JP2022512676A - 大環状インフルエンザエンドヌクレアーゼ阻害剤 - Google Patents
大環状インフルエンザエンドヌクレアーゼ阻害剤 Download PDFInfo
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- JP2022512676A JP2022512676A JP2021519876A JP2021519876A JP2022512676A JP 2022512676 A JP2022512676 A JP 2022512676A JP 2021519876 A JP2021519876 A JP 2021519876A JP 2021519876 A JP2021519876 A JP 2021519876A JP 2022512676 A JP2022512676 A JP 2022512676A
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- dione
- phenyl
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- SJNHARBYICTNAF-OAQYLSRUSA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c(cccc3)c3OCCOCCN1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c(cccc3)c3OCCOCCN1C2=O SJNHARBYICTNAF-OAQYLSRUSA-N 0.000 description 1
- TWLYQZUCRVMHIK-BBIZLLLXSA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c(cccc3C(F)(F)F)c3OC/C=C\CN1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c(cccc3C(F)(F)F)c3OC/C=C\CN1C2=O TWLYQZUCRVMHIK-BBIZLLLXSA-N 0.000 description 1
- COACKJLPCHZWGL-HXUWFJFHSA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c3cccc(F)c3OCCCCN1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c3cccc(F)c3OCCCCN1C2=O COACKJLPCHZWGL-HXUWFJFHSA-N 0.000 description 1
- BNJLOWNQDDRSII-RGPRSXKESA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c3ccccc3OC/C=C/C3(CCC3)N1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3)c3ccccc3OC/C=C/C3(CCC3)N1C2=O BNJLOWNQDDRSII-RGPRSXKESA-N 0.000 description 1
- MCZPJPITOMHTBN-HZQHCPKGSA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3C(F)F)c(ccc(F)c3F)c3OC/C=C\CN1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3C(F)F)c(ccc(F)c3F)c3OC/C=C\CN1C2=O MCZPJPITOMHTBN-HZQHCPKGSA-N 0.000 description 1
- UPPMHRJZYQQKQY-OSFWOZTASA-N OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3C3CC3)c(cccc3F)c3OC/C=C/CN1C2=O Chemical compound OC(C(C=C1)=O)=C2N1N(C1)[C@H](c3ccccc3C3CC3)c(cccc3F)c3OC/C=C/CN1C2=O UPPMHRJZYQQKQY-OSFWOZTASA-N 0.000 description 1
- YAEVHZGBIZRKBF-OVZCHOQHSA-N OC(C1N(C=C2)N(C3)[C@@H](c4ccccc4SC4)c5c4cccc5OC(C4)CC4CCN3C1=O)C2=O Chemical compound OC(C1N(C=C2)N(C3)[C@@H](c4ccccc4SC4)c5c4cccc5OC(C4)CC4CCN3C1=O)C2=O YAEVHZGBIZRKBF-OVZCHOQHSA-N 0.000 description 1
- YAEVHZGBIZRKBF-BDZTZWKLSA-N OC(C1N(C=C2)N(C3)[C@H](c(cccc4)c4SCc4ccc5)c4c5OC(C4)CC4CCN3C1=O)C2=O Chemical compound OC(C1N(C=C2)N(C3)[C@H](c(cccc4)c4SCc4ccc5)c4c5OC(C4)CC4CCN3C1=O)C2=O YAEVHZGBIZRKBF-BDZTZWKLSA-N 0.000 description 1
- GEYVXKRQBNSHDQ-DEOSSOPVSA-N OC(CC=C1)=C2N1N(C1)[C@@H](c3ccccc3SC3)c4c3cccc4OCCCCCN1C2=O Chemical compound OC(CC=C1)=C2N1N(C1)[C@@H](c3ccccc3SC3)c4c3cccc4OCCCCCN1C2=O GEYVXKRQBNSHDQ-DEOSSOPVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862744060P | 2018-10-10 | 2018-10-10 | |
| US62/744,060 | 2018-10-10 | ||
| PCT/IB2019/058591 WO2020075080A1 (en) | 2018-10-10 | 2019-10-09 | Macrocyclic flu endonuclease inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512676A true JP2022512676A (ja) | 2022-02-07 |
| JP2022512676A5 JP2022512676A5 (https=) | 2022-10-17 |
| JPWO2020075080A5 JPWO2020075080A5 (https=) | 2022-10-17 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021519876A Withdrawn JP2022512676A (ja) | 2018-10-10 | 2019-10-09 | 大環状インフルエンザエンドヌクレアーゼ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11312727B1 (https=) |
