジル)ピペラジン-1-イル)-3-フルオロベンゾニトリルを含む医薬組成物及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11779580B2 (https=) |
| EP (1) | EP3908254A1 (https=) |
| JP (1) | JP7489989B2 (https=) |
| KR (1) | KR20210113290A (https=) |
| CN (2) | CN113597301A (https=) |
| AU (1) | AU2020206692B2 (https=) |
| CA (1) | CA3126067A1 (https=) |
| EA (1) | EA202191904A1 (https=) |
| IL (1) | IL284665A (https=) |
| MX (1) | MX2021008321A (https=) |
| SG (1) | SG11202107438WA (https=) |
| WO (1) | WO2020146441A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK4178548T3 (da) | 2020-07-07 | 2024-08-19 | Celgene Corp | Farmaceutiske sammensætninger omfattende (S)-4-(4-(4-(((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL)BENZYL)PIPERAZIN-1-YL)-3-FLUORBENZONITRIL |
| KR20240013793A (ko) | 2021-05-27 | 2024-01-30 | 셀진 코포레이션 | 조합 요법을 사용하는 다발성 골수종의 치료 방법 |
| WO2025240252A1 (en) * | 2024-05-13 | 2025-11-20 | Beta Pharma, Inc. | Estrogen receptor degraders as treatments for breast cancer |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US5948893A (en) | 1996-01-17 | 1999-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| TW200418836A (en) * | 2002-09-10 | 2004-10-01 | Pharmacia Italia Spa | Formulations comprising an indolinone compound |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| BR122017025062B8 (pt) | 2007-06-18 | 2021-07-27 | Merck Sharp & Dohme | anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2011082400A2 (en) | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| PL3202460T3 (pl) * | 2010-02-11 | 2019-12-31 | Celgene Corporation | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| EP2604248B1 (en) * | 2011-12-13 | 2017-10-25 | Unilever PLC | Oil-in-water cosmetic composition |
| WO2014191806A2 (en) * | 2013-05-02 | 2014-12-04 | Effrx Pharmaceuticals Sa | Effervescent formulations that deliver particles which float in the stomach |
| UA117141C2 (uk) * | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
| EP4467143B1 (en) * | 2017-07-10 | 2026-03-11 | Celgene Corporation | Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile |
| KR102718800B1 (ko) * | 2018-05-23 | 2024-10-18 | 셀진 코포레이션 | 다발성 골수종의 치료 및 4-(4-(4-(((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조니트릴에 대한 바이오마커의 용도 |
| PL3796912T3 (pl) | 2018-05-23 | 2023-09-11 | Celgene Corporation | Związki przeciwproliferacyjne i przeciwciało bispecyficzne przeciwko bcma i cd3 do zastosowania kombinowanego |
| FI3908281T3 (fi) | 2019-01-09 | 2024-10-01 | Celgene Corp | Antiproliferatiivisia yhdisteitä ja toisia aktiivisia aineita käytettäväksi multippelin myelooman hoidossa |
| SG11202107439XA (en) | 2019-01-09 | 2021-08-30 | Celgene Corp | Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same |
-
2020
- 2020-01-08 WO PCT/US2020/012649 patent/WO2020146441A1/en not_active Ceased
- 2020-01-08 AU AU2020206692A patent/AU2020206692B2/en active Active
- 2020-01-08 JP JP2021539972A patent/JP7489989B2/ja active Active
- 2020-01-08 SG SG11202107438WA patent/SG11202107438WA/en unknown
- 2020-01-08 CA CA3126067A patent/CA3126067A1/en active Pending
- 2020-01-08 US US16/737,721 patent/US11779580B2/en active Active
- 2020-01-08 EP EP20704118.7A patent/EP3908254A1/en active Pending
- 2020-01-08 MX MX2021008321A patent/MX2021008321A/es unknown
- 2020-01-08 KR KR1020217024896A patent/KR20210113290A/ko active Pending
- 2020-01-08 CN CN202080012815.5A patent/CN113597301A/zh active Pending
- 2020-01-08 EA EA202191904A patent/EA202191904A1/ru unknown
- 2020-01-08 CN CN202210010518.8A patent/CN114409630B/zh active Active
-
2021
- 2021-07-06 IL IL284665A patent/IL284665A/en unknown
-
2023
- 2023-08-30 US US18/240,076 patent/US12064427B2/en active Active
-
2024
- 2024-07-09 US US18/767,295 patent/US20240358697A1/en active Pending
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