JP2022516710A - Car t細胞の方法及び構築物 - Google Patents
Car t細胞の方法及び構築物 Download PDFInfo
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- JP2022516710A JP2022516710A JP2021537208A JP2021537208A JP2022516710A JP 2022516710 A JP2022516710 A JP 2022516710A JP 2021537208 A JP2021537208 A JP 2021537208A JP 2021537208 A JP2021537208 A JP 2021537208A JP 2022516710 A JP2022516710 A JP 2022516710A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001112—CD19 or B4
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70517—CD8
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10071—Demonstrated in vivo effect
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13061—Methods of inactivation or attenuation
- C12N2740/13062—Methods of inactivation or attenuation by genetic engineering
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962788894P | 2019-01-06 | 2019-01-06 | |
| US62/788,894 | 2019-01-06 | ||
| PCT/US2020/012417 WO2020142780A1 (en) | 2019-01-06 | 2020-01-06 | Car t cell methods and constructs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022516710A true JP2022516710A (ja) | 2022-03-02 |
| JPWO2020142780A5 JPWO2020142780A5 (https=) | 2023-01-19 |
| JP2022516710A5 JP2022516710A5 (https=) | 2023-01-19 |
Family
ID=71406633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537208A Pending JP2022516710A (ja) | 2019-01-06 | 2020-01-06 | Car t細胞の方法及び構築物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220090132A1 (https=) |
| EP (1) | EP3906311A4 (https=) |
| JP (1) | JP2022516710A (https=) |
| KR (1) | KR20210137427A (https=) |
| CN (1) | CN113382741A (https=) |
| AU (1) | AU2020205000A1 (https=) |
| BR (1) | BR112021013180A2 (https=) |
| CA (1) | CA3125201A1 (https=) |
| IL (1) | IL284461A (https=) |
| PH (1) | PH12021551619A1 (https=) |
| SG (1) | SG11202107246TA (https=) |
| WO (1) | WO2020142780A1 (https=) |
| ZA (1) | ZA202103899B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12419913B2 (en) | 2019-02-08 | 2025-09-23 | Dna Twopointo, Inc. | Modification of CAR-T cells |
| WO2025084880A1 (ko) * | 2023-10-20 | 2025-04-24 | 주식회사 이온셀 | Ct83 항원에 결합하는 car-t 세포 및 이의 용도 |
| CN117567650B (zh) * | 2024-01-15 | 2024-04-02 | 中国人民解放军东部战区总医院 | 共表达细胞间黏附分子icam2的car-t细胞及其制备方法与应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017511128A (ja) * | 2014-03-26 | 2017-04-20 | トカジェン インコーポレーテッド | 免疫刺激活性を有するレトロウイルスベクター |
| JP2018518152A (ja) * | 2015-03-27 | 2018-07-12 | ユニバーシティ オブ サザン カリフォルニア | 充実性腫瘍を処置するためのlhrに指向されたcar t細胞治療 |
| JP2018522833A (ja) * | 2015-06-12 | 2018-08-16 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998000541A2 (en) * | 1996-07-03 | 1998-01-08 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of human disease |
| CA2371216A1 (en) * | 1999-04-23 | 2000-11-02 | Centre For Translational Research In Cancer | Pseudotyped retroviral vector for gene therapy of cancer |
| AU2001265187A1 (en) * | 2000-05-30 | 2001-12-11 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| GB201322798D0 (en) * | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
| EP3286225B1 (en) * | 2015-04-23 | 2020-07-01 | Baylor College of Medicine | Cd5 chimeric antigen receptor for adoptive t cell therapy |
| MA46236A (fr) * | 2016-09-14 | 2019-07-24 | Janssen Biotech Inc | Récepteurs antigéniques chimériques comprenant des domaines de la fibronectine de type iii spécifiques du bcma, et utilisations correspondantes |
| CA3068634A1 (en) * | 2017-06-30 | 2019-01-03 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
-
2020
- 2020-01-06 WO PCT/US2020/012417 patent/WO2020142780A1/en not_active Ceased
- 2020-01-06 US US17/419,239 patent/US20220090132A1/en not_active Abandoned
- 2020-01-06 JP JP2021537208A patent/JP2022516710A/ja active Pending
- 2020-01-06 AU AU2020205000A patent/AU2020205000A1/en not_active Abandoned
- 2020-01-06 CA CA3125201A patent/CA3125201A1/en active Pending
- 2020-01-06 CN CN202080007932.2A patent/CN113382741A/zh active Pending
- 2020-01-06 SG SG11202107246TA patent/SG11202107246TA/en unknown
- 2020-01-06 BR BR112021013180A patent/BR112021013180A2/pt not_active IP Right Cessation
- 2020-01-06 KR KR1020217020488A patent/KR20210137427A/ko not_active Ceased
- 2020-01-06 PH PH1/2021/551619A patent/PH12021551619A1/en unknown
- 2020-01-06 EP EP20736060.3A patent/EP3906311A4/en active Pending
-
2021
- 2021-06-07 ZA ZA2021/03899A patent/ZA202103899B/en unknown
- 2021-06-29 IL IL284461A patent/IL284461A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017511128A (ja) * | 2014-03-26 | 2017-04-20 | トカジェン インコーポレーテッド | 免疫刺激活性を有するレトロウイルスベクター |
| JP2018518152A (ja) * | 2015-03-27 | 2018-07-12 | ユニバーシティ オブ サザン カリフォルニア | 充実性腫瘍を処置するためのlhrに指向されたcar t細胞治療 |
| JP2018522833A (ja) * | 2015-06-12 | 2018-08-16 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療 |
Non-Patent Citations (3)
| Title |
|---|
| EMBO MOLECULAR MEDICINE, vol. 10, e9158, JPN6023053961, 2018, pages 1 - 11, ISSN: 0005236035 * |
| MOLECULAR THERAPY, vol. 26, no. 1, JPN6023053960, 2018, pages 6 - 7, ISSN: 0005410273 * |
| MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT, vol. 4, JPN6023053959, 2017, pages 92 - 101, ISSN: 0005410272 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220090132A1 (en) | 2022-03-24 |
| AU2020205000A1 (en) | 2021-06-17 |
| ZA202103899B (en) | 2022-09-28 |
| KR20210137427A (ko) | 2021-11-17 |
| BR112021013180A2 (pt) | 2022-04-12 |
| SG11202107246TA (en) | 2021-07-29 |
| IL284461A (en) | 2021-08-31 |
| PH12021551619A1 (en) | 2022-05-23 |
| WO2020142780A1 (en) | 2020-07-09 |
| CA3125201A1 (en) | 2020-07-09 |
| EP3906311A1 (en) | 2021-11-10 |
| CN113382741A (zh) | 2021-09-10 |
| EP3906311A4 (en) | 2022-09-28 |
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