| EP (1) | EP3864020A1 (https=) |
| JP (1) | JP2022512676A (https=) |
| KR (1) | KR20210074329A (https=) |
| CN (1) | CN113195502A (https=) |
| AU (1) | AU2019359539A1 (https=) |
| CA (1) | CA3115792A1 (https=) |
| MX (1) | MX2021004182A (https=) |
| TW (1) | TW202035424A (https=) |
| WO (1) | WO2020075080A1 (https=) |
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| WO2020197991A1 (en) | 2019-03-22 | 2020-10-01 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| WO2021191872A1 (en) * | 2020-03-26 | 2021-09-30 | Janssen Biopharma, Inc. | Heteroaryl-substituted macrocyclic flu endonuclease inhibitors |
| CN113444010B (zh) * | 2020-03-28 | 2023-09-05 | 南京正大天晴制药有限公司 | 一种沙芬酰胺有关物质的制备方法 |
| US12516070B2 (en) | 2020-05-21 | 2026-01-06 | Cisen Pharmaceutical Co., Ltd | Fused ring derivatives and use thereof in pharmacy |
| TW202146413A (zh) * | 2020-06-12 | 2021-12-16 | 大陸商上海翰森生物醫藥科技有限公司 | 含吡啶酮稠環類衍生物抑制劑、其製備方法和應用 |
| CA3192145A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| WO2022105669A1 (zh) * | 2020-11-17 | 2022-05-27 | 南京明德新药研发有限公司 | 含Se大环类化合物 |
| FI4196479T3 (fi) * | 2021-01-19 | 2024-01-17 | Gilead Sciences Inc | Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä |
| EP4384178A4 (en) * | 2021-08-11 | 2025-07-02 | Merck Sharp & Dohme Llc | POLYCYCLIC CAP-DEPENDENT ENDONUCLEASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLUENZA |
| CN118317964A (zh) * | 2021-11-17 | 2024-07-09 | 辰欣药业股份有限公司 | 一种稠环衍生物的晶型及其制备方法 |
| WO2025015300A2 (en) * | 2023-07-12 | 2025-01-16 | Apac Pharma, Llc | Hepoxilin analogs, methods, uses, and processes for preparation thereof |
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| LT2444400T (lt) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
| MX2013003139A (es) * | 2010-09-24 | 2013-06-18 | Shionogi & Co | Profarmaco de derivado de carbamoilpiridona policiclica substituida. |
| ES2724581T3 (es) * | 2013-09-12 | 2019-09-12 | Janssen Biopharma Inc | Compuestos de piridazinona y usos de los mismos |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
-
2019
- 2019-10-09 MX MX2021004182A patent/MX2021004182A/es unknown
- 2019-10-09 WO PCT/IB2019/058591 patent/WO2020075080A1/en not_active Ceased
- 2019-10-09 AU AU2019359539A patent/AU2019359539A1/en not_active Abandoned
- 2019-10-09 CA CA3115792A patent/CA3115792A1/en active Pending
- 2019-10-09 TW TW108136776A patent/TW202035424A/zh unknown
- 2019-10-09 EP EP19787467.0A patent/EP3864020A1/en not_active Withdrawn
- 2019-10-09 US US17/284,162 patent/US11312727B1/en active Active
- 2019-10-09 CN CN201980082149.XA patent/CN113195502A/zh active Pending
- 2019-10-09 KR KR1020217013939A patent/KR20210074329A/ko not_active Ceased
- 2019-10-09 JP JP2021519876A patent/JP2022512676A/ja not_active Withdrawn
-
2022
- 2022-03-15 US US17/694,757 patent/US20230002409A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA3115792A1 (en) | 2020-04-16 |
| US20230002409A1 (en) | 2023-01-05 |
| KR20210074329A (ko) | 2021-06-21 |
| MX2021004182A (es) | 2021-09-08 |
| CN113195502A (zh) | 2021-07-30 |
| EP3864020A1 (en) | 2021-08-18 |
| WO2020075080A1 (en) | 2020-04-16 |
| AU2019359539A1 (en) | 2021-04-29 |
| US11312727B1 (en) | 2022-04-26 |
| TW202035424A (zh) | 2020-10-01 |
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