JP2022515128A5 - - Google Patents

Info

Publication number
JP2022515128A5
JP2022515128A5 JP2021535545A JP2021535545A JP2022515128A5 JP 2022515128 A5 JP2022515128 A5 JP 2022515128A5 JP 2021535545 A JP2021535545 A JP 2021535545A JP 2021535545 A JP2021535545 A JP 2021535545A JP 2022515128 A5 JP2022515128 A5 JP 2022515128A5
Authority
JP
Japan
Prior art keywords
exon
mutation
her2
poziotinib
tki
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021535545A
Other languages
English (en)
Japanese (ja)
Other versions
JP7564806B2 (ja
JP2022515128A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/068153 external-priority patent/WO2020132633A1/en
Publication of JP2022515128A publication Critical patent/JP2022515128A/ja
Publication of JP2022515128A5 publication Critical patent/JP2022515128A5/ja
Application granted granted Critical
Publication of JP7564806B2 publication Critical patent/JP7564806B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021535545A 2018-12-21 2019-12-20 がんの処置のための併用療法 Active JP7564806B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862784084P 2018-12-21 2018-12-21
US62/784,084 2018-12-21
PCT/US2019/068153 WO2020132633A1 (en) 2018-12-21 2019-12-20 Combination therapy for the treatment of cancer

Publications (3)

Publication Number Publication Date
JP2022515128A JP2022515128A (ja) 2022-02-17
JP2022515128A5 true JP2022515128A5 (https=) 2022-12-27
JP7564806B2 JP7564806B2 (ja) 2024-10-09

Family

ID=71102908

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535545A Active JP7564806B2 (ja) 2018-12-21 2019-12-20 がんの処置のための併用療法

Country Status (14)

Country Link
US (1) US20220041751A1 (https=)
EP (1) EP3897650A4 (https=)
JP (1) JP7564806B2 (https=)
KR (1) KR20210107023A (https=)
CN (1) CN113271948B (https=)
AU (1) AU2019406210A1 (https=)
BR (1) BR112021011493A2 (https=)
CA (1) CA3121807A1 (https=)
IL (1) IL284162A (https=)
MA (1) MA54559A (https=)
MX (1) MX2021007554A (https=)
PH (1) PH12021551276A1 (https=)
SG (1) SG11202105736QA (https=)
WO (1) WO2020132633A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019243738B2 (en) * 2018-03-27 2024-05-30 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 19 mutations
MX2021011925A (es) * 2019-03-29 2021-11-03 Univ Texas Compuestos con actividad antitumoral contra celulas cancerigenas que portan inserciones del exon 21 del receptor 2 del factor de crecimiento epidermico humano.
TW202330040A (zh) * 2021-10-14 2023-08-01 大陸商江蘇恆瑞醫藥股份有限公司 抗her2抗體藥物偶聯物和酪胺酸激酶抑制劑聯合在製備治療腫瘤的藥物中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102771603B1 (ko) * 2016-11-17 2025-02-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Egfr 또는 her2 엑손 20 돌연변이를 갖는 암 세포에 대한 항종양 활성을 갖는 화합물
AU2019243738B2 (en) * 2018-03-27 2024-05-30 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 19 mutations
KR20210025064A (ko) 2018-06-25 2021-03-08 스펙트럼 파마슈티컬즈 인크 항-her1, her2 또는 her4 항체와 포지오티닙의 조합물 및 이의 사용 방법

Similar Documents

Publication Publication Date Title
JP7265985B2 (ja) Egfrまたはher2のエクソン20変異を有するがん細胞に対する抗腫瘍活性を有する化合物
Prelaj et al. Poziotinib for EGFR and HER2 exon 20 insertion mutation in advanced NSCLC: results from the expanded access program
Kim et al. Phase 1 studies of poziotinib, an irreversible pan-HER tyrosine kinase inhibitor in patients with advanced solid tumors
JP2022527788A5 (https=)
Martinez-Useros et al. The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas
JP2022529016A5 (https=)
JP2022529945A5 (https=)
JP2022515128A5 (https=)
TW202529804A (zh) 用於癌症治療的組合療法
CN111867586A (zh) 用于治疗具有egfr激活突变的癌症的方法
WO2020030977A2 (en) Methods and compositions for inhibition of egf/egfr pathway in cobination with anaplastic lymphoma kinase inhibitors
AU2020391222A1 (en) Combination therapy involving diaryl macrocyclic compounds
JP2022527499A5 (https=)
Kim et al. A phase II trial of nintedanib in patients with metastatic or recurrent head and neck squamous cell carcinoma: in-depth analysis of nintedanib arm from the KCSG HN 15-16 TRIUMPH trial
JP2021519306A5 (https=)
Xie et al. Amivantamab: a monoclonal EGFR-MET bispecific antibody for EGFR exon 20 insertion in non-small cell lung cancer
US20210260064A1 (en) Poziotinib combinations with an anti-her1, her2 or her4 antibody and methods of use thereof
RU2020134932A (ru) Соединения с противоопухолевой активностью против раковых клеток, несущих мутации в экзоне 19her2
CN107949401A (zh) 联合施用酪氨酸激酶抑制剂来抑制表皮生长因子/表皮生长因子受体途径的方法及组合物
CN115698338A (zh) 用妥卡替尼治疗her2突变型癌症的方法
Grellety et al. A clinical case of invasive lobular breast carcinoma with ERBB2 and CDH1 mutations presenting a dramatic response to anti-HER2-directed therapy
JP7334194B2 (ja) Tp53突然変異状態及び高頻度突然変異状態に基づくがん治療法
CN119604291A (zh) Blu-945联合奥斯替尼治疗非小细胞肺癌
RU2021121207A (ru) Комбинированная терапия для лечения рака
JP2019123671A (ja) 前立腺がんの予防又は治療剤