CN113382741A - Car t细胞方法和构建体 - Google Patents

Car t细胞方法和构建体 Download PDF

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CN113382741A
CN113382741A CN202080007932.2A CN202080007932A CN113382741A CN 113382741 A CN113382741 A CN 113382741A CN 202080007932 A CN202080007932 A CN 202080007932A CN 113382741 A CN113382741 A CN 113382741A
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val
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receptor
glu
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D·J·朱莉
J·M·罗宾斯
A·H·林
D·G·奥斯特塔格
C·宾利
S·维奥
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Ebintos Biology
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CN202080007932.2A 2019-01-06 2020-01-06 Car t细胞方法和构建体 Pending CN113382741A (zh)

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US201962788894P 2019-01-06 2019-01-06
US62/788894 2019-01-06
PCT/US2020/012417 WO2020142780A1 (en) 2019-01-06 2020-01-06 Car t cell methods and constructs

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US (1) US20220090132A1 (https=)
EP (1) EP3906311A4 (https=)
JP (1) JP2022516710A (https=)
KR (1) KR20210137427A (https=)
CN (1) CN113382741A (https=)
AU (1) AU2020205000A1 (https=)
BR (1) BR112021013180A2 (https=)
CA (1) CA3125201A1 (https=)
IL (1) IL284461A (https=)
PH (1) PH12021551619A1 (https=)
SG (1) SG11202107246TA (https=)
WO (1) WO2020142780A1 (https=)
ZA (1) ZA202103899B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117567650A (zh) * 2024-01-15 2024-02-20 中国人民解放军东部战区总医院 共表达细胞间黏附分子icam2的car-t细胞及其制备方法与应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells
WO2025084880A1 (ko) * 2023-10-20 2025-04-24 주식회사 이온셀 Ct83 항원에 결합하는 car-t 세포 및 이의 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000541A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of human disease
WO2000065034A2 (en) * 1999-04-23 2000-11-02 Centre For Translational Research In Cancer Pseudotyped retroviral vector for gene therapy of cancer
WO2012079000A1 (en) * 2010-12-09 2012-06-14 The Trustees Of The University Of Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US20160333373A1 (en) * 2013-12-20 2016-11-17 Oxford Biomedica (Uk) Limited Viral Vector Production System
US20170175137A1 (en) * 2014-03-26 2017-06-22 Tocagen Inc. Retroviral vector having immune-stimulating activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001265187A1 (en) * 2000-05-30 2001-12-11 Baylor College Of Medicine Chimeric viral vectors for gene therapy
US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
AU2016243124A1 (en) * 2015-03-27 2017-11-02 University Of Southern California CAR T-cell therapy directed to LHR for the treatment of solid tumors
EP3286225B1 (en) * 2015-04-23 2020-07-01 Baylor College of Medicine Cd5 chimeric antigen receptor for adoptive t cell therapy
CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
MA46236A (fr) * 2016-09-14 2019-07-24 Janssen Biotech Inc Récepteurs antigéniques chimériques comprenant des domaines de la fibronectine de type iii spécifiques du bcma, et utilisations correspondantes
CA3068634A1 (en) * 2017-06-30 2019-01-03 Memorial Sloan Kettering Cancer Center Compositions and methods for adoptive cell therapy for cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000541A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of human disease
WO2000065034A2 (en) * 1999-04-23 2000-11-02 Centre For Translational Research In Cancer Pseudotyped retroviral vector for gene therapy of cancer
WO2012079000A1 (en) * 2010-12-09 2012-06-14 The Trustees Of The University Of Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US20160333373A1 (en) * 2013-12-20 2016-11-17 Oxford Biomedica (Uk) Limited Viral Vector Production System
US20170175137A1 (en) * 2014-03-26 2017-06-22 Tocagen Inc. Retroviral vector having immune-stimulating activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRUCE L LECINE等: "Global Manufacturing of CAR T Cell Therapy", 《MOL THER METHODS CLIN DEV.》, vol. 4, 31 December 2016 (2016-12-31), pages 92 - 101, XP055510414, DOI: 10.1016/j.omtm.2016.12.006 *
PHILIP L. SHERIDAN等: "Generation of Retroviral Packaging and Producer Cell Lines for Large-Scale Vector Production and Clinical Application:Improved Safety and High Titer", 《MOLECULAR THERAPY》, vol. 2, no. 3, 27 March 2000 (2000-03-27), pages 262 - 275, XP055547590, DOI: 10.1006/mthe.2000.0123 *
伍新尧: "《分子遗传学与基因工程》", 31 December 1997, 郑州:河南医科大学出版社, pages: 246 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117567650A (zh) * 2024-01-15 2024-02-20 中国人民解放军东部战区总医院 共表达细胞间黏附分子icam2的car-t细胞及其制备方法与应用
CN117567650B (zh) * 2024-01-15 2024-04-02 中国人民解放军东部战区总医院 共表达细胞间黏附分子icam2的car-t细胞及其制备方法与应用

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US20220090132A1 (en) 2022-03-24
AU2020205000A1 (en) 2021-06-17
JP2022516710A (ja) 2022-03-02
ZA202103899B (en) 2022-09-28
KR20210137427A (ko) 2021-11-17
BR112021013180A2 (pt) 2022-04-12
SG11202107246TA (en) 2021-07-29
IL284461A (en) 2021-08-31
PH12021551619A1 (en) 2022-05-23
WO2020142780A1 (en) 2020-07-09
CA3125201A1 (en) 2020-07-09
EP3906311A1 (en) 2021-11-10
EP3906311A4 (en) 2022-09-28

